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felodipine and Aging

felodipine has been researched along with Aging in 14 studies

Felodipine: A dihydropyridine calcium antagonist with positive inotropic effects. It lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels.
felodipine : The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"The antihypertensive effects of lisinopril 10-20 mg once daily and felodipine (extended release formulation) 5-10 mg once daily were compared in a double-blind, parallel group study of eight weeks duration involving 219 patients with mild to moderate hypertension."9.07Efficacy and tolerability of lisinopril compared with extended release felodipine in patients with essential hypertension. Danish Cooperative Study Group. ( Jensen, HA, 1992)
"To characterize the population dose-response and concentration-response relationships of felodipine and to investigate the influence of patient variables on these relationships."6.68Felodipine population dose-response and concentration-response relationships in patients with essential hypertension. ( Sambol, NC; Wade, JR, 1995)
"The antihypertensive effects of lisinopril 10-20 mg once daily and felodipine (extended release formulation) 5-10 mg once daily were compared in a double-blind, parallel group study of eight weeks duration involving 219 patients with mild to moderate hypertension."5.07Efficacy and tolerability of lisinopril compared with extended release felodipine in patients with essential hypertension. Danish Cooperative Study Group. ( Jensen, HA, 1992)
" This study was designed to determine the effects of aging and AT-1 receptor blockade (losartan 30 mg/kg/day beginning at 8 weeks of age) on NO system in this model."3.71Effects of aging and AT-1 receptor blockade on NO synthase expression and renal function in SHR. ( Kivlighn, S; Ni, ZN; Shahinfar, S; Vaziri, ND; Wang, XQ, 2002)
"Both enalapril and felodipine ameliorated adverse cardiovascular effects of hypertension in the aged SHRs within 12 weeks, as demonstrated by reduced arterial pressure, diminished left ventricular mass, and improved coronary hemodynamics."3.70Pharmacologic agents on cardiovascular mass, coronary dynamics and collagen in aged spontaneously hypertensive rats. ( Frohlich, ED; Susic, D; Varagic, J, 1999)
" Amlodipine did not affect cardiac function in the young, and with chronic dosing decreased the heart rate by 3-5 bpm and the cardiac index by 0."2.72Sympatho-excitatory responses to once-daily dihydropyridines in young versus older hypertensive patients: amlodipine versus felodipine extended release. ( Coletta, E; Leenen, FH; White, R, 2006)
"To characterize the population dose-response and concentration-response relationships of felodipine and to investigate the influence of patient variables on these relationships."2.68Felodipine population dose-response and concentration-response relationships in patients with essential hypertension. ( Sambol, NC; Wade, JR, 1995)
"Felodipine appears to lower blood pressure effectively in the elderly patient with few, generally mild, adverse effects."2.38Efficacy and safety of felodipine, a new dihydropyridine calcium channel blocker, in elderly hypertensive patients. ( DeQuattro, V, 1992)
"A new, once-daily combination tablet containing felodipine and metoprolol has been developed, using extended-release techniques to obtain even plasma concentrations throughout the dosing interval."1.29Design and pharmacokinetics of Logimax, a new extended-release combination tablet of felodipine and metoprolol. ( Abrahamsson, B; Edgar, B; Lidman, K; Wingstrand, K, 1993)
" With increasing age the area under the felodipine plasma concentration vs time curve (AUC), the maximum plasma concentration (Cmax), and the terminal elimination half-life of felodipine increased, while the plasma clearance of felodipine decreased."1.28A population study of the pharmacokinetics of felodipine. ( Blychert, E; Edgar, B; Elmfeldt, D; Hedner, T, 1991)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19902 (14.29)18.7374
1990's10 (71.43)18.2507
2000's2 (14.29)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Vaziri, ND1
Wang, XQ1
Ni, ZN1
Kivlighn, S1
Shahinfar, S1
Leenen, FH1
Coletta, E1
White, R1
Wade, JR1
Sambol, NC1
Hojo, Y1
Ebata, H1
Kawasaki, K1
Tsuruya, Y1
Ikeda, U1
Nishinaga, M1
Natsume, T1
Ishida, H1
Shimada, K1
Abrahamsson, B1
Edgar, B3
Lidman, K1
Wingstrand, K1
Rivas-Cabañero, L1
Rodríguez-Barbero, A1
Macías-Núñez, JF1
López-Novoa, JM1
Susic, D1
Varagic, J1
Frohlich, ED1
Jensen, HA1
DeQuattro, V1
Morgan, TO1
Anderson, A1
Jones, E1
Blychert, E1
Elmfeldt, D1
Hedner, T1
Hosie, J1
Mulder, AW1
Westberg, B1
Regårdh, CG1
Olsson, R1
Kendall, M1
Collste, P1
Shansky, C1
Wanstall, JC1
O'Donnell, SR1

Reviews

1 review available for felodipine and Aging

ArticleYear
Efficacy and safety of felodipine, a new dihydropyridine calcium channel blocker, in elderly hypertensive patients.
    Clinical and experimental hypertension. Part A, Theory and practice, 1992, Volume: 14, Issue:6

    Topics: Aging; Felodipine; Hemodynamics; Humans; Hypertension; Treatment Outcome

1992

Trials

5 trials available for felodipine and Aging

ArticleYear
Sympatho-excitatory responses to once-daily dihydropyridines in young versus older hypertensive patients: amlodipine versus felodipine extended release.
    Journal of hypertension, 2006, Volume: 24, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aging; Amlodipine; Antihypertensive Agents; Blood Pressure; Body Wei

2006
Felodipine population dose-response and concentration-response relationships in patients with essential hypertension.
    Clinical pharmacology and therapeutics, 1995, Volume: 57, Issue:5

    Topics: Adult; Aged; Aging; Algorithms; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Metho

1995
Efficacy and tolerability of lisinopril compared with extended release felodipine in patients with essential hypertension. Danish Cooperative Study Group.
    Clinical and experimental hypertension. Part A, Theory and practice, 1992, Volume: 14, Issue:6

    Topics: Adult; Aged; Aging; Blood Pressure; Delayed-Action Preparations; Dipeptides; Felodipine; Female; Hum

1992
Comparison and interaction of low dose felodipine and enalapril in the treatment of essential hypertension in elderly subjects.
    American journal of hypertension, 1992, Volume: 5, Issue:4 Pt 1

    Topics: Aged; Aging; Blood Pressure; Body Weight; Dose-Response Relationship, Drug; Double-Blind Method; Dru

1992
Felodipine once daily in elderly hypertensives. Binational MC Study Group (United Kingdom and Netherlands).
    Journal of human hypertension, 1991, Volume: 5, Issue:1

    Topics: Aged; Aging; Blood Pressure; Delayed-Action Preparations; Felodipine; Humans; Hypertension

1991

Other Studies

8 other studies available for felodipine and Aging

ArticleYear
Effects of aging and AT-1 receptor blockade on NO synthase expression and renal function in SHR.
    Biochimica et biophysica acta, 2002, Oct-21, Volume: 1592, Issue:2

    Topics: Aging; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pr

2002
Altered levels of erythrocyte calcium-binding proteins in essential hypertensives with genetic predisposition: correlation with ambulatory blood pressure.
    Journal of hypertension, 1994, Volume: 12, Issue:4

    Topics: Aging; Ambulatory Care; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Cytos

1994
Design and pharmacokinetics of Logimax, a new extended-release combination tablet of felodipine and metoprolol.
    Blood pressure. Supplement, 1993, Volume: 1

    Topics: Adult; Aged; Aging; Biological Availability; Delayed-Action Preparations; Drug Combinations; Felodip

1993
Effect of felodipine on systemic hemodynamics of spontaneous mild-hypertensive aged rats.
    Archives of physiology and biochemistry, 1995, Volume: 103, Issue:1

    Topics: Aging; Animals; Blood Pressure; Cardiac Output; Cerebrovascular Circulation; Felodipine; Female; Hem

1995
Pharmacologic agents on cardiovascular mass, coronary dynamics and collagen in aged spontaneously hypertensive rats.
    Journal of hypertension, 1999, Volume: 17, Issue:8

    Topics: Aging; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Body Weight; Calc

1999
A population study of the pharmacokinetics of felodipine.
    British journal of clinical pharmacology, 1991, Volume: 31, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aging; Antihypertensive Agents; Body Weight; Drug Interactions; Felo

1991
Pharmacokinetics of felodipine in patients with liver disease.
    European journal of clinical pharmacology, 1989, Volume: 36, Issue:5

    Topics: Adult; Aged; Aging; Blood Pressure; Calcium Channel Blockers; Felodipine; Female; Heart Rate; Humans

1989
Influence of age on calcium entry blocking drugs in rat aorta is spasmogen-dependent.
    European journal of pharmacology, 1989, Jan-17, Volume: 159, Issue:3

    Topics: Aging; Animals; Aorta; Calcium; Calcium Channel Blockers; Diltiazem; Drug Interactions; Felodipine;

1989