felodipine has been researched along with Cardiovascular Stroke in 16 studies
Felodipine: A dihydropyridine calcium antagonist with positive inotropic effects. It lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels.
felodipine : The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The role of felodipine, a new calcium antagonist, in monotherapy for mild and moderate hypertension was investigated in a placebo-controlled double-blind study of 109 patients from 13 centres." | 9.06 | Monotherapy with felodipine, a new calcium antagonist, in mild and moderate hypertension. ( Barnes, PC; Bowles, RM; Comerford, MB; Ginks, SE; Ginks, WR; Goves, JR; Grabau, WJ; Hamilton, DV; Malcolm, JP; Rajaratnam, DV, 1987) |
| "All clinical studies of at least 1 week's duration with felodipine in patients with hypertension were included in a safety analysis." | 7.69 | Overview of the safety of felodipine based on clinical trials in patients with hypertension. ( Elmfeldt, D; Elvelin, L; Niklasson, A; Olsson, G; Welin, L, 1997) |
| "The effect of the vasoselective calcium antagonist felodipine on myocardial necrosis was studied in 14 anesthetized pigs subjected to 45-min occlusion of the left anterior descending coronary artery (LAD) followed by 24-h reperfusion." | 7.68 | Coronary venous retroinfusion of felodipine reduces myocardial necrosis after coronary occlusion and reperfusion. ( Haga, Y; Hatori, N; Nordlander, M; Rydén, L; Sjöquist, PO, 1993) |
| " All patients were randomly assigned to take aspirin 75 mg/day or placebo, and patients in the aspirin group had a 15% lower rate of major cardiovascular events and myocardial infarctions than did patients who received placebo." | 6.19 | Aggressive blood pressure lowering is safe, but benefit is still hard to prove. ( Pohl, MA; Vidt, DG, 1999) |
| " the level of blood pressure associated with the lowest incidence of major cardiovascular events such as fatal and non-fatal stroke and myocardial infarction and other cardiovascular mortality); and (2) to assess the effect of a low dose of acetylsalicylic acid (aspirin) compared with placebo on major cardiovascular events." | 5.09 | The Hypertension Optimal Treatment study and the importance of lowering blood pressure. ( Hansson, L, 1999) |
| "The role of felodipine, a new calcium antagonist, in monotherapy for mild and moderate hypertension was investigated in a placebo-controlled double-blind study of 109 patients from 13 centres." | 5.06 | Monotherapy with felodipine, a new calcium antagonist, in mild and moderate hypertension. ( Barnes, PC; Bowles, RM; Comerford, MB; Ginks, SE; Ginks, WR; Goves, JR; Grabau, WJ; Hamilton, DV; Malcolm, JP; Rajaratnam, DV, 1987) |
| "The calcium antagonist felodipine, the lipid-peroxidation inhibitor H290/51, and the angiotensin II type 1 (AT1)-receptor antagonist candesartan all exert beneficial effects on myocardial ischemia/reperfusion injury." | 3.70 | Combination of a calcium antagonist, a lipid-peroxidation inhibitor, and an angiotensin AT1-receptor antagonist provides additive myocardial infarct size-limiting effect in pigs. ( Rydén, L; Shimizu, M; Sjöquist, PO; Wang, QD, 1999) |
| "All clinical studies of at least 1 week's duration with felodipine in patients with hypertension were included in a safety analysis." | 3.69 | Overview of the safety of felodipine based on clinical trials in patients with hypertension. ( Elmfeldt, D; Elvelin, L; Niklasson, A; Olsson, G; Welin, L, 1997) |
| "The effect of the vasoselective calcium antagonist felodipine on myocardial necrosis was studied in 14 anesthetized pigs subjected to 45-min occlusion of the left anterior descending coronary artery (LAD) followed by 24-h reperfusion." | 3.68 | Coronary venous retroinfusion of felodipine reduces myocardial necrosis after coronary occlusion and reperfusion. ( Haga, Y; Hatori, N; Nordlander, M; Rydén, L; Sjöquist, PO, 1993) |
| "Myocardial infarction was induced by a 30-min occlusion of a branch of the left coronary artery, followed by 3-h reperfusion." | 1.30 | Hemodynamic changes do not mediate the cardioprotection induced by the A1, adenosine receptor agonist CCPA in the rabbit. ( Casati, C; Forlani, A; Lozza, G; Monopoli, A, 1997) |
| "For many years the pharmacological treatment of heart failure patients was based on the increase in inotropism through the digitalis and on the reduction in sodium-water retention through diuretics, while less importance was given to the improvement of the afterload." | 1.29 | [The role of ACE inhibitors in heart failure. Lessons of CONSENSUS, SOLVD and V-HeFTII]. ( Dessì-Fulgheri, P; Paci, MV; Rappelli, A, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (12.50) | 18.7374 |
| 1990's | 13 (81.25) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jönsson, B | 1 |
| Hansson, L | 2 |
| Stålhammar, NO | 1 |
| Hatori, N | 2 |
| Haga, Y | 2 |
| Sjöquist, PO | 3 |
| Nordlander, M | 2 |
| Rydén, L | 3 |
| Dessì-Fulgheri, P | 1 |
| Paci, MV | 1 |
| Rappelli, A | 1 |
| Nordlander, R | 1 |
| Lewis, BS | 1 |
| Bonaduce, D | 1 |
| Petretta, M | 1 |
| Ianniciello, A | 1 |
| Apicella, C | 1 |
| Cavallaro, V | 1 |
| Marciano, F | 1 |
| Welin, L | 1 |
| Elvelin, L | 1 |
| Niklasson, A | 1 |
| Olsson, G | 1 |
| Elmfeldt, D | 1 |
| Casati, C | 1 |
| Forlani, A | 1 |
| Lozza, G | 1 |
| Monopoli, A | 1 |
| Parving, HH | 1 |
| Evans, MF | 1 |
| Vidt, DG | 1 |
| Pohl, MA | 1 |
| Fink, KS | 1 |
| Ellsworth, A | 1 |
| Shimizu, M | 1 |
| Wang, QD | 1 |
| Hamilton, DV | 1 |
| Barnes, PC | 1 |
| Bowles, RM | 1 |
| Rajaratnam, DV | 1 |
| Comerford, MB | 1 |
| Ginks, WR | 1 |
| Ginks, SE | 1 |
| Goves, JR | 1 |
| Grabau, WJ | 1 |
| Malcolm, JP | 1 |
| Curtis, MJ | 1 |
| Johnston, KM | 1 |
| Macleod, BA | 1 |
| Walker, MJ | 1 |
2 reviews available for felodipine and Cardiovascular Stroke
| Article | Year |
|---|---|
Calcium antagonists in patients with left ventricular dysfunction: back on the bridge?
Topics: Amlodipine; Calcium Channel Blockers; Felodipine; Humans; Myocardial Infarction; Ventricular Dysfunc | 1996 |
Aggressive blood pressure lowering is safe, but benefit is still hard to prove.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Anti | 1999 |
6 trials available for felodipine and Cardiovascular Stroke
| Article | Year |
|---|---|
Health economics in the Hypertension Optimal Treatment (HOT) study: costs and cost-effectiveness of intensive blood pressure lowering and low-dose aspirin in patients with hypertension.
Topics: Aged; Antihypertensive Agents; Aspirin; Blood Pressure; Calcium Channel Blockers; Cost-Benefit Analy | 2003 |
Comparison of verapamil versus felodipine on heart rate variability after acute myocardial infarction.
Topics: Blood Pressure; Calcium Channel Blockers; Delayed-Action Preparations; Electrocardiography, Ambulato | 1997 |
Do intensive blood pressure lowering and low-dose ASA help our hypertensive patients?
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Anti | 1998 |
Aggressive blood pressure lowering is safe, but benefit is still hard to prove.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Anti | 1999 |
The Hypertension Optimal Treatment study and the importance of lowering blood pressure.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Anti | 1999 |
Monotherapy with felodipine, a new calcium antagonist, in mild and moderate hypertension.
Topics: Administration, Oral; Adult; Aged; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Fel | 1987 |
9 other studies available for felodipine and Cardiovascular Stroke
| Article | Year |
|---|---|
Coronary venous retroinfusion of felodipine reduces myocardial necrosis after coronary occlusion and reperfusion.
Topics: Animals; Coronary Vessels; Felodipine; Female; Hemodynamics; Infusions, Intravenous; Male; Myocardia | 1993 |
[The role of ACE inhibitors in heart failure. Lessons of CONSENSUS, SOLVD and V-HeFTII].
Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Angiotensin-Converting Enzyme Inhibitors; Clinical | 1994 |
Coronary venous retroinfusion of felodipine reducing infarct size without affecting regional myocardial blood flow.
Topics: Animals; Coronary Circulation; Coronary Vessels; Felodipine; Female; Hemodynamics; Infusions, Intrav | 1993 |
Overview of the safety of felodipine based on clinical trials in patients with hypertension.
Topics: Antihypertensive Agents; Calcium Channel Blockers; Cerebrovascular Disorders; Double-Blind Method; F | 1997 |
Hemodynamic changes do not mediate the cardioprotection induced by the A1, adenosine receptor agonist CCPA in the rabbit.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analysis of Variance; Animals; Antihypertensive Agents | 1997 |
Hypertension Optimal Treatment (HOT) trial.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Aspirin; Blood Pressure; Calcium | 1998 |
Antihypertensive treatment and CHD in the elderly.
Topics: Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; | 1999 |
Combination of a calcium antagonist, a lipid-peroxidation inhibitor, and an angiotensin AT1-receptor antagonist provides additive myocardial infarct size-limiting effect in pigs.
Topics: Anesthesia; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Antioxidants; Benzim | 1999 |
The actions of felodipine on arrhythmias and other responses to myocardial ischaemia in conscious rats.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Coronary Disease; Electrocard | 1985 |