felodipine has been researched along with Cardiac Hypertrophy in 10 studies
Felodipine: A dihydropyridine calcium antagonist with positive inotropic effects. It lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels.
felodipine : The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.
Cardiac Hypertrophy: Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty patients whose systemic hypertension was not controlled with chronic beta-blocker therapy were studied to evaluate the acute (first dose), short-term (4 weeks) and chronic (6 to 12 months) effects of the calcium antagonist felodipine on blood pressure (BP), left ventricular (LV) anatomy and function and on plasma norepinephrine." | 5.07 | Antihypertensive effect of felodipine associated with persistent sympathetic activation and minimal regression of left ventricular hypertrophy. ( Holliwell, DL; Leenen, FH, 1992) |
| "Felodipine is a vascular-selective, dihydropyridine calcium antagonist previously investigated as a conventional tablet formulation administered twice daily." | 3.77 | Felodipine. A review of the pharmacology and therapeutic use of the extended release formulation in cardiovascular disorders. ( Faulds, D; Todd, PA, 1992) |
| "Calcium channel blockers, verapamil or felodipine, were given to genetically obese 6 and 11-month-old female SHHF/Mcc-facp (SHHF: Spontaneous Hypertension Heart Failure) rats for 8 weeks to investigate their effects on glucose and lipid metabolism and obesity." | 3.70 | Comparison of verapamil and felodipine treatment on lipid and glucose metabolism in obese female SHHF/Mcc-facp rats. ( Hoepf, T; McCune, SA; Park, SC; Radin, MJ, 1999) |
| "Renal function and salt and water turnover were studied in SHR during acute and chronic administration of felodipine, which is an efficient antihypertensive vasodilating Ca2+ antagonist." | 1.27 | Renal and cardiovascular effects of acute and chronic administration of felodipine to SHR. ( Di Bona, GF; Ljung, B; Nordlander, M; Thorén, P; Yao, T, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 8 (80.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lundin, SA | 1 |
| Hallbäck-Nordlander, MI | 1 |
| Ledingham, JM | 1 |
| Phelan, EL | 1 |
| Cross, MA | 1 |
| Laverty, R | 1 |
| Park, SC | 1 |
| Radin, MJ | 1 |
| Hoepf, T | 1 |
| McCune, SA | 1 |
| Todd, PA | 1 |
| Faulds, D | 1 |
| Leenen, FH | 1 |
| Holliwell, DL | 1 |
| Wetzchewald, D | 2 |
| Klaus, D | 2 |
| Garanin, G | 2 |
| Lohr, E | 2 |
| Hoffmann, J | 2 |
| Strauer, BE | 1 |
| Cerasola, G | 1 |
| Cottone, S | 1 |
| Nardi, E | 1 |
| Fulantelli, MA | 1 |
| Carone, MB | 1 |
| D'Ignoto, G | 1 |
| Nordlander, M | 1 |
| Di Bona, GF | 1 |
| Ljung, B | 1 |
| Yao, T | 1 |
| Thorén, P | 1 |
1 review available for felodipine and Cardiac Hypertrophy
| Article | Year |
|---|---|
Felodipine. A review of the pharmacology and therapeutic use of the extended release formulation in cardiovascular disorders.
Topics: Angina Pectoris; Cardiomegaly; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Drug Interact | 1992 |
3 trials available for felodipine and Cardiac Hypertrophy
| Article | Year |
|---|---|
Felodipine. A review of the pharmacology and therapeutic use of the extended release formulation in cardiovascular disorders.
Topics: Angina Pectoris; Cardiomegaly; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Drug Interact | 1992 |
Antihypertensive effect of felodipine associated with persistent sympathetic activation and minimal regression of left ventricular hypertrophy.
Topics: Adult; Aged; Analysis of Variance; Cardiomegaly; Double-Blind Method; Drug Therapy, Combination; Fel | 1992 |
Regression of left ventricular hypertrophy during long-term antihypertensive treatment--a comparison between felodipine and the combination of felodipine and metoprolol.
Topics: Adult; Analysis of Variance; Blood Pressure; Cardiomegaly; Double-Blind Method; Drug Therapy, Combin | 1992 |
7 other studies available for felodipine and Cardiac Hypertrophy
| Article | Year |
|---|---|
Regression of structural cardiovascular changes by antihypertensive therapy in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Cardiovascular System; Circadian Rhy | 1984 |
Effect of felodipine treatment and withdrawal on blood pressure and cardiovascular structure in New Zealand genetically hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Cardiovascular System; Felodipine; H | 1995 |
Comparison of verapamil and felodipine treatment on lipid and glucose metabolism in obese female SHHF/Mcc-facp rats.
Topics: Age Factors; Animals; Antihypertensive Agents; Blood Glucose; Blood Pressure; Body Weight; Calcium C | 1999 |
Regression of left ventricular hypertrophy by felodipine or a combination of felodipine and metoprolol.
Topics: Cardiomegaly; Drug Therapy, Combination; Felodipine; Female; Humans; Male; Metoprolol; Middle Aged | 1990 |
Significance of coronary circulation in hypertensive heart disease for development and prevention of heart failure.
Topics: Adult; Animals; Cardiac Output, Low; Cardiomegaly; Coronary Circulation; Coronary Disease; Coronary | 1990 |
Reversal of cardiac hypertrophy and left ventricular function with the calcium antagonist felodipine in hypertensive patients.
Topics: Adult; Calcium; Cardiomegaly; Echocardiography; Felodipine; Female; Humans; Hypertension; Male; Midd | 1990 |
Renal and cardiovascular effects of acute and chronic administration of felodipine to SHR.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Felodipine; Furosemide; Heart Rate; | 1985 |