felodipine has been researched along with Body Weight in 27 studies
Felodipine: A dihydropyridine calcium antagonist with positive inotropic effects. It lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels.
felodipine : The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The efficacy and tolerability of felodipine and prazosin were compared in a double-blind randomised parallel group study of 100 patients with moderately severe essential hypertension, treated concomitantly with a beta-blocking drug." | 9.06 | Felodipine versus prazosin as an addition to a beta-blocker in the treatment of essential hypertension. The Australian Multicentre Study. ( Anderson, A; Gibson, J; Jackson, B; Morgan, TO, 1987) |
| "The aim of this study was to compare the new vasodilator felodipine with nifedipine in 18 patients with poorly controlled hypertension." | 9.05 | Comparative trial of felodipine and nifedipine in refractory hypertension. ( Aberg, H; Lindsjö, M; Mörlin, B, 1985) |
| "Sibutramine treatment resulted in a significantly greater decrease in body weight, body mass index, and waist circumference and a significant increase in diastolic blood pressure during 24-hour blood pressure monitoring compared with placebo treatment." | 6.73 | Optimal treatment of obesity-related hypertension: the Hypertension-Obesity-Sibutramine (HOS) study. ( Grimm, E; Herrmann, D; Kintscher, U; Scholze, J; Unger, T, 2007) |
| " Altogether, 251 hypertensive patients with a diastolic blood pressure greater than 95 mm Hg after 4 weeks of treatment with placebo in combination with metoprolol CR 100 mg were randomized to four parallel groups." | 6.67 | Optimal felodipine dose when combined with metoprolol in arterial hypertension: a Swedish multicenter study within primary health care. Swedish General Practitioner Felodipine Study Group. ( Bengtsson, C; Brun, J; Fröberg, L; Kronmann, P; Olsson, LB; Scherstén, B; Skoog, P; Tibblin, G; Tygesen, G, 1990) |
| "Felodipine ER once daily was as effective and tolerable as plain tablets b." | 6.67 | Felodipine extended-release tablets once daily are equivalent to plain tablets twice daily in treating hypertension. Dutch Hospital Multicentre Group. ( Hart, W; Westberg, B, 1990) |
| "Hydrochlorothiazide treatment was accompanied by a decrease in serum potassium and an increase in serum uric acid." | 6.67 | The efficacy and tolerability of long-term felodipine treatment in hypertension. The Scandinavian Multicenter Group. ( Ibsen, H; Westberg, B, 1990) |
| "Felodipine (5 mg/kg/d) was then administered by gavage daily for 6 weeks to the felodipine group." | 5.35 | Felodipine downregulates serum interleukin-18 levels in rats with fructose-induced metabolic syndrome. ( Bi, XP; Tan, HW; Xing, SS; Zhang, W; Zhang, Y; Zhong, M, 2009) |
| "The efficacy and tolerability of felodipine and prazosin were compared in a double-blind randomised parallel group study of 100 patients with moderately severe essential hypertension, treated concomitantly with a beta-blocking drug." | 5.06 | Felodipine versus prazosin as an addition to a beta-blocker in the treatment of essential hypertension. The Australian Multicentre Study. ( Anderson, A; Gibson, J; Jackson, B; Morgan, TO, 1987) |
| "The aim of this study was to compare the new vasodilator felodipine with nifedipine in 18 patients with poorly controlled hypertension." | 5.05 | Comparative trial of felodipine and nifedipine in refractory hypertension. ( Aberg, H; Lindsjö, M; Mörlin, B, 1985) |
| "Calcium channel blockers, verapamil or felodipine, were given to genetically obese 6 and 11-month-old female SHHF/Mcc-facp (SHHF: Spontaneous Hypertension Heart Failure) rats for 8 weeks to investigate their effects on glucose and lipid metabolism and obesity." | 3.70 | Comparison of verapamil and felodipine treatment on lipid and glucose metabolism in obese female SHHF/Mcc-facp rats. ( Hoepf, T; McCune, SA; Park, SC; Radin, MJ, 1999) |
| "Both enalapril and felodipine ameliorated adverse cardiovascular effects of hypertension in the aged SHRs within 12 weeks, as demonstrated by reduced arterial pressure, diminished left ventricular mass, and improved coronary hemodynamics." | 3.70 | Pharmacologic agents on cardiovascular mass, coronary dynamics and collagen in aged spontaneously hypertensive rats. ( Frohlich, ED; Susic, D; Varagic, J, 1999) |
| "Sibutramine treatment resulted in a significantly greater decrease in body weight, body mass index, and waist circumference and a significant increase in diastolic blood pressure during 24-hour blood pressure monitoring compared with placebo treatment." | 2.73 | Optimal treatment of obesity-related hypertension: the Hypertension-Obesity-Sibutramine (HOS) study. ( Grimm, E; Herrmann, D; Kintscher, U; Scholze, J; Unger, T, 2007) |
| " Amlodipine did not affect cardiac function in the young, and with chronic dosing decreased the heart rate by 3-5 bpm and the cardiac index by 0." | 2.72 | Sympatho-excitatory responses to once-daily dihydropyridines in young versus older hypertensive patients: amlodipine versus felodipine extended release. ( Coletta, E; Leenen, FH; White, R, 2006) |
| "Felodipine tended to increase U-AQP2, to decrease CH2O and urine volume and GFR, and to increase FENa, but the effect was not significantly different from placebo." | 2.71 | Urinary excretion of aquaporin-2 after furosemide and felodipine in healthy humans. ( Bech, JN; Pedersen, EB; Starklint, J, 2005) |
| " After 12 weeks of active treatment, reductions in supine systolic/diastolic blood pressure 24 h after dosing were 20/14, 13/10 and 11/8 mmHg with felodipine-metoprolol, felodipine and metoprolol, respectively." | 2.67 | Antihypertensive efficacy and tolerability of a new once-daily felodipine-metoprolol combination compared with each component alone. The Swedish/UK Study Group. ( Dahlöf, B; Hosie, J, 1993) |
| " Overall, the withdrawal rate due to adverse events during the first 12 months of treatment was 6." | 2.67 | The long-term antihypertensive efficacy and safety of a new felodipine-metoprolol combination tablet. The Swedish/UK and German Study Groups. ( Dahlöf, B; Hosie, J; Klein, G, 1993) |
| "and felodipine PT b." | 2.67 | Antihypertensive effect and tolerability of felodipine extended release (ER) tablets in comparison with felodipine plain tablets (PT) and placebo in hypertensives on a diuretic. Canadian Study Group. ( Carruthers, SG; Vint-Reed, C, 1993) |
| "Felodipine was completely absorbed from an oral solution (OS), as well as from the conventional (CT) and extended release (ER) tablets." | 2.67 | Felodipine pharmacokinetics and plasma concentration vs effect relationships. ( Blychert, E, 1992) |
| " Altogether, 251 hypertensive patients with a diastolic blood pressure greater than 95 mm Hg after 4 weeks of treatment with placebo in combination with metoprolol CR 100 mg were randomized to four parallel groups." | 2.67 | Optimal felodipine dose when combined with metoprolol in arterial hypertension: a Swedish multicenter study within primary health care. Swedish General Practitioner Felodipine Study Group. ( Bengtsson, C; Brun, J; Fröberg, L; Kronmann, P; Olsson, LB; Scherstén, B; Skoog, P; Tibblin, G; Tygesen, G, 1990) |
| "Felodipine ER once daily was as effective and tolerable as plain tablets b." | 2.67 | Felodipine extended-release tablets once daily are equivalent to plain tablets twice daily in treating hypertension. Dutch Hospital Multicentre Group. ( Hart, W; Westberg, B, 1990) |
| "Hydrochlorothiazide treatment was accompanied by a decrease in serum potassium and an increase in serum uric acid." | 2.67 | The efficacy and tolerability of long-term felodipine treatment in hypertension. The Scandinavian Multicenter Group. ( Ibsen, H; Westberg, B, 1990) |
| "Felodipine (5 mg/kg/d) was then administered by gavage daily for 6 weeks to the felodipine group." | 1.35 | Felodipine downregulates serum interleukin-18 levels in rats with fructose-induced metabolic syndrome. ( Bi, XP; Tan, HW; Xing, SS; Zhang, W; Zhang, Y; Zhong, M, 2009) |
| " In fertility, teratology and peri-postnatal studies Sprague-Dawley rats were dosed by gavage with 10, 25 and 70 mumol/kg (fertility and teratology studies) or 3, 10 and 30 mumol/kg (peri-postnatal study)." | 1.29 | Reproductive toxicity studies of the antihypertensive agent felodipine in the rat. ( Danielson, MK; Danielsson, BR, 1993) |
| "The mechanisms responsible for the resetting of the baroreceptor reflex during long-term administration of 1,4 dihydropyridine calcium channel blockers are incompletely understood." | 1.28 | Baroreceptor activity in man during administration of the calcium channel blocker felodipine. ( Düsing, R; Göbel, B; Lieder, P; Vetter, H; Weisser, B, 1990) |
| " With increasing age the area under the felodipine plasma concentration vs time curve (AUC), the maximum plasma concentration (Cmax), and the terminal elimination half-life of felodipine increased, while the plasma clearance of felodipine decreased." | 1.28 | A population study of the pharmacokinetics of felodipine. ( Blychert, E; Edgar, B; Elmfeldt, D; Hedner, T, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (18.52) | 18.7374 |
| 1990's | 18 (66.67) | 18.2507 |
| 2000's | 4 (14.81) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bi, XP | 1 |
| Tan, HW | 1 |
| Xing, SS | 1 |
| Zhong, M | 1 |
| Zhang, Y | 1 |
| Zhang, W | 1 |
| Starklint, J | 1 |
| Bech, JN | 1 |
| Pedersen, EB | 1 |
| Leenen, FH | 1 |
| Coletta, E | 1 |
| White, R | 1 |
| Scholze, J | 1 |
| Grimm, E | 1 |
| Herrmann, D | 1 |
| Unger, T | 1 |
| Kintscher, U | 1 |
| Hasselgren, B | 1 |
| Johansson, P | 1 |
| Dahlöf, B | 4 |
| Hosie, J | 3 |
| Jönsson, L | 1 |
| Borgholst, O | 1 |
| Ekblad, G | 1 |
| Engstrand, C | 1 |
| Grundestam, I | 1 |
| Lindh, A | 1 |
| Klein, G | 1 |
| Carruthers, SG | 1 |
| Vint-Reed, C | 1 |
| Danielson, MK | 1 |
| Danielsson, BR | 1 |
| Park, SC | 1 |
| Radin, MJ | 1 |
| Hoepf, T | 1 |
| McCune, SA | 1 |
| Susic, D | 1 |
| Varagic, J | 1 |
| Frohlich, ED | 1 |
| Blychert, E | 2 |
| Morgan, TO | 2 |
| Anderson, A | 2 |
| Jones, E | 1 |
| Lund-Johansen, P | 1 |
| Omvik, P | 1 |
| Brun, J | 1 |
| Fröberg, L | 1 |
| Kronmann, P | 1 |
| Olsson, LB | 1 |
| Skoog, P | 1 |
| Tygesen, G | 1 |
| Bengtsson, C | 1 |
| Scherstén, B | 1 |
| Tibblin, G | 1 |
| Hart, W | 1 |
| Westberg, B | 2 |
| Weissel, M | 1 |
| Stanek, B | 1 |
| Flygt, G | 1 |
| Weisser, B | 1 |
| Lieder, P | 1 |
| Göbel, B | 1 |
| Vetter, H | 1 |
| Düsing, R | 1 |
| Ibsen, H | 1 |
| Edgar, B | 1 |
| Elmfeldt, D | 1 |
| Hedner, T | 1 |
| Liedholm, H | 1 |
| Melander, A | 1 |
| Abelardo, NS | 1 |
| Ramos, EF | 1 |
| Mendoza, VL | 1 |
| Sulit, YQ | 1 |
| Mitchell, MJ | 1 |
| Hansson, BG | 1 |
| Lyngstam, G | 1 |
| Lyngstam, O | 1 |
| Rydén, L | 1 |
| Thilén, U | 1 |
| Jackson, B | 1 |
| Gibson, J | 1 |
| Aberg, H | 1 |
| Lindsjö, M | 1 |
| Mörlin, B | 1 |
20 trials available for felodipine and Body Weight
| Article | Year |
|---|---|
Urinary excretion of aquaporin-2 after furosemide and felodipine in healthy humans.
Topics: Adult; Aged; Aquaporin 2; Aquaporins; Body Weight; Felodipine; Female; Furosemide; Health; Humans; M | 2005 |
Sympatho-excitatory responses to once-daily dihydropyridines in young versus older hypertensive patients: amlodipine versus felodipine extended release.
Topics: Adult; Aged; Aged, 80 and over; Aging; Amlodipine; Antihypertensive Agents; Blood Pressure; Body Wei | 2006 |
Optimal treatment of obesity-related hypertension: the Hypertension-Obesity-Sibutramine (HOS) study.
Topics: Adult; Aged; Antihypertensive Agents; Appetite Depressants; Blood Pressure; Body Weight; Cyclobutane | 2007 |
Natriuretic and diuretic effects of felodipine and hydrochlorothiazide after single and repeated doses.
Topics: Adult; Blood Pressure; Body Weight; Cross-Over Studies; Diuresis; Double-Blind Method; Felodipine; H | 1995 |
Antihypertensive efficacy and tolerability of a new once-daily felodipine-metoprolol combination compared with each component alone. The Swedish/UK Study Group.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Weight; Delayed-Action Preparations; Doub | 1993 |
Improved antihypertensive efficacy of the felodipine-metoprolol extended-release tablet compared with each drug alone.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Weight; Delayed-Action Preparations; Doub | 1993 |
The long-term antihypertensive efficacy and safety of a new felodipine-metoprolol combination tablet. The Swedish/UK and German Study Groups.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Weight; Delayed-Action Preparations; Doub | 1993 |
Antihypertensive effect and tolerability of felodipine extended release (ER) tablets in comparison with felodipine plain tablets (PT) and placebo in hypertensives on a diuretic. Canadian Study Group.
Topics: Adult; Aged; Blood Pressure; Body Weight; Canada; Delayed-Action Preparations; Double-Blind Method; | 1993 |
Felodipine pharmacokinetics and plasma concentration vs effect relationships.
Topics: Absorption; Administration, Oral; Adult; Age Factors; Aged; Aged, 80 and over; Biological Availabili | 1992 |
Comparison and interaction of low dose felodipine and enalapril in the treatment of essential hypertension in elderly subjects.
Topics: Aged; Aging; Blood Pressure; Body Weight; Dose-Response Relationship, Drug; Double-Blind Method; Dru | 1992 |
Optimal felodipine dose when combined with metoprolol in arterial hypertension: a Swedish multicenter study within primary health care. Swedish General Practitioner Felodipine Study Group.
Topics: Adult; Aged; Blood Pressure; Body Weight; Delayed-Action Preparations; Double-Blind Method; Drug The | 1990 |
Felodipine extended-release tablets once daily are equivalent to plain tablets twice daily in treating hypertension. Dutch Hospital Multicentre Group.
Topics: Adult; Aged; Blood Pressure; Body Weight; Delayed-Action Preparations; Felodipine; Female; Heart Rat | 1990 |
Felodipine is more effective than hydrochlorothiazide when added to a beta-blocker in treating elderly hypertensive patients.
Topics: Adrenergic beta-Antagonists; Aged; Blood Pressure; Body Weight; Double-Blind Method; Drug Therapy, C | 1990 |
Antihypertensive efficacy and tolerability of a fixed combination of metoprolol and felodipine in comparison with the individual substances in monotherapy. The Swedish/United Kingdom Study Group.
Topics: Adult; Aged; Blood Pressure; Body Weight; Double-Blind Method; Drug Therapy, Combination; Electrocar | 1990 |
The efficacy and tolerability of long-term felodipine treatment in hypertension. The Scandinavian Multicenter Group.
Topics: Adrenergic beta-Antagonists; Adult; Ankle; Blood Pressure; Body Weight; Double-Blind Method; Drug Ad | 1990 |
A placebo-controlled dose-response study of felodipine extended release in hypertensive patients.
Topics: Adult; Aged; Blood Pressure; Body Weight; Calcium Channel Blockers; Clinical Trials as Topic; Dose-R | 1989 |
A comparison of felodipine and nifedipine as monotherapies for the treatment of mild to moderate hypertension.
Topics: Adult; Blood Pressure; Body Weight; Clinical Trials as Topic; Double-Blind Method; Felodipine; Femal | 1989 |
Antihypertensive effect of felodipine combined with beta-blockade. A comparison between 2 and 3 daily dosages.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Weight; Clin | 1985 |
Felodipine versus prazosin as an addition to a beta-blocker in the treatment of essential hypertension. The Australian Multicentre Study.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials a | 1987 |
Comparative trial of felodipine and nifedipine in refractory hypertension.
Topics: Aged; Ankle; Antihypertensive Agents; Blood Pressure; Body Weight; Calcium Channel Blockers; Clinica | 1985 |
7 other studies available for felodipine and Body Weight
| Article | Year |
|---|---|
Felodipine downregulates serum interleukin-18 levels in rats with fructose-induced metabolic syndrome.
Topics: Animal Feed; Animals; Blood Glucose; Blood Pressure; Body Weight; Calcium Channel Blockers; Choleste | 2009 |
Reproductive toxicity studies of the antihypertensive agent felodipine in the rat.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Felodipine; Female; Fertility; Fetus; Labor, Obst | 1993 |
Comparison of verapamil and felodipine treatment on lipid and glucose metabolism in obese female SHHF/Mcc-facp rats.
Topics: Age Factors; Animals; Antihypertensive Agents; Blood Glucose; Blood Pressure; Body Weight; Calcium C | 1999 |
Pharmacologic agents on cardiovascular mass, coronary dynamics and collagen in aged spontaneously hypertensive rats.
Topics: Aging; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Body Weight; Calc | 1999 |
Chronic hemodynamic effects of tiapamil and felodipine in essential hypertension at rest and during exercise.
Topics: Adult; Blood Pressure; Blood Volume; Body Weight; Cardiac Output; Exercise; Felodipine; Heart Rate; | 1990 |
Baroreceptor activity in man during administration of the calcium channel blocker felodipine.
Topics: Adult; Blood Pressure; Body Weight; Electrocardiography; Felodipine; Heart Rate; Humans; Isoproteren | 1990 |
A population study of the pharmacokinetics of felodipine.
Topics: Adult; Aged; Aged, 80 and over; Aging; Antihypertensive Agents; Body Weight; Drug Interactions; Felo | 1991 |