felodipine has been researched along with Muscle Contraction in 36 studies
Felodipine: A dihydropyridine calcium antagonist with positive inotropic effects. It lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels.
felodipine : The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The influence of calcium channel antagonists, felodipine and cadmium, as well as pertussis toxin on noradrenaline-induced contractions in pulmonary artery rings from rats with pulmonary hypertension induced by monocrotaline (MCT) were examined." | 3.69 | Effects of calcium channel antagonists and pertussis toxin on noradrenaline-induced contractions in pulmonary artery from pulmonary hypertensive rats. ( Lin, BP; MacNicol, BJ; Tabrizchi, R, 1995) |
| "Nifedipine has been used in the treatment of sphincter of Oddi dyskinesia, a biliary disease characterized by upper abdominal pains and increased pressure in the sphincter." | 1.33 | Calcium channel antagonists and inhibition of human sphincter of Oddi contractions. ( Arvola, P; Nordback, I; Sand, J, 2005) |
| "Felodipine is a new generation 1,4 dihydropyridine (1,4 DHP) Ca(2+)-entrance blocker with marked vascular selectivity." | 1.29 | Felodipine and vasomotion physiology. ( Karatzas, D; Kokkas, B; Kotoula, M; Kouvelas, D; Kouyoumtzis, A; Papadopoulos, C; Paradelis, A, 1993) |
| "Felodipine treatment produced a significant decrease in blood pressure in SHRSP (control SHRSP: 240 +/- 7 mmHg, n = 6; felodipine-treated SHRSP: 164 +/- 8 mmHg, n = 5, P less than 0." | 1.28 | Effect of felodipine on blood pressure and vascular reactivity in stroke-prone spontaneously hypertensive rats. ( Bruner, CA; Webb, RC, 1989) |
| "Felodipine is a potent, but relatively slow, relaxation agent in rat caudal artery, decreasing 30 mM K+ contractions by 39% at a concentration of 1 nM and 88% at 10 nM." | 1.27 | Felodipine actions on vascular muscle Ca2+ channels. ( Hermsmeyer, K; Rusch, NJ, 1987) |
| "Felodipine is a dihydropyridine calcium antagonist that exerts a markedly selective inhibition of the smooth muscle of arterial resistance vessels." | 1.27 | Felodipine sensitivity in vivo and in vitro of activation pathways in vascular smooth muscles. ( Johansson, B; Ljung, B; Nordlander, M, 1987) |
| " In addition, verapamil shifted the dose-response curves for both 5-HT and PE to the right in parallel, indicative of competitive antagonism." | 1.27 | Studies on the site of the interaction between alpha 1-adrenoceptors and 5-HT2 receptors in rat tail arteries. ( Marwood, JF, 1988) |
| "Lanthanum (2 mM) was considerably more effective to prevent contractions than the Ca antagonists." | 1.27 | Low potency of Ca antagonists in smooth muscle from different levels of the respiratory tract. ( Bengtsson, B; Khan, AR; Weiber, R, 1987) |
| "Felodipine was the first compound tested to display a 100-fold vascular selectivity in this test system." | 1.27 | Vascular selectivity of felodipine. ( Ljung, B, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (44.44) | 18.7374 |
| 1990's | 19 (52.78) | 18.2507 |
| 2000's | 1 (2.78) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alker, D | 1 |
| Campbell, SF | 1 |
| Cross, PE | 1 |
| Burges, RA | 1 |
| Carter, AJ | 1 |
| Gardiner, DG | 1 |
| Sand, J | 1 |
| Arvola, P | 1 |
| Nordback, I | 1 |
| Mulvany, MJ | 2 |
| Aalkjaer, C | 1 |
| Petersen, TT | 1 |
| Bostróm, SL | 2 |
| Ljung, B | 5 |
| Mårdh, S | 1 |
| Forsen, S | 1 |
| Thulin, E | 1 |
| Tabrizchi, R | 4 |
| MacNicol, BJ | 1 |
| Lin, BP | 1 |
| Hagiwara, S | 1 |
| Mitsui, M | 1 |
| Karaki, H | 1 |
| Bülow, A | 2 |
| Johansson, B | 3 |
| Yao, MH | 1 |
| Dai, ZX | 1 |
| Xu, DZ | 1 |
| Yang, ZC | 2 |
| Kokkas, B | 1 |
| Papadopoulos, C | 1 |
| Kotoula, M | 1 |
| Kouyoumtzis, A | 1 |
| Kouvelas, D | 1 |
| Karatzas, D | 1 |
| Paradelis, A | 1 |
| Lum Min, SA | 1 |
| Okoro, EO | 1 |
| Marwood, JF | 2 |
| Mervaala, EM | 1 |
| Teräväinen, TL | 1 |
| Malmberg, L | 1 |
| Laakso, J | 1 |
| Pörsti, I | 1 |
| Vapaatalo, H | 1 |
| Karppanen, H | 1 |
| Min, SA | 1 |
| Stapleton, MP | 1 |
| Oba, T | 2 |
| Yamaguchi, M | 2 |
| Wang, S | 1 |
| Johnson, JD | 1 |
| Lu, A | 1 |
| Yamano, S | 1 |
| Sako, T | 1 |
| Kuroda, K | 1 |
| Fukuda, Y | 1 |
| Nakao, K | 1 |
| Inukai, T | 1 |
| Wanstall, JC | 1 |
| O'Donnell, SR | 1 |
| Kay, CS | 1 |
| Dong, H | 1 |
| Lu, YQ | 1 |
| Yang, QQ | 1 |
| Wang, Q | 1 |
| Lydrup, ML | 1 |
| Hellstrand, P | 1 |
| Wiklund, NP | 1 |
| Ohlén, A | 1 |
| Wiklund, CU | 1 |
| Hedqvist, P | 1 |
| Gustafsson, LE | 1 |
| Nyborg, NC | 1 |
| Byg-Hansen, J | 1 |
| Nordlander, M | 2 |
| Thalén, P | 1 |
| Kjellstedt, A | 2 |
| Orebäck, B | 1 |
| Hermsmeyer, K | 1 |
| Rusch, NJ | 1 |
| Berntsson, P | 1 |
| Johansson, E | 1 |
| Westerlund, C | 2 |
| Nilsson, A | 1 |
| Simonsson, R | 1 |
| Boström, S | 1 |
| Bruner, CA | 1 |
| Webb, RC | 1 |
| Sutter, MC | 1 |
| May, PB | 1 |
| Lim, SL | 1 |
| Arner, A | 1 |
| Bengtsson, B | 1 |
| Khan, AR | 1 |
| Weiber, R | 1 |
36 other studies available for felodipine and Muscle Contraction
| Article | Year |
|---|---|
Long-acting dihydropyridine calcium antagonists. 4. Synthesis and structure-activity relationships for a series of basic and nonbasic derivatives of 2-[(2-aminoethoxy)methyl]-1,4-dihydropyridine calcium antagonists.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Chemical Phenomena; Chemistry; Dihydropyridines | 1990 |
Calcium channel antagonists and inhibition of human sphincter of Oddi contractions.
Topics: Calcium Channel Blockers; Felodipine; Humans; Muscle Contraction; Muscle, Smooth; Nifedipine; Sphinc | 2005 |
Intracellular sodium, membrane potential, and contractility of rat mesenteric small arteries.
Topics: Animals; Antihypertensive Agents; Calcium; Felodipine; In Vitro Techniques; Ion Channels; Membrane P | 1984 |
Interaction of the antihypertensive drug felodipine with calmodulin.
Topics: Animals; Antihypertensive Agents; Cadmium; Calcium; Calcium-Binding Proteins; Calmodulin; Felodipine | 1981 |
Effects of calcium channel antagonists and pertussis toxin on noradrenaline-induced contractions in pulmonary artery from pulmonary hypertensive rats.
Topics: Animals; Aorta; Cadmium; Calcium Channel Blockers; Felodipine; Hypertension, Pulmonary; Male; Monocr | 1995 |
Effects of felodipine, nifedipine and verapamil on cytosolic Ca2+ and contraction in vascular smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1993 |
Membrane stretch evoked by cell swelling increases contractile activity in vascular smooth muscle through dihydropyridine-sensitive pathways.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Membrane; Cell Size; Dihydropyridines; Diltiazem; F | 1994 |
Effects of nimodipine, felodipine, and verapamil on isolated human arteries.
Topics: Adult; Calcium Chloride; Felodipine; Female; Humans; In Vitro Techniques; Male; Mesenteric Arteries; | 1995 |
Effects of chronic receptor blockade on excitation-contraction coupling in rat aortic rings.
Topics: Alkaloids; Animals; Caffeine; Calcium; Cholera Toxin; Felodipine; GTP-Binding Proteins; In Vitro Tec | 1994 |
Felodipine and vasomotion physiology.
Topics: Animals; Aorta; Calcium; Catecholamines; Cattle; Felodipine; Female; Heart; Liver; Mice; Muscle Cont | 1993 |
Effects of 8-bromoguanosine 3':5'-cyclic monophosphate on phenylephrine-induced phosphatidylinositol hydrolysis and contraction in rat caudal artery.
Topics: Animals; Arteries; Buffers; Calcium; Calcium Channel Blockers; Cyclic GMP; Drug Interactions; Felodi | 1995 |
Effects of 5HT2 receptor antagonists on responses to potassium depolarization in rat isolated aorta.
Topics: Animals; Aorta, Thoracic; Cinnarizine; Cyproheptadine; Diltiazem; Drug Synergism; Felodipine; Female | 1997 |
Cardiovascular and renal effects of the combination of felodipine and metoprolol during a high-salt and a moderate-salt diet in spontaneously hypertensive rats.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Calcium Channel Blockers; Drug Therapy, Combin | 1997 |
Influence of chloride ions on alpha1-adrenoceptor mediated contraction and Ca2+ influx in rat caudal artery.
Topics: Animals; Calcium; Chloride Channels; Chlorides; Cyclic GMP; Felodipine; Male; Muscle Contraction; Mu | 1999 |
Modulation of the Ca2+ channel voltage sensor and excitation-contraction coupling by silver.
Topics: Animals; Biophysical Phenomena; Biophysics; Calcium Channels; Electrochemistry; Felodipine; In Vitro | 1992 |
Silver-induced frog skeletal muscle contraction and its modulation by calcium antagonists nifedipine and felodipine and calcium agonist Bay K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
Effects of felodipine on vascular smooth muscle in comparison with nifedipine.
Topics: Animals; Aorta, Thoracic; Caffeine; Calcium; Felodipine; Femoral Artery; In Vitro Techniques; Male; | 1991 |
Increased relaxation by felodipine on pulmonary artery from rats with monocrotaline-induced pulmonary hypertension does not reflect functional impairment of the endothelium.
Topics: Animals; Drug Interactions; Endothelins; Endothelium, Vascular; Felodipine; Hypertension, Pulmonary; | 1991 |
Antagonistic effects of dihydropyridines and verapamil on CaCl2 and 5-HT-evoked contraction in porcine coronary artery.
Topics: Animals; Calcium Chloride; Coronary Vessels; Dihydropyridines; Felodipine; In Vitro Techniques; Musc | 1991 |
Effect of felodipine on the myogenic response to dynamic stretch in vascular smooth muscle.
Topics: Action Potentials; Animals; Calcium; Felodipine; In Vitro Techniques; Male; Muscle Contraction; Musc | 1991 |
Metabolic correlates to pacemaker activity in the smooth muscle of guinea-pig mesotubarium.
Topics: Adenosine Triphosphate; Animals; Biological Clocks; Biological Transport, Active; Felodipine; Female | 1991 |
Endothelin modulation of neuroeffector transmission in rat and guinea pig vas deferens.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Adenosine Triphosphate; Animals; Auton | 1990 |
Effect of felodipine on resistance vessels from spontaneously hypertensive and normotensive rats.
Topics: Animals; Calcium; Felodipine; Hypertension; Muscle Contraction; Nifedipine; Norepinephrine; Rats; Ra | 1985 |
Effects of felodipine on local and neurogenic control of vascular resistance.
Topics: Animals; Cats; Electric Stimulation; Felodipine; Female; Male; Muscle Contraction; Muscle, Smooth, V | 1987 |
Vascular versus myocardial selectivity of calcium antagonists studied by concentration-time-effect relations.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Felodipine; In Vitro | 1987 |
Felodipine actions on vascular muscle Ca2+ channels.
Topics: Animals; Calcium; Cells, Cultured; Drug Interactions; Felodipine; Ion Channels; Membrane Potentials; | 1987 |
Felodipine analogs: structure-activity relationships.
Topics: Administration, Oral; Animals; Blood Pressure; Felodipine; In Vitro Techniques; Muscle Contraction; | 1987 |
Photoaffinity labeling of felodipine-binding proteins in vascular smooth muscle.
Topics: Affinity Labels; Animals; Felodipine; In Vitro Techniques; Muscle Contraction; Muscle Proteins; Musc | 1987 |
Functional antagonism of noradrenaline responses by felodipine and other calcium antagonists in vascular smooth muscles.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Felodipine; Female; In Vitro Techniques; Male; M | 1987 |
Felodipine sensitivity in vivo and in vitro of activation pathways in vascular smooth muscles.
Topics: Action Potentials; Animals; Cats; Drug Resistance; Felodipine; In Vitro Techniques; Muscle Contracti | 1987 |
Studies on the site of the interaction between alpha 1-adrenoceptors and 5-HT2 receptors in rat tail arteries.
Topics: Animals; Arteries; Binding Sites; Diltiazem; Felodipine; In Vitro Techniques; Male; Manganese; Muscl | 1988 |
Effect of felodipine on blood pressure and vascular reactivity in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Felodipine; Hypertension; Muscle Contraction; Mus | 1989 |
Manganese can inhibit or potentiate contractile responses in mesenteric portal vein.
Topics: Animals; Barium; Calcium; Felodipine; Gallopamil; In Vitro Techniques; Male; Manganese; Mesenteric V | 1988 |
Effects of felodipine on energy turnover in the rat portal vein.
Topics: Adenine Nucleotides; Animals; Energy Metabolism; Felodipine; Male; Muscle Contraction; Muscle, Smoot | 1988 |
Low potency of Ca antagonists in smooth muscle from different levels of the respiratory tract.
Topics: Animals; Bronchi; Calcium Channel Blockers; Felodipine; Female; Gallopamil; Guinea Pigs; In Vitro Te | 1987 |
Vascular selectivity of felodipine.
Topics: Animals; Antihypertensive Agents; Calcium Channel Blockers; Dogs; Felodipine; Heart; Hemodynamics; I | 1985 |