felbamate has been researched along with Epilepsy, Tonic-Clonic in 4 studies
Felbamate: A PEGylated phenylcarbamate derivative that acts as an antagonist of NMDA RECEPTORS. It is used as an anticonvulsant, primarily for the treatment of SEIZURES in severe refractory EPILEPSY.
felbamate : The bis(carbamate ester) of 2-phenylpropane-1,3-diol. An anticonvulsant, it is used in the treatment of epilepsy.
Epilepsy, Tonic-Clonic: A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Felbamate dosage was titrated to approximately 50 mg/kg/d over three weeks." | 1.29 | Potential pharmacokinetic interaction between felbamate and phenobarbital. ( Gidal, BE; Zupanc, ML, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gidal, BE | 1 |
| Zupanc, ML | 1 |
| Sachdeo, RC | 1 |
| O'Neil, MG | 1 |
| Perdun, CS | 1 |
| Wilson, MB | 1 |
| McGown, ST | 1 |
| Patel, S | 1 |
| French, JA | 1 |
1 review available for felbamate and Epilepsy, Tonic-Clonic
| Article | Year |
|---|---|
The role of new antiepileptic drugs.
Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsies, Partial; Epilepsy; Epi | 2001 |
3 other studies available for felbamate and Epilepsy, Tonic-Clonic
| Article | Year |
|---|---|
Potential pharmacokinetic interaction between felbamate and phenobarbital.
Topics: Adult; Anticonvulsants; Drug Interactions; Epilepsy, Tonic-Clonic; Felbamate; Humans; Male; Phenobar | 1994 |
Felbamate.
Topics: Anticonvulsants; Epilepsy, Tonic-Clonic; Felbamate; Humans; Phenylcarbamates; Propylene Glycols | 1993 |
Felbamate-associated fatal acute hepatic necrosis.
Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Epilepsy, Tonic-Clonic; Fatal Outcome; Felb | 1996 |