felbamate has been researched along with Status Epilepticus in 7 studies
Felbamate: A PEGylated phenylcarbamate derivative that acts as an antagonist of NMDA RECEPTORS. It is used as an anticonvulsant, primarily for the treatment of SEIZURES in severe refractory EPILEPSY.
felbamate : The bis(carbamate ester) of 2-phenylpropane-1,3-diol. An anticonvulsant, it is used in the treatment of epilepsy.
Status Epilepticus: A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our patient's electrographic status epilepticus of sleep resolved after treatment with felbamate." | 7.81 | Successful Treatment of Electrographic Status Epilepticus of Sleep With Felbamate in a Patient With SLC9A6 Mutation. ( Coorg, R; Weisenberg, JL, 2015) |
| "To examine the seizure-protective properties of fluorofelbamate, a felbamate analog, on acute and chronic seizures in an experimental model of self-sustaining status epilepticus (SSSE)." | 7.71 | Anticonvulsant and antiepileptogenic effects of fluorofelbamate in experimental status epilepticus. ( Mazarati, AM; Sofia, RD; Wasterlain, CG, 2002) |
| "To examine the putative seizure-protective properties of felbamate in an animal model of self-sustaining status epilepticus (SSSE)." | 7.70 | Felbamate in experimental model of status epilepticus. ( Baldwin, RA; Mazarati, AM; Sofia, RD; Wasterain, CG, 2000) |
| "Felbamate was compared with several antiepileptic drugs for protective effects in two rat models of status epilepticus." | 7.68 | Effects of felbamate and other anticonvulsant drugs in two models of status epilepticus in the rat. ( Diamantis, W; Gels, M; Gordon, R; Sofia, RD, 1993) |
| "Our patient's electrographic status epilepticus of sleep resolved after treatment with felbamate." | 3.81 | Successful Treatment of Electrographic Status Epilepticus of Sleep With Felbamate in a Patient With SLC9A6 Mutation. ( Coorg, R; Weisenberg, JL, 2015) |
| "A novel class of 19 carbamates was synthesized, and their anticonvulsant activity was comparatively evaluated in the rat maximal electroshock (MES) and subcutaneous metrazol (scMet) seizure tests and pilocarpine-induced status epilepticus (SE) model." | 3.78 | Syntheses and evaluation of anticonvulsant activity of novel branched alkyl carbamates. ( Bialer, M; Hen, N; Yagen, B, 2012) |
| "To examine the seizure-protective properties of fluorofelbamate, a felbamate analog, on acute and chronic seizures in an experimental model of self-sustaining status epilepticus (SSSE)." | 3.71 | Anticonvulsant and antiepileptogenic effects of fluorofelbamate in experimental status epilepticus. ( Mazarati, AM; Sofia, RD; Wasterlain, CG, 2002) |
| "To examine the putative seizure-protective properties of felbamate in an animal model of self-sustaining status epilepticus (SSSE)." | 3.70 | Felbamate in experimental model of status epilepticus. ( Baldwin, RA; Mazarati, AM; Sofia, RD; Wasterain, CG, 2000) |
| "Felbamate was compared with several antiepileptic drugs for protective effects in two rat models of status epilepticus." | 3.68 | Effects of felbamate and other anticonvulsant drugs in two models of status epilepticus in the rat. ( Diamantis, W; Gels, M; Gordon, R; Sofia, RD, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hen, N | 1 |
| Bialer, M | 1 |
| Yagen, B | 1 |
| Coorg, R | 1 |
| Weisenberg, JL | 1 |
| Mazarati, AM | 2 |
| Sofia, RD | 3 |
| Wasterlain, CG | 1 |
| Hughes, JR | 1 |
| Fuller, T | 1 |
| DeGiorgio, CM | 1 |
| Lopez, JE | 1 |
| Lekht, ZN | 1 |
| Rabinowicz, AL | 1 |
| Gordon, R | 1 |
| Gels, M | 1 |
| Diamantis, W | 1 |
| Baldwin, RA | 1 |
| Wasterain, CG | 1 |
7 other studies available for felbamate and Status Epilepticus
| Article | Year |
|---|---|
Syntheses and evaluation of anticonvulsant activity of novel branched alkyl carbamates.
Topics: Animals; Anticonvulsants; Carbamates; Male; Mice; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawle | 2012 |
Successful Treatment of Electrographic Status Epilepticus of Sleep With Felbamate in a Patient With SLC9A6 Mutation.
Topics: Anticonvulsants; Ataxia; Child; Epilepsy; Felbamate; Genetic Diseases, X-Linked; Humans; Intellectua | 2015 |
Anticonvulsant and antiepileptogenic effects of fluorofelbamate in experimental status epilepticus.
Topics: Animals; Anticonvulsants; Chronic Disease; Electrodes, Implanted; Electroencephalography; Felbamate; | 2002 |
The use of felbamate in patients with periodic lateralized epileptiform discharges (PLEDs).
Topics: Anticonvulsants; Dominance, Cerebral; Dose-Response Relationship, Drug; Drug Therapy, Combination; E | 1995 |
Status epilepticus induced by Felbatol withdrawal.
Topics: Adult; Anticonvulsants; Electroencephalography; Felbamate; Female; Humans; Phenylcarbamates; Propyle | 1995 |
Effects of felbamate and other anticonvulsant drugs in two models of status epilepticus in the rat.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Felbam | 1993 |
Felbamate in experimental model of status epilepticus.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Diazepam; Disease Models, Animal; Dose-Response Relationshi | 2000 |