felodipine has been researched along with Disease Models, Animal in 13 studies
Felodipine: A dihydropyridine calcium antagonist with positive inotropic effects. It lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels.
felodipine : The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Felodipine has a protective effect on the myocardium and kidney as evidenced by decreased perivascular inflammation, myocardial necrosis and fibrosis." | 5.36 | Effect of felodipine on myocardial and renal injury induced by aldosterone-high salt hypertension in uninephrectomized rats. ( Franco, M; Janicki, JS; Matsubara, BB; Matsubara, LS, 2010) |
| "Postmenopausal osteoporosis is one of the most common types of osteoporosis resulting from estrogen deficiency in elderly women." | 1.56 | Felodipine blocks osteoclast differentiation and ameliorates estrogen-dependent bone loss in mice by modulating p38 signaling pathway. ( Huo, S; Li, H; Nie, B; Qu, X; Tang, H; Yue, B; Zhang, S, 2020) |
| "Felodipine has a protective effect on the myocardium and kidney as evidenced by decreased perivascular inflammation, myocardial necrosis and fibrosis." | 1.36 | Effect of felodipine on myocardial and renal injury induced by aldosterone-high salt hypertension in uninephrectomized rats. ( Franco, M; Janicki, JS; Matsubara, BB; Matsubara, LS, 2010) |
| "5." | 1.29 | omega-Conotoxin GVIA and prazosin, but not felodipine, cause postural hypotension in rabbits. ( Angus, JA; Hawkes, AL; Wright, CE, 1995) |
| "This felodipine effect was stronger and longer lasting than the nifedipine one." | 1.28 | [Antihypertensive effect of felodipine, a new calcium antagonist]. ( Hayashi, S; Inoue, T; Inukai, T; Nakao, K; Odagiri, N; Omosu, M; Ono, T; Sakaguchi, S, 1992) |
| "Acute renal failure was induced in pentobarbital anesthetized dogs either by withdrawal of the blood and/or by acute renal artery occlusion and efficacy of felodipine in preserving renal function was evaluated." | 1.28 | Evaluation of the efficacy of felodipine in two models of acute renal failure in dogs. ( Chintala, MS; Jandhyala, BS, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 6 (46.15) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 2 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Zhang, S | 1 |
| Li, H | 1 |
| Tang, H | 1 |
| Huo, S | 1 |
| Nie, B | 1 |
| Qu, X | 1 |
| Yue, B | 1 |
| Siddiqi, FH | 1 |
| Menzies, FM | 1 |
| Lopez, A | 1 |
| Stamatakou, E | 1 |
| Karabiyik, C | 1 |
| Ureshino, R | 1 |
| Ricketts, T | 1 |
| Jimenez-Sanchez, M | 1 |
| Esteban, MA | 1 |
| Lai, L | 1 |
| Tortorella, MD | 1 |
| Luo, Z | 1 |
| Liu, H | 1 |
| Metzakopian, E | 1 |
| Fernandes, HJR | 1 |
| Bassett, A | 1 |
| Karran, E | 1 |
| Miller, BL | 1 |
| Fleming, A | 1 |
| Rubinsztein, DC | 1 |
| Coman, OA | 1 |
| Savu, OR | 1 |
| Ghiţă, I | 1 |
| Păunescu, H | 1 |
| Coman, L | 1 |
| Fulga, I | 1 |
| Matsubara, BB | 1 |
| Franco, M | 1 |
| Janicki, JS | 1 |
| Matsubara, LS | 1 |
| Mulvany, MJ | 1 |
| Korsgaard, N | 1 |
| Nyborg, N | 1 |
| Hawkes, AL | 1 |
| Angus, JA | 1 |
| Wright, CE | 1 |
| Uriuda, Y | 1 |
| Wang, QD | 1 |
| Li, XS | 1 |
| Sjoquist, PO | 1 |
| Nordlander, R | 1 |
| Ryden, L | 1 |
| Rose, J | 1 |
| Heusch, G | 1 |
| Griffin, KA | 1 |
| Picken, MM | 1 |
| Bakris, GL | 1 |
| Bidani, AK | 1 |
| Inoue, T | 1 |
| Omosu, M | 1 |
| Hayashi, S | 1 |
| Sakaguchi, S | 1 |
| Nakao, K | 1 |
| Inukai, T | 1 |
| Odagiri, N | 1 |
| Ono, T | 1 |
| Chintala, MS | 1 |
| Jandhyala, BS | 1 |
13 other studies available for felodipine and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Felodipine blocks osteoclast differentiation and ameliorates estrogen-dependent bone loss in mice by modulating p38 signaling pathway.
Topics: Animals; Bone Diseases, Metabolic; Bone Resorption; Cell Differentiation; Disease Models, Animal; Es | 2020 |
Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing.
Topics: alpha-Synuclein; Animals; Animals, Genetically Modified; Autophagy; Cell Line; Cerebral Cortex; Dise | 2019 |
[Effects of serotonin on reactivity of ocular vasculature].
Topics: Animals; Arteries; Ciliary Arteries; Conjunctiva; Disease Models, Animal; Felodipine; Iris; Male; Ra | 2007 |
Effect of felodipine on myocardial and renal injury induced by aldosterone-high salt hypertension in uninephrectomized rats.
Topics: Aldosterone; Animals; Blood Pressure; Calcium Channel Blockers; Disease Models, Animal; Felodipine; | 2010 |
Evidence that the increased calcium sensitivity of resistance vessels in spontaneously hypertensive rats is an intrinsic defect of their vascular smooth muscle.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium; Disease Models, Animal; Felodipine; Hyper | 1981 |
omega-Conotoxin GVIA and prazosin, but not felodipine, cause postural hypotension in rabbits.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Antihypertensive Agents; Blood Pressure | 1995 |
Coronary venous drug infusion in the ischaemic-reperfused isolated rat heart.
Topics: Animals; Calcium Channel Blockers; Coronary Circulation; Disease Models, Animal; Felodipine; Heart R | 1996 |
Attenuation of regional myocardial stunning by felodipine.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Disease Models, Animal; Dog | 1996 |
Class differences in the effects of calcium channel blockers in the rat remnant kidney model.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Diltiazem; Disease Models, Animal; Drinking; Felo | 1999 |
[Antihypertensive effect of felodipine, a new calcium antagonist].
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Di | 1992 |
Evaluation of the efficacy of felodipine in two models of acute renal failure in dogs.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Felodipine | 1992 |