felbamate has been researched along with Liver Failure in 4 studies
Felbamate: A PEGylated phenylcarbamate derivative that acts as an antagonist of NMDA RECEPTORS. It is used as an anticonvulsant, primarily for the treatment of SEIZURES in severe refractory EPILEPSY.
felbamate : The bis(carbamate ester) of 2-phenylpropane-1,3-diol. An anticonvulsant, it is used in the treatment of epilepsy.
Liver Failure: Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Felbamate has been approved for refractory partial seizures since the early nineties." | 5.42 | The rise and fall of felbamate as a treatment for partial epilepsy--aplastic anemia and hepatic failure to blame? ( Billa, G; Chudasama, H; Goswami, S; Rane, J; Shah, R; Thakkar, K, 2015) |
| "Felbamate is a novel anti-epileptic drug (AED) which has recently been associated with reports of aplastic anaemia and liver failure." | 5.08 | Felbamate as add-on therapy. ( Duncan, JS; Li, LM; Moriarty, J; Nashef, L; Sander, JW, 1996) |
| "Since 1993, eight new antiepileptic drugs (AEDs) have become available in the United States for the treatment of epilepsy: felbamate, gabapentin, lamotrigine, topiramate, tiagabine, levetiracetam, oxcarbazepine, and zonisamide." | 4.81 | Some common issues in the use of antiepileptic drugs. ( Asconapé, JJ, 2002) |
| "Felbamate has been approved for refractory partial seizures since the early nineties." | 1.42 | The rise and fall of felbamate as a treatment for partial epilepsy--aplastic anemia and hepatic failure to blame? ( Billa, G; Chudasama, H; Goswami, S; Rane, J; Shah, R; Thakkar, K, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thakkar, K | 1 |
| Billa, G | 1 |
| Rane, J | 1 |
| Chudasama, H | 1 |
| Goswami, S | 1 |
| Shah, R | 1 |
| Asconapé, JJ | 1 |
| Li, LM | 1 |
| Nashef, L | 1 |
| Moriarty, J | 1 |
| Duncan, JS | 1 |
| Sander, JW | 1 |
| Pellock, JM | 1 |
| Brodie, MJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Normalization of Sodium on Bone Markers in Patients With Epilepsy. A Randomized Single-blinded Placebo-controlled Trial.[NCT03371199] | 21 participants (Actual) | Interventional | 2017-12-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for felbamate and Liver Failure
| Article | Year |
|---|---|
Some common issues in the use of antiepileptic drugs.
Topics: Adolescent; Adult; Aged; Anemia, Aplastic; Anticonvulsants; Body Weight; Cognition Disorders; Drug E | 2002 |
1 trial available for felbamate and Liver Failure
| Article | Year |
|---|---|
Felbamate as add-on therapy.
Topics: Adult; Anemia, Aplastic; Anticonvulsants; Epilepsy; Felbamate; Follow-Up Studies; Humans; Liver Fail | 1996 |
2 other studies available for felbamate and Liver Failure
| Article | Year |
|---|---|
The rise and fall of felbamate as a treatment for partial epilepsy--aplastic anemia and hepatic failure to blame?
Topics: Anemia, Aplastic; Anticonvulsants; Drug Resistant Epilepsy; Epilepsies, Partial; Felbamate; Humans; | 2015 |
Felbamate: 1997 update.
Topics: Anemia, Aplastic; Anticonvulsants; Drug Approval; Epilepsy; Felbamate; Humans; Liver Failure; Phenyl | 1997 |