felodipine and Aging
felodipine has been researched along with Aging in 14 studies
Felodipine: A dihydropyridine calcium antagonist with positive inotropic effects. It lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels.
felodipine : The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "The antihypertensive effects of lisinopril 10-20 mg once daily and felodipine (extended release formulation) 5-10 mg once daily were compared in a double-blind, parallel group study of eight weeks duration involving 219 patients with mild to moderate hypertension." | 9.07 | Efficacy and tolerability of lisinopril compared with extended release felodipine in patients with essential hypertension. Danish Cooperative Study Group. ( Jensen, HA, 1992) |
| "To characterize the population dose-response and concentration-response relationships of felodipine and to investigate the influence of patient variables on these relationships." | 6.68 | Felodipine population dose-response and concentration-response relationships in patients with essential hypertension. ( Sambol, NC; Wade, JR, 1995) |
| "The antihypertensive effects of lisinopril 10-20 mg once daily and felodipine (extended release formulation) 5-10 mg once daily were compared in a double-blind, parallel group study of eight weeks duration involving 219 patients with mild to moderate hypertension." | 5.07 | Efficacy and tolerability of lisinopril compared with extended release felodipine in patients with essential hypertension. Danish Cooperative Study Group. ( Jensen, HA, 1992) |
| " This study was designed to determine the effects of aging and AT-1 receptor blockade (losartan 30 mg/kg/day beginning at 8 weeks of age) on NO system in this model." | 3.71 | Effects of aging and AT-1 receptor blockade on NO synthase expression and renal function in SHR. ( Kivlighn, S; Ni, ZN; Shahinfar, S; Vaziri, ND; Wang, XQ, 2002) |
| "Both enalapril and felodipine ameliorated adverse cardiovascular effects of hypertension in the aged SHRs within 12 weeks, as demonstrated by reduced arterial pressure, diminished left ventricular mass, and improved coronary hemodynamics." | 3.70 | Pharmacologic agents on cardiovascular mass, coronary dynamics and collagen in aged spontaneously hypertensive rats. ( Frohlich, ED; Susic, D; Varagic, J, 1999) |
| " Amlodipine did not affect cardiac function in the young, and with chronic dosing decreased the heart rate by 3-5 bpm and the cardiac index by 0." | 2.72 | Sympatho-excitatory responses to once-daily dihydropyridines in young versus older hypertensive patients: amlodipine versus felodipine extended release. ( Coletta, E; Leenen, FH; White, R, 2006) |
| "To characterize the population dose-response and concentration-response relationships of felodipine and to investigate the influence of patient variables on these relationships." | 2.68 | Felodipine population dose-response and concentration-response relationships in patients with essential hypertension. ( Sambol, NC; Wade, JR, 1995) |
| "Felodipine appears to lower blood pressure effectively in the elderly patient with few, generally mild, adverse effects." | 2.38 | Efficacy and safety of felodipine, a new dihydropyridine calcium channel blocker, in elderly hypertensive patients. ( DeQuattro, V, 1992) |
| "A new, once-daily combination tablet containing felodipine and metoprolol has been developed, using extended-release techniques to obtain even plasma concentrations throughout the dosing interval." | 1.29 | Design and pharmacokinetics of Logimax, a new extended-release combination tablet of felodipine and metoprolol. ( Abrahamsson, B; Edgar, B; Lidman, K; Wingstrand, K, 1993) |
| " With increasing age the area under the felodipine plasma concentration vs time curve (AUC), the maximum plasma concentration (Cmax), and the terminal elimination half-life of felodipine increased, while the plasma clearance of felodipine decreased." | 1.28 | A population study of the pharmacokinetics of felodipine. ( Blychert, E; Edgar, B; Elmfeldt, D; Hedner, T, 1991) |
Research
Studies (14)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (14.29) | 18.7374 |
| 1990's | 10 (71.43) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Vaziri, ND | 1 |
| Wang, XQ | 1 |
| Ni, ZN | 1 |
| Kivlighn, S | 1 |
| Shahinfar, S | 1 |
| Leenen, FH | 1 |
| Coletta, E | 1 |
| White, R | 1 |
| Wade, JR | 1 |
| Sambol, NC | 1 |
| Hojo, Y | 1 |
| Ebata, H | 1 |
| Kawasaki, K | 1 |
| Tsuruya, Y | 1 |
| Ikeda, U | 1 |
| Nishinaga, M | 1 |
| Natsume, T | 1 |
| Ishida, H | 1 |
| Shimada, K | 1 |
| Abrahamsson, B | 1 |
| Edgar, B | 3 |
| Lidman, K | 1 |
| Wingstrand, K | 1 |
| Rivas-Cabañero, L | 1 |
| Rodríguez-Barbero, A | 1 |
| Macías-Núñez, JF | 1 |
| López-Novoa, JM | 1 |
| Susic, D | 1 |
| Varagic, J | 1 |
| Frohlich, ED | 1 |
| Jensen, HA | 1 |
| DeQuattro, V | 1 |
| Morgan, TO | 1 |
| Anderson, A | 1 |
| Jones, E | 1 |
| Blychert, E | 1 |
| Elmfeldt, D | 1 |
| Hedner, T | 1 |
| Hosie, J | 1 |
| Mulder, AW | 1 |
| Westberg, B | 1 |
| Regårdh, CG | 1 |
| Olsson, R | 1 |
| Kendall, M | 1 |
| Collste, P | 1 |
| Shansky, C | 1 |
| Wanstall, JC | 1 |
| O'Donnell, SR | 1 |
Reviews
1 review available for felodipine and Aging
| Article | Year |
|---|---|
Efficacy and safety of felodipine, a new dihydropyridine calcium channel blocker, in elderly hypertensive patients.
Topics: Aging; Felodipine; Hemodynamics; Humans; Hypertension; Treatment Outcome | 1992 |
Trials
5 trials available for felodipine and Aging
| Article | Year |
|---|---|
Sympatho-excitatory responses to once-daily dihydropyridines in young versus older hypertensive patients: amlodipine versus felodipine extended release.
Topics: Adult; Aged; Aged, 80 and over; Aging; Amlodipine; Antihypertensive Agents; Blood Pressure; Body Wei | 2006 |
Felodipine population dose-response and concentration-response relationships in patients with essential hypertension.
Topics: Adult; Aged; Aging; Algorithms; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Metho | 1995 |
Efficacy and tolerability of lisinopril compared with extended release felodipine in patients with essential hypertension. Danish Cooperative Study Group.
Topics: Adult; Aged; Aging; Blood Pressure; Delayed-Action Preparations; Dipeptides; Felodipine; Female; Hum | 1992 |
Comparison and interaction of low dose felodipine and enalapril in the treatment of essential hypertension in elderly subjects.
Topics: Aged; Aging; Blood Pressure; Body Weight; Dose-Response Relationship, Drug; Double-Blind Method; Dru | 1992 |
Felodipine once daily in elderly hypertensives. Binational MC Study Group (United Kingdom and Netherlands).
Topics: Aged; Aging; Blood Pressure; Delayed-Action Preparations; Felodipine; Humans; Hypertension | 1991 |
Other Studies
8 other studies available for felodipine and Aging
| Article | Year |
|---|---|
Effects of aging and AT-1 receptor blockade on NO synthase expression and renal function in SHR.
Topics: Aging; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pr | 2002 |
Altered levels of erythrocyte calcium-binding proteins in essential hypertensives with genetic predisposition: correlation with ambulatory blood pressure.
Topics: Aging; Ambulatory Care; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Cytos | 1994 |
Design and pharmacokinetics of Logimax, a new extended-release combination tablet of felodipine and metoprolol.
Topics: Adult; Aged; Aging; Biological Availability; Delayed-Action Preparations; Drug Combinations; Felodip | 1993 |
Effect of felodipine on systemic hemodynamics of spontaneous mild-hypertensive aged rats.
Topics: Aging; Animals; Blood Pressure; Cardiac Output; Cerebrovascular Circulation; Felodipine; Female; Hem | 1995 |
Pharmacologic agents on cardiovascular mass, coronary dynamics and collagen in aged spontaneously hypertensive rats.
Topics: Aging; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Body Weight; Calc | 1999 |
A population study of the pharmacokinetics of felodipine.
Topics: Adult; Aged; Aged, 80 and over; Aging; Antihypertensive Agents; Body Weight; Drug Interactions; Felo | 1991 |
Pharmacokinetics of felodipine in patients with liver disease.
Topics: Adult; Aged; Aging; Blood Pressure; Calcium Channel Blockers; Felodipine; Female; Heart Rate; Humans | 1989 |
Influence of age on calcium entry blocking drugs in rat aorta is spasmogen-dependent.
Topics: Aging; Animals; Aorta; Calcium; Calcium Channel Blockers; Diltiazem; Drug Interactions; Felodipine; | 1989 |