felodipine has been researched along with Heart Disease, Ischemic in 16 studies
Felodipine: A dihydropyridine calcium antagonist with positive inotropic effects. It lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels.
felodipine : The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To assess the efficacy and safety of the calcium channel blocker, felodipine, and isosorbide mononitrate (ISMN), as adjunct to optimal beta-blocker therapy in elderly patients, a placebo-controlled, double-blind study was conducted in 46 patients, aged between 65 and 80 years, with documented stress-induced angina pectoris and myocardial ischemia." | 9.07 | Comparison between felodipine and isosorbide mononitrate as adjunct to beta blockade in patients > 65 years of age with angina pectoris. ( de Vries, RJ; Dunselman, PH; Lie, KI; van den Heuvel, AF; van Veldhuisen, DJ; Wielenga, RP, 1994) |
| "To compare the negative inotropic effects of the four dihydropyridine-calcium-channel-blockers nifedipine (NIF), isradipine (ISR), nisoldipine (NIS) and felodipine (FEL) in man, the drugs were infused within 30 min intravenously in an equihypotensive dosage (NIF 2 mg, ISR 0." | 6.67 | [Comparison of the cardiodepressive effects of nifedipine, isradipine, nisoldipine and felodipine in patients with coronary heart disease]. ( Ickrath, O; Karsch, KR; Mauser, M; Voelker, W, 1993) |
| " To assess the efficacy and safety of the calcium channel blocker, felodipine, and isosorbide mononitrate (ISMN), as adjunct to optimal beta-blocker therapy in elderly patients, a placebo-controlled, double-blind study was conducted in 46 patients, aged between 65 and 80 years, with documented stress-induced angina pectoris and myocardial ischemia." | 5.07 | Comparison between felodipine and isosorbide mononitrate as adjunct to beta blockade in patients > 65 years of age with angina pectoris. ( de Vries, RJ; Dunselman, PH; Lie, KI; van den Heuvel, AF; van Veldhuisen, DJ; Wielenga, RP, 1994) |
| "In 102 patients with high risk (52 patients with history of myocardial infarction, 50 patients with history of cerebral stroke within previous 6-48 months) arterial hypertension (AH) we studied clinical efficacy on angiotensin converting enzyme inhibitor (ACEI) lisinopril, calcium antagonist felodipine, and nonselective - -blocker carvedilol in dependence on salt sensitivity of AH." | 3.76 | [Comparative eficacy of antihypertensive therapy in patients with arterial hypertension and various sensitivity to salt]. ( Babkin, AP; Gladkikh, VV; Gulaia, GI; Pershukov, IV, 2010) |
| "Electron paramagnetic resonance (EPR) spectroscopy was used to investigate the gamma-radiation damage in the crystalline powder form of nine calcium channel blockers from the 1,4-dihydropyridine derivatives, which are in clinical use for treatment of arteria hypertension and ischemic heart disease." | 3.74 | The effect of ionizing radiation of 1,4-dihydropyridine derivatives in the solid state. ( Mielcarek, J; Naskrent, M, 2007) |
| "The calcium antagonist felodipine, the lipid-peroxidation inhibitor H290/51, and the angiotensin II type 1 (AT1)-receptor antagonist candesartan all exert beneficial effects on myocardial ischemia/reperfusion injury." | 3.70 | Combination of a calcium antagonist, a lipid-peroxidation inhibitor, and an angiotensin AT1-receptor antagonist provides additive myocardial infarct size-limiting effect in pigs. ( Rydén, L; Shimizu, M; Sjöquist, PO; Wang, QD, 1999) |
| " The purpose of this study was to assess the effects of felodipine as a potentially protective agent against myocardial ischemia and reperfusion injury, independent of any negative inotropic actions, when given after the onset of low-flow ischemia." | 3.69 | Beneficial effects of felodipine on myocardial and coronary function during low-flow ischemia and reperfusion. ( Apstein, CS; Bernstein, EA; Eberli, FR; Horowitz, GL; Silverman, AM, 1996) |
| "To compare the negative inotropic effects of the four dihydropyridine-calcium-channel-blockers nifedipine (NIF), isradipine (ISR), nisoldipine (NIS) and felodipine (FEL) in man, the drugs were infused within 30 min intravenously in an equihypotensive dosage (NIF 2 mg, ISR 0." | 2.67 | [Comparison of the cardiodepressive effects of nifedipine, isradipine, nisoldipine and felodipine in patients with coronary heart disease]. ( Ickrath, O; Karsch, KR; Mauser, M; Voelker, W, 1993) |
| "Treatment with felodipine at 10(-10) and 10(-9) M had no effect on the hearts when perfused under aerobic conditions, whilst the higher dose reduced developed pressure from 57." | 1.29 | Effects of felodipine on the ischemic heart: insight into the mechanism of cytoprotection. ( Benigno, M; Bernocchi, P; Cargnoni, A; Ceconi, C; Ferrari, R; Gaia, G; Pasini, E; Pedersini, P, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (81.25) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Musikhina, NA | 1 |
| Iuferova, OV | 1 |
| Gapon, LI | 1 |
| Makhneva, EA | 1 |
| Belikova, EA | 1 |
| Petelina, TI | 1 |
| Todosiĭchuk, VV | 1 |
| Babkin, AP | 1 |
| Gladkikh, VV | 1 |
| Pershukov, IV | 1 |
| Gulaia, GI | 1 |
| Naskrent, M | 1 |
| Mielcarek, J | 1 |
| Haga, Y | 2 |
| Uriuda, Y | 2 |
| Björkman, JA | 1 |
| Hatori, N | 2 |
| Johansson, L | 1 |
| Nordlander, R | 3 |
| Sjöquist, PO | 5 |
| Rydén, L | 5 |
| Trenkwalder, P | 1 |
| Dobrindt, R | 1 |
| Aulehner, R | 1 |
| Lydtin, H | 1 |
| de Vries, RJ | 1 |
| Dunselman, PH | 1 |
| van Veldhuisen, DJ | 1 |
| van den Heuvel, AF | 1 |
| Wielenga, RP | 1 |
| Lie, KI | 1 |
| Chimienti, M | 1 |
| Negroni, MS | 1 |
| Pusineri, E | 1 |
| Regazzi, MB | 1 |
| Inglese, L | 1 |
| Klersy, C | 1 |
| De Ambroggi, L | 1 |
| Nordlander, M | 1 |
| Mauser, M | 1 |
| Voelker, W | 1 |
| Ickrath, O | 1 |
| Karsch, KR | 1 |
| Bernstein, EA | 1 |
| Eberli, FR | 1 |
| Silverman, AM | 1 |
| Horowitz, GL | 1 |
| Apstein, CS | 1 |
| Wang, QD | 3 |
| Li, XS | 1 |
| Ferrari, R | 1 |
| Cargnoni, A | 1 |
| Bernocchi, P | 1 |
| Gaia, G | 1 |
| Benigno, M | 1 |
| Pasini, E | 1 |
| Pedersini, P | 1 |
| Ceconi, C | 1 |
| Russo, R | 1 |
| Rao, MA | 1 |
| Romano, M | 1 |
| Scotto di Santolo, M | 1 |
| Cardei, S | 1 |
| Giunta, A | 1 |
| Cuocolo, A | 1 |
| Volpe, M | 1 |
| Koenig, W | 1 |
| Höher, M | 1 |
| Shimizu, M | 2 |
5 trials available for felodipine and Heart Disease, Ischemic
| Article | Year |
|---|---|
[Structural-functional properties of the vascular wall in hypertensive patients with coronary heart disease: effects of felodipin and perindopril].
Topics: Antihypertensive Agents; Arteries; Endothelium, Vascular; Felodipine; Humans; Hypertension; Middle A | 2009 |
Antihypertensive treatment with felodipine but not with a diuretic reduces episodes of myocardial ischaemia in elderly patients with hypertension.
Topics: Aged; Aged, 80 and over; Double-Blind Method; Drug Therapy, Combination; Felodipine; Female; Hemodyn | 1994 |
Comparison between felodipine and isosorbide mononitrate as adjunct to beta blockade in patients > 65 years of age with angina pectoris.
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Cross-Over Studies; Delayed-Action Preparations; | 1994 |
[Comparison of the cardiodepressive effects of nifedipine, isradipine, nisoldipine and felodipine in patients with coronary heart disease].
Topics: Adult; Aged; Calcium Channel Blockers; Coronary Disease; Electrocardiography; Exercise Test; Felodip | 1993 |
Felodipine and amlodipine in stable angina pectoris: results of a randomized double-blind crossover trial.
Topics: Adult; Aged; Aged, 80 and over; Amlodipine; Angina Pectoris; Blood Pressure; Calcium Channel Blocker | 1997 |
11 other studies available for felodipine and Heart Disease, Ischemic
| Article | Year |
|---|---|
[Comparative eficacy of antihypertensive therapy in patients with arterial hypertension and various sensitivity to salt].
Topics: Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Carbazoles; Carvedil | 2010 |
The effect of ionizing radiation of 1,4-dihydropyridine derivatives in the solid state.
Topics: Calcium Channel Blockers; Dihydropyridines; Electron Spin Resonance Spectroscopy; Felodipine; Gamma | 2007 |
Ischemic and nonischemic tissue concentrations of felodipine after coronary venous retroinfusion during myocardial ischemia and reperfusion: an experimental study in pigs.
Topics: Animals; Felodipine; Female; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Swine | 1994 |
Once daily felodipine in preventing ergonovine-induced myocardial ischaemia in Prinzmetal's variant angina.
Topics: Aged; Angina Pectoris, Variant; Coronary Angiography; Delayed-Action Preparations; Drug Administrati | 1994 |
Coronary venous retroinfusion of felodipine reducing infarct size without affecting regional myocardial blood flow.
Topics: Animals; Coronary Circulation; Coronary Vessels; Felodipine; Female; Hemodynamics; Infusions, Intrav | 1993 |
Beneficial effects of felodipine on myocardial and coronary function during low-flow ischemia and reperfusion.
Topics: Adenosine Triphosphate; Animals; Calcium Channel Blockers; Coronary Circulation; Dose-Response Relat | 1996 |
Coronary venous drug infusion in the ischaemic-reperfused isolated rat heart.
Topics: Animals; Calcium Channel Blockers; Coronary Circulation; Disease Models, Animal; Felodipine; Heart R | 1996 |
Effects of felodipine on the ischemic heart: insight into the mechanism of cytoprotection.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Calcium; Calcium Channel Blockers; Dose-Respo | 1996 |
[Prospects of pharmacologic treatment of post-ischemic heart failure].
Topics: Calcium Channel Blockers; Felodipine; Female; Heart Failure; Humans; Male; Middle Aged; Myocardial I | 1995 |
Effects of the angiotensin AT1 receptor blocker candesartan on myocardial ischemic/reperfusion injury.
Topics: Angiotensin Receptor Antagonists; Animals; Antioxidants; Benzimidazoles; Biphenyl Compounds; Calcium | 1999 |
Combination of a calcium antagonist, a lipid-peroxidation inhibitor, and an angiotensin AT1-receptor antagonist provides additive myocardial infarct size-limiting effect in pigs.
Topics: Anesthesia; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Antioxidants; Benzim | 1999 |