felodipine has been researched along with Cardiomegaly in 10 studies
Felodipine: A dihydropyridine calcium antagonist with positive inotropic effects. It lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels.
felodipine : The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty patients whose systemic hypertension was not controlled with chronic beta-blocker therapy were studied to evaluate the acute (first dose), short-term (4 weeks) and chronic (6 to 12 months) effects of the calcium antagonist felodipine on blood pressure (BP), left ventricular (LV) anatomy and function and on plasma norepinephrine." | 5.07 | Antihypertensive effect of felodipine associated with persistent sympathetic activation and minimal regression of left ventricular hypertrophy. ( Holliwell, DL; Leenen, FH, 1992) |
| "Felodipine is a vascular-selective, dihydropyridine calcium antagonist previously investigated as a conventional tablet formulation administered twice daily." | 3.77 | Felodipine. A review of the pharmacology and therapeutic use of the extended release formulation in cardiovascular disorders. ( Faulds, D; Todd, PA, 1992) |
| "Calcium channel blockers, verapamil or felodipine, were given to genetically obese 6 and 11-month-old female SHHF/Mcc-facp (SHHF: Spontaneous Hypertension Heart Failure) rats for 8 weeks to investigate their effects on glucose and lipid metabolism and obesity." | 3.70 | Comparison of verapamil and felodipine treatment on lipid and glucose metabolism in obese female SHHF/Mcc-facp rats. ( Hoepf, T; McCune, SA; Park, SC; Radin, MJ, 1999) |
| "Renal function and salt and water turnover were studied in SHR during acute and chronic administration of felodipine, which is an efficient antihypertensive vasodilating Ca2+ antagonist." | 1.27 | Renal and cardiovascular effects of acute and chronic administration of felodipine to SHR. ( Di Bona, GF; Ljung, B; Nordlander, M; Thorén, P; Yao, T, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 8 (80.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lundin, SA | 1 |
| Hallbäck-Nordlander, MI | 1 |
| Ledingham, JM | 1 |
| Phelan, EL | 1 |
| Cross, MA | 1 |
| Laverty, R | 1 |
| Park, SC | 1 |
| Radin, MJ | 1 |
| Hoepf, T | 1 |
| McCune, SA | 1 |
| Todd, PA | 1 |
| Faulds, D | 1 |
| Leenen, FH | 1 |
| Holliwell, DL | 1 |
| Wetzchewald, D | 2 |
| Klaus, D | 2 |
| Garanin, G | 2 |
| Lohr, E | 2 |
| Hoffmann, J | 2 |
| Strauer, BE | 1 |
| Cerasola, G | 1 |
| Cottone, S | 1 |
| Nardi, E | 1 |
| Fulantelli, MA | 1 |
| Carone, MB | 1 |
| D'Ignoto, G | 1 |
| Nordlander, M | 1 |
| Di Bona, GF | 1 |
| Ljung, B | 1 |
| Yao, T | 1 |
| Thorén, P | 1 |
1 review available for felodipine and Cardiomegaly
| Article | Year |
|---|---|
Felodipine. A review of the pharmacology and therapeutic use of the extended release formulation in cardiovascular disorders.
Topics: Angina Pectoris; Cardiomegaly; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Drug Interact | 1992 |
3 trials available for felodipine and Cardiomegaly
| Article | Year |
|---|---|
Felodipine. A review of the pharmacology and therapeutic use of the extended release formulation in cardiovascular disorders.
Topics: Angina Pectoris; Cardiomegaly; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Drug Interact | 1992 |
Antihypertensive effect of felodipine associated with persistent sympathetic activation and minimal regression of left ventricular hypertrophy.
Topics: Adult; Aged; Analysis of Variance; Cardiomegaly; Double-Blind Method; Drug Therapy, Combination; Fel | 1992 |
Regression of left ventricular hypertrophy during long-term antihypertensive treatment--a comparison between felodipine and the combination of felodipine and metoprolol.
Topics: Adult; Analysis of Variance; Blood Pressure; Cardiomegaly; Double-Blind Method; Drug Therapy, Combin | 1992 |
7 other studies available for felodipine and Cardiomegaly
| Article | Year |
|---|---|
Regression of structural cardiovascular changes by antihypertensive therapy in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Cardiovascular System; Circadian Rhy | 1984 |
Effect of felodipine treatment and withdrawal on blood pressure and cardiovascular structure in New Zealand genetically hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Cardiovascular System; Felodipine; H | 1995 |
Comparison of verapamil and felodipine treatment on lipid and glucose metabolism in obese female SHHF/Mcc-facp rats.
Topics: Age Factors; Animals; Antihypertensive Agents; Blood Glucose; Blood Pressure; Body Weight; Calcium C | 1999 |
Regression of left ventricular hypertrophy by felodipine or a combination of felodipine and metoprolol.
Topics: Cardiomegaly; Drug Therapy, Combination; Felodipine; Female; Humans; Male; Metoprolol; Middle Aged | 1990 |
Significance of coronary circulation in hypertensive heart disease for development and prevention of heart failure.
Topics: Adult; Animals; Cardiac Output, Low; Cardiomegaly; Coronary Circulation; Coronary Disease; Coronary | 1990 |
Reversal of cardiac hypertrophy and left ventricular function with the calcium antagonist felodipine in hypertensive patients.
Topics: Adult; Calcium; Cardiomegaly; Echocardiography; Felodipine; Female; Humans; Hypertension; Male; Midd | 1990 |
Renal and cardiovascular effects of acute and chronic administration of felodipine to SHR.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Felodipine; Furosemide; Heart Rate; | 1985 |