felbamate has been researched along with Seizures in 46 studies
Felbamate: A PEGylated phenylcarbamate derivative that acts as an antagonist of NMDA RECEPTORS. It is used as an anticonvulsant, primarily for the treatment of SEIZURES in severe refractory EPILEPSY.
felbamate : The bis(carbamate ester) of 2-phenylpropane-1,3-diol. An anticonvulsant, it is used in the treatment of epilepsy.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The antiepileptic drug felbamate has demonstrated efficacy against a variety of seizure types in the pediatric population, particularly seizures associated with Lennox-Gastaut syndrome." | 7.76 | Efficacy of felbamate in the treatment of intractable pediatric epilepsy. ( Chico, MS; Eggener, KA; Hecox, KE; Marcuccilli, CJ; O'Connor, SE; Roell Werner, R; Schwabe, MS; Zupanc, ML, 2010) |
| "Isobolographic profile of interactions between lamotrigine (LTG) and felbamate (FBM), two second-generation antiepileptic drugs, against maximal electroshock (MES)-induced seizures, and neurotoxic adverse effects in the chimney test in mice were determined." | 7.73 | Interaction between lamotrigine and felbamate in the maximal electroshock-induced seizures in mice: an isobolographic analysis. ( Czuczwar, SJ; Luszczki, JJ, 2005) |
| " Anticonvulsant effects were evaluated against seizures induced by both 14 mg/kg of 4-aminopyridine and 110 mg/kg of pentylenetetrazole, and neurotoxic effects were evaluated by the rotarod test." | 7.72 | Synergistic interaction between felbamate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice. ( Armijo, JA; Bravo, J; Cuadrado, A, 2003) |
| " Anticonvulsant effects were evaluated against seizures induced by 14 mg kg(-1) of 4-aminopyridine (4-AP) and by 110 mg kg(-1) of pentylenetetrazole (PTZ), and neurotoxicity by the rotarod test." | 7.72 | Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial? ( Amat, G; Armijo, JA; Cuadrado, A, 2003) |
| " The aim of this study was to evaluate the profile of interactions between FBM and four conventional antiepileptic drugs (AEDs): clonazepam (CZP), ethosuximide (ESM), phenobarbital (PB), and valproate (VPA), in pentylenetetrazole (PTZ)-induced convulsions in mice, a model of myoclonic seizures in humans." | 7.72 | Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ, 2004) |
| "The aim of the study was to assess the efficacy and safety of felbamate (FBM) as add-on therapy in pediatric patients with severe uncontrolled seizures during a 3-year follow-up." | 7.71 | The long-term use of felbamate in children with severe refractory epilepsy. ( Cilio, MR; Kartashov, AI; Vigevano, F, 2001) |
| "Six dogs with partial seizures or partial seizure-like activity were treated with the antiepileptic drug felbamate between 1993 and 1998." | 7.71 | Treatment of partial seizures and seizure-like activity with felbamate in six dogs. ( March, P; Podell, M; Ruehlmann, D, 2001) |
| "The anticonvulsant effects of felbamate alone or in combination with diazepam were investigated against maximal electroshock-, pentylenetetrazol-, isoniazid- and bicuculline-induced seizures in mice." | 7.68 | Interaction of felbamate and diazepam against maximal electroshock seizures and chemoconvulsants in mice. ( Diamantis, W; Gels, M; Gordon, R; Sofia, RD, 1991) |
| "Felbamate was compared with several antiepileptic drugs for protective effects in two rat models of status epilepticus." | 7.68 | Effects of felbamate and other anticonvulsant drugs in two models of status epilepticus in the rat. ( Diamantis, W; Gels, M; Gordon, R; Sofia, RD, 1993) |
| "felbamate appears to be an effective new AED: the most adverse effects occurring during administration of FBM are mild to moderate gastrointestinal (nausea, vomiting and anorexia) and central nervous system (headache, sonnolence, diplopia, dizziness and insomnia) disturbances." | 6.68 | [Felbamate: a long-term study in subjects with refractory epilepsy]. ( De Romanis, F; Sopranzi, N, 1997) |
| "Electroconvulsions were produced by means of an alternating current (ear-clip electrodes, 0." | 5.31 | Low propensity of conventional antiepileptic drugs for interaction with felbamate against maximal electroshock-induced seizures in mice. ( Borowicz, KK; Czuczwar, SJ; Gasior, M; Kleinrok, Z; Stasiuk, G; Teter, J, 2000) |
| "To do so, the maximal electroshock seizure test in mice (an experimental model predicting drug efficacy in the treatment of human generalized tonic-clonic seizures) was employed to (1) quantify changes in the protective efficacy and potency of felbamate produced by adjunct drugs and (2) assess the ability of aminophylline and caffeine to affect protective efficacy afforded by a submaximal protective dose of felbamate against maximal electroshock-induced seizures." | 5.30 | Felbamate demonstrates low propensity for interaction with methylxanthines and Ca2+ channel modulators against experimental seizures in mice. ( Borowicz, K; Czuczwar, SJ; Gasior, M; Kleinrok, Z; Przybyłko, M; Swiader, M; Turski, WA, 1998) |
| "The patient experienced complete seizure control and almost complete return of language skills following the addition of felbamate." | 5.29 | Felbamate in the treatment of acquired epileptic aphasia. ( Glauser, TA; Olberding, LS; Piccirillo, DM; Titanic, MK, 1995) |
| "Since 1994, three new antiepileptic drugs, felbamate, lamotrigene, and gabapentin, have been released for the treatment of epilepsy." | 4.79 | A review of the newer antiepileptic drugs and the ketogenic diet. ( Barron, TF; Hunt, SL, 1997) |
| " In this study, the pentylenetetrazole seizure test (PTZ) was performed to assess the effectiveness of four new ASDs: lamotrigine (LTG), topiramate (TPM), felbamate (FBM), and levetiracetam (LEV) in the subsequent stages of seizures in adult fish." | 4.02 | Effects of new antiseizure drugs on seizure activity and anxiety-like behavior in adult zebrafish. ( Doboszewska, U; Guz, L; Pieróg, M; Poleszak, E; Serefko, A; Socała, K; Szopa, A; Wlaź, P; Wyska, E, 2021) |
| "This single center analysis retrospectively evaluated the safety and efficacy of felbamate in a cohort of children, adolescents, and adults with epilepsy." | 3.83 | Evaluating the safety and efficacy of felbamate in the context of a black box warning: A single center experience. ( Devinsky, O; Friedman, D; Kothare, SV; Shah, YD; Singh, K, 2016) |
| "A novel class of 19 carbamates was synthesized, and their anticonvulsant activity was comparatively evaluated in the rat maximal electroshock (MES) and subcutaneous metrazol (scMet) seizure tests and pilocarpine-induced status epilepticus (SE) model." | 3.78 | Syntheses and evaluation of anticonvulsant activity of novel branched alkyl carbamates. ( Bialer, M; Hen, N; Yagen, B, 2012) |
| "The antiepileptic drug felbamate has demonstrated efficacy against a variety of seizure types in the pediatric population, particularly seizures associated with Lennox-Gastaut syndrome." | 3.76 | Efficacy of felbamate in the treatment of intractable pediatric epilepsy. ( Chico, MS; Eggener, KA; Hecox, KE; Marcuccilli, CJ; O'Connor, SE; Roell Werner, R; Schwabe, MS; Zupanc, ML, 2010) |
| "Isobolographic profile of interactions between lamotrigine (LTG) and felbamate (FBM), two second-generation antiepileptic drugs, against maximal electroshock (MES)-induced seizures, and neurotoxic adverse effects in the chimney test in mice were determined." | 3.73 | Interaction between lamotrigine and felbamate in the maximal electroshock-induced seizures in mice: an isobolographic analysis. ( Czuczwar, SJ; Luszczki, JJ, 2005) |
| " Anticonvulsant effects were evaluated against seizures induced by both 14 mg/kg of 4-aminopyridine and 110 mg/kg of pentylenetetrazole, and neurotoxic effects were evaluated by the rotarod test." | 3.72 | Synergistic interaction between felbamate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice. ( Armijo, JA; Bravo, J; Cuadrado, A, 2003) |
| " Anticonvulsant effects were evaluated against seizures induced by 14 mg kg(-1) of 4-aminopyridine (4-AP) and by 110 mg kg(-1) of pentylenetetrazole (PTZ), and neurotoxicity by the rotarod test." | 3.72 | Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial? ( Amat, G; Armijo, JA; Cuadrado, A, 2003) |
| "We investigated the effect of felbamate, administered singly and in combination with carbamazepine, phenobarbital, phenytoin or clonazepam, on various behavioral and electrographic correlates of seizures in amygdala-kindled rats." | 3.72 | Effect of felbamate and its combinations with conventional antiepileptics in amygdala-kindled rats. ( Borowicz, KK; Czuczwar, SJ; Patsalos, PN; Ratnaraj, N, 2004) |
| " The aim of this study was to evaluate the profile of interactions between FBM and four conventional antiepileptic drugs (AEDs): clonazepam (CZP), ethosuximide (ESM), phenobarbital (PB), and valproate (VPA), in pentylenetetrazole (PTZ)-induced convulsions in mice, a model of myoclonic seizures in humans." | 3.72 | Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ, 2004) |
| "Six dogs with partial seizures or partial seizure-like activity were treated with the antiepileptic drug felbamate between 1993 and 1998." | 3.71 | Treatment of partial seizures and seizure-like activity with felbamate in six dogs. ( March, P; Podell, M; Ruehlmann, D, 2001) |
| "The aim of the study was to assess the efficacy and safety of felbamate (FBM) as add-on therapy in pediatric patients with severe uncontrolled seizures during a 3-year follow-up." | 3.71 | The long-term use of felbamate in children with severe refractory epilepsy. ( Cilio, MR; Kartashov, AI; Vigevano, F, 2001) |
| "Glycine blocked the anticonvulsant effects of felbamate on electroshock- and NMDA-induced seizures in mice." | 3.69 | Selective antagonism of the anticonvulsant effects of felbamate by glycine. ( Barnett, A; Coffin, V; Cohen-Williams, M, 1994) |
| "The effects of three new antiepileptic drugs (felbamate, lamotrigine and gabapentin) on the parameters of seizure initiation and termination in one model of reverberatory seizures in the hippocampal-parahippocampal loop in urethane-anesthetized rats were determined." | 3.69 | Effects of felbamate, gabapentin and lamotrigine on seizure parameters and excitability in the rat hippocampus. ( Stringer, JL; Xiong, ZQ, 1997) |
| "Felbamate was approved in July 1993 for use alone or in combination with other antiepileptic drugs for partial seizures and Lennox-Gastaut syndrome." | 3.69 | Felbamate overdose: a case report and discussion of a new antiepileptic drug. ( Nagel, TR; Schunk, JE, 1995) |
| "The anticonvulsant activity of felbamate against sound-induced seizures was studied in the DBA/2 mouse model." | 3.69 | Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice. ( Aguglia, U; Bertorelli, R; De Sarro, A; De Sarro, G; Ongini, E, 1994) |
| "Felbamate was compared with several antiepileptic drugs for protective effects in two rat models of status epilepticus." | 3.68 | Effects of felbamate and other anticonvulsant drugs in two models of status epilepticus in the rat. ( Diamantis, W; Gels, M; Gordon, R; Sofia, RD, 1993) |
| "The anticonvulsant effects of felbamate alone or in combination with diazepam were investigated against maximal electroshock-, pentylenetetrazol-, isoniazid- and bicuculline-induced seizures in mice." | 3.68 | Interaction of felbamate and diazepam against maximal electroshock seizures and chemoconvulsants in mice. ( Diamantis, W; Gels, M; Gordon, R; Sofia, RD, 1991) |
| "One study claimed an average seizure reduction of 35." | 2.82 | Felbamate add-on therapy for drug-resistant focal epilepsy. ( Bresnahan, R; Dong, J; Geng, J; Martin-McGill, KJ; Ni, H; Shi, LL, 2022) |
| "Dementia and epilepsy have a complicated relationship, thus targeting mitophagy for cure of epileptic dementia makes sense." | 2.82 | The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches. ( Agrawal, M; Dhurandhar, Y; Panda, SP, 2022) |
| "felbamate appears to be an effective new AED: the most adverse effects occurring during administration of FBM are mild to moderate gastrointestinal (nausea, vomiting and anorexia) and central nervous system (headache, sonnolence, diplopia, dizziness and insomnia) disturbances." | 2.68 | [Felbamate: a long-term study in subjects with refractory epilepsy]. ( De Romanis, F; Sopranzi, N, 1997) |
| "Data regarding antiepileptic drug use in RRT are limited and mostly consist of case reports limiting our proposed dosing recommendations." | 2.53 | Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy. ( Bastin, ML; Cook, AM; Oyler, DR; Smetana, KS, 2016) |
| " So the search for more effective drugs with minimal adverse effect profiles will continue." | 2.42 | Adverse effects of new antiepileptic drugs. ( Onat, F; Ozkara, C, 2004) |
| "Successful control of seizures with anticonvulsant drugs reflects a balance in achieving seizure control while minimizing undesirable drug side effects." | 2.40 | Anticonvulsant therapy in small animals. ( Boothe, DM, 1998) |
| "Successful treatment of seizure disorders in small animals requires proper patient assessment, understanding the principles of antiepileptic drug (AED) therapy, designing a strategy for pharmacotherapy, and plans for emergency treatment." | 2.40 | Antiepileptic drug therapy. ( Podell, M, 1998) |
| " Chronic administration of bupropion significantly potentiates the protective activity of lamotrigine, topiramate, and felbamate against maximal electroshock-induced seizures." | 1.37 | Low dose of bupropion significantly enhances the anticonvulsant activity of felbamate, lamotrigine and topiramate in mice. ( Bańka, K; Barczyński, B; Buszewicz, G; Mądro, R; Mróz, T; Tutaj, K; Tutka, P; Wielosz, M; Łuszczki, JJ, 2011) |
| "LEV in combination with FBM was associated with pharmacodynamic supraadditivity in the MES test." | 1.34 | Levetiracetam and felbamate interact both pharmacodynamically and pharmacokinetically: an isobolographic analysis in the mouse maximal electroshock model. ( Andres-Mach, MM; Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2007) |
| " However, these conclusions are confounded by the fact that LCZ is associated with significant pharmacokinetic interactions." | 1.33 | Pharmacodynamic and pharmacokinetic interaction studies of loreclezole with felbamate, lamotrigine, topiramate, and oxcarbazepine in the mouse maximal electroshock seizure model. ( Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2005) |
| "Electroconvulsions were produced by means of an alternating current (ear-clip electrodes, 0." | 1.31 | Low propensity of conventional antiepileptic drugs for interaction with felbamate against maximal electroshock-induced seizures in mice. ( Borowicz, KK; Czuczwar, SJ; Gasior, M; Kleinrok, Z; Stasiuk, G; Teter, J, 2000) |
| "When information became available on aplastic anemia and hepatotoxicity associated with felbamate, all patients were advised to taper their felbamate dosage over approximately 2 weeks." | 1.30 | Increased seizure frequency associated with felbamate withdrawal in adults. ( Privitera, M; Shukla, R; Welty, TE, 1998) |
| "To do so, the maximal electroshock seizure test in mice (an experimental model predicting drug efficacy in the treatment of human generalized tonic-clonic seizures) was employed to (1) quantify changes in the protective efficacy and potency of felbamate produced by adjunct drugs and (2) assess the ability of aminophylline and caffeine to affect protective efficacy afforded by a submaximal protective dose of felbamate against maximal electroshock-induced seizures." | 1.30 | Felbamate demonstrates low propensity for interaction with methylxanthines and Ca2+ channel modulators against experimental seizures in mice. ( Borowicz, K; Czuczwar, SJ; Gasior, M; Kleinrok, Z; Przybyłko, M; Swiader, M; Turski, WA, 1998) |
| "The patient experienced complete seizure control and almost complete return of language skills following the addition of felbamate." | 1.29 | Felbamate in the treatment of acquired epileptic aphasia. ( Glauser, TA; Olberding, LS; Piccirillo, DM; Titanic, MK, 1995) |
| "Seven patients with refractory seizure disorders and neuropsychiatric symptoms believed secondary to felbamate are presented." | 1.29 | Neuropsychiatric side effects related to treatment with felbamate. ( Brillman, J; Cavalier, J; Cress, K; Duffy, JD; McConnell, H; Snyder, PJ; Valeriano, J; Weilburg, J, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 23 (50.00) | 18.2507 |
| 2000's | 14 (30.43) | 29.6817 |
| 2010's | 6 (13.04) | 24.3611 |
| 2020's | 3 (6.52) | 2.80 |
| Authors | Studies |
|---|---|
| Hen, N | 1 |
| Bialer, M | 2 |
| Yagen, B | 1 |
| Mawasi, H | 1 |
| Bibi, D | 1 |
| Panda, SP | 1 |
| Dhurandhar, Y | 1 |
| Agrawal, M | 1 |
| Shi, LL | 1 |
| Bresnahan, R | 1 |
| Martin-McGill, KJ | 1 |
| Dong, J | 1 |
| Ni, H | 1 |
| Geng, J | 1 |
| Pieróg, M | 1 |
| Socała, K | 1 |
| Doboszewska, U | 1 |
| Wyska, E | 1 |
| Guz, L | 1 |
| Szopa, A | 1 |
| Serefko, A | 1 |
| Poleszak, E | 1 |
| Wlaź, P | 1 |
| Shah, YD | 1 |
| Singh, K | 1 |
| Friedman, D | 1 |
| Devinsky, O | 1 |
| Kothare, SV | 1 |
| Smetana, KS | 1 |
| Cook, AM | 1 |
| Bastin, ML | 1 |
| Oyler, DR | 1 |
| White, JR | 1 |
| Leppik, IE | 2 |
| Beattie, JL | 1 |
| Walczak, TS | 1 |
| Tran, TA | 1 |
| Rarick, JO | 1 |
| Vaher, P | 1 |
| Zupanc, ML | 1 |
| Roell Werner, R | 1 |
| Schwabe, MS | 1 |
| O'Connor, SE | 1 |
| Marcuccilli, CJ | 1 |
| Hecox, KE | 1 |
| Chico, MS | 1 |
| Eggener, KA | 1 |
| Barczyński, B | 1 |
| Buszewicz, G | 1 |
| Łuszczki, JJ | 1 |
| Bańka, K | 1 |
| Tutaj, K | 1 |
| Mróz, T | 1 |
| Wielosz, M | 1 |
| Mądro, R | 1 |
| Tutka, P | 1 |
| Cuadrado, A | 2 |
| Bravo, J | 1 |
| Armijo, JA | 2 |
| Amat, G | 1 |
| Borowicz, KK | 3 |
| Ratnaraj, N | 3 |
| Patsalos, PN | 3 |
| Czuczwar, SJ | 9 |
| Onat, F | 1 |
| Ozkara, C | 1 |
| Luszczki, JJ | 6 |
| Andres-Mach, MM | 1 |
| Danysz, W | 1 |
| De Sarro, G | 1 |
| Ongini, E | 1 |
| Bertorelli, R | 1 |
| Aguglia, U | 1 |
| De Sarro, A | 1 |
| Glauser, TA | 1 |
| Olberding, LS | 1 |
| Titanic, MK | 1 |
| Piccirillo, DM | 1 |
| Kerrick, JM | 1 |
| Kelley, BJ | 1 |
| Maister, BH | 1 |
| Graves, NM | 1 |
| Coffin, V | 1 |
| Cohen-Williams, M | 1 |
| Barnett, A | 1 |
| Sofia, RD | 2 |
| Gordon, R | 2 |
| Gels, M | 2 |
| Diamantis, W | 2 |
| Snodgrass, SR | 1 |
| Nagel, TR | 1 |
| Schunk, JE | 1 |
| Bourgeois, B | 1 |
| McConnell, H | 1 |
| Snyder, PJ | 1 |
| Duffy, JD | 1 |
| Weilburg, J | 1 |
| Valeriano, J | 1 |
| Brillman, J | 1 |
| Cress, K | 1 |
| Cavalier, J | 1 |
| Kelley, MT | 1 |
| Walson, PD | 1 |
| Cox, S | 1 |
| Dusci, LJ | 1 |
| Nyberg, AG | 1 |
| Waara, L | 1 |
| Karlsson, B | 1 |
| Cassel, G | 1 |
| Xiong, ZQ | 1 |
| Stringer, JL | 1 |
| Barron, TF | 1 |
| Hunt, SL | 1 |
| De Romanis, F | 1 |
| Sopranzi, N | 1 |
| Sunder, TR | 1 |
| Blaszczak, P | 1 |
| Turski, WA | 2 |
| Boothe, DM | 1 |
| Welty, TE | 1 |
| Privitera, M | 1 |
| Shukla, R | 1 |
| Haugvicová, R | 1 |
| Kubová, H | 1 |
| Mares, P | 1 |
| Gasior, M | 2 |
| Swiader, M | 1 |
| Przybyłko, M | 1 |
| Borowicz, K | 1 |
| Kleinrok, Z | 2 |
| Podell, M | 2 |
| Stasiuk, G | 1 |
| Teter, J | 1 |
| Ruehlmann, D | 1 |
| March, P | 1 |
| Cilio, MR | 1 |
| Kartashov, AI | 1 |
| Vigevano, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Study of Pharmacokinetics of Levetiracetam in Patients Undergoing Intermittent Hemodialysis[NCT04511676] | 12 participants (Actual) | Observational | 2018-11-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for felbamate and Seizures
| Article | Year |
|---|---|
The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches.
Topics: Anticonvulsants; Carbamazepine; Dementia; Epilepsy; Felbamate; Gabapentin; Humans; Inflammasomes; La | 2022 |
Felbamate add-on therapy for drug-resistant focal epilepsy.
Topics: Anticonvulsants; Drug Resistant Epilepsy; Drug Therapy, Combination; Drug-Related Side Effects and A | 2022 |
Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy.
Topics: Acetamides; Acute Kidney Injury; Amines; Anticonvulsants; Carbamates; Critical Illness; Cyclohexanec | 2016 |
Adverse effects of new antiepileptic drugs.
Topics: Adult; Anticonvulsants; Child; Clinical Trials as Topic; Epilepsy; Felbamate; Humans; Phenylcarbamat | 2004 |
Clinical use of drugs useful in the treatment of atonic seizures.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Epilepsy, Genera | 1995 |
A review of the newer antiepileptic drugs and the ketogenic diet.
Topics: Acetates; Age Factors; Amines; Anticonvulsants; Child; Child, Preschool; Cyclohexanecarboxylic Acids | 1997 |
Meeting the challenge of epilepsy in persons with multiple handicaps.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Comorbidity; Developmental Disabilities | 1997 |
Anticonvulsant therapy in small animals.
Topics: Acetates; Amines; Animals; Anticonvulsants; Bromides; Clonazepam; Clorazepate Dipotassium; Cyclohexa | 1998 |
Antiepileptic drug therapy.
Topics: Acetates; Amines; Animals; Anticonvulsants; Bromides; Cat Diseases; Cats; Cyclohexanecarboxylic Acid | 1998 |
1 trial available for felbamate and Seizures
| Article | Year |
|---|---|
[Felbamate: a long-term study in subjects with refractory epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsies, Partial; Epilepsy; | 1997 |
36 other studies available for felbamate and Seizures
| Article | Year |
|---|---|
Syntheses and evaluation of anticonvulsant activity of novel branched alkyl carbamates.
Topics: Animals; Anticonvulsants; Carbamates; Male; Mice; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawle | 2012 |
Design and comparative anticonvulsant activity assessment of CNS-active alkyl-carbamoyl imidazole derivatives.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Carbamates; Electroshock; Imidazoles; Male; Mice; Rat | 2016 |
Effects of new antiseizure drugs on seizure activity and anxiety-like behavior in adult zebrafish.
Topics: Age Factors; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Dose-Response Relationship, Dru | 2021 |
Evaluating the safety and efficacy of felbamate in the context of a black box warning: A single center experience.
Topics: Adolescent; Adult; Age of Onset; Anemia, Aplastic; Anticonvulsants; Child; Cohort Studies; Drug Labe | 2016 |
Long-term use of felbamate: clinical outcomes and effect of age and concomitant antiepileptic drug use on its clearance.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Child; Dose-Response Relationship, Drug; Drug | 2009 |
Efficacy of felbamate in the treatment of intractable pediatric epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Epilepsy; Felbamate; F | 2010 |
Low dose of bupropion significantly enhances the anticonvulsant activity of felbamate, lamotrigine and topiramate in mice.
Topics: Animals; Anticonvulsants; Brain; Bupropion; Dopamine Uptake Inhibitors; Dose-Response Relationship, | 2011 |
Synergistic interaction between felbamate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Drug Synergism; | 2003 |
Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial?
Topics: 4-Aminopyridine; Analysis of Variance; Animals; Brain; Chromatography, Liquid; Disease Models, Anima | 2003 |
Effect of felbamate and its combinations with conventional antiepileptics in amygdala-kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Drug Interactions; Drug Therapy, Combination; Felbamate; Kindlin | 2004 |
Preclinical profile of combinations of some second-generation antiepileptic drugs: an isobolographic analysis.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Evaluation, Preclinical; Drug | 2004 |
Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Clonazepam; Disease Models, Animal; Drug Interactions; D | 2004 |
Interaction between lamotrigine and felbamate in the maximal electroshock-induced seizures in mice: an isobolographic analysis.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Electroshoc | 2005 |
Pharmacodynamic and pharmacokinetic interaction studies of loreclezole with felbamate, lamotrigine, topiramate, and oxcarbazepine in the mouse maximal electroshock seizure model.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Disease Models, Animal; Drug Interactions | 2005 |
Levetiracetam and felbamate interact both pharmacodynamically and pharmacokinetically: an isobolographic analysis in the mouse maximal electroshock model.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Chromatography, High Pressure Liquid; Disease Mod | 2007 |
Interactions of MRZ 2/576 with felbamate, lamotrigine, oxcarbazepine and topiramate in the mouse maximal electroshock-induced seizure model.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; D | 2008 |
Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvuls | 1994 |
Felbamate in the treatment of acquired epileptic aphasia.
Topics: Anticonvulsants; Aphasia; Child; Electroencephalography; Epilepsy; Felbamate; Humans; Language; Male | 1995 |
Involuntary movement disorders associated with felbamate.
Topics: Adolescent; Age of Onset; Akathisia, Drug-Induced; Anticonvulsants; Electroencephalography; Felbamat | 1995 |
Selective antagonism of the anticonvulsant effects of felbamate by glycine.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Felbamate; Glycine; Male; | 1994 |
Felbamate.
Topics: Adult; Animals; Anticonvulsants; Child; Clinical Trials as Topic; Drug Interactions; Felbamate; Huma | 1993 |
Effects of felbamate and other anticonvulsant drugs in two models of status epilepticus in the rat.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Felbam | 1993 |
Felbamate therapy in the Lennox-Gastaut syndrome.
Topics: Anticonvulsants; Epilepsy, Generalized; Felbamate; Humans; Phenylcarbamates; Propylene Glycols; Seiz | 1993 |
Felbamate overdose: a case report and discussion of a new antiepileptic drug.
Topics: Adolescent; Anticonvulsants; Drug Overdose; Felbamate; Female; Humans; Phenylcarbamates; Propylene G | 1995 |
Neuropsychiatric side effects related to treatment with felbamate.
Topics: Adult; Anticonvulsants; Drug Interactions; Felbamate; Female; Humans; Male; Middle Aged; Phenylcarba | 1996 |
Population pharmacokinetics of felbamate in children.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Drug Interactions; Drug Monitoring; Felbamate; Hu | 1997 |
Effect of pretreatment with felbamate on toxicity of soman in mice.
Topics: Animals; Cholinesterase Inhibitors; Cholinesterases; Convulsants; Drug Interactions; Felbamate; Fema | 1997 |
Effects of felbamate, gabapentin and lamotrigine on seizure parameters and excitability in the rat hippocampus.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose-Response Relationship, | 1997 |
Excitatory amino acid antagonists alleviate convulsive and toxic properties of lindane in mice.
Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Felbamate; Hexachlorocyclohexane; I | 1998 |
Increased seizure frequency associated with felbamate withdrawal in adults.
Topics: Acetates; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Felbamate; Gabapentin; gamma- | 1998 |
Qualitative changes of anticonvulsant action of felbamate during development in rats.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Fe | 1998 |
Felbamate demonstrates low propensity for interaction with methylxanthines and Ca2+ channel modulators against experimental seizures in mice.
Topics: Aminophylline; Animals; Anticonvulsants; Caffeine; Calcium Channels; Electric Stimulation; Felbamate | 1998 |
Low propensity of conventional antiepileptic drugs for interaction with felbamate against maximal electroshock-induced seizures in mice.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Drug Interactions; Electroshock; Felbamate; Fem | 2000 |
Treatment of partial seizures and seizure-like activity with felbamate in six dogs.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Felbamate; Female; Male; Phenylcarbamates; Propylene G | 2001 |
The long-term use of felbamate in children with severe refractory epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy; Felbamate; Female; Follow-Up | 2001 |
Interaction of felbamate and diazepam against maximal electroshock seizures and chemoconvulsants in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Diazepam; Drug Interactions; Electroshock; Felbamate; GABA-A | 1991 |