felbamate has been researched along with Brain Ischemia in 5 studies
Felbamate: A PEGylated phenylcarbamate derivative that acts as an antagonist of NMDA RECEPTORS. It is used as an anticonvulsant, primarily for the treatment of SEIZURES in severe refractory EPILEPSY.
felbamate : The bis(carbamate ester) of 2-phenylpropane-1,3-diol. An anticonvulsant, it is used in the treatment of epilepsy.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Since most treatment of human cerebral ischemia will have to be delivered after the insult, we investigated the neuroprotective potency of post hoc felbamate in rat pups with bilateral carotid ligations exposed to an atmosphere of 6." | 5.29 | Posthypoxic treatment with felbamate is neuroprotective in a rat model of hypoxia-ischemia. ( Adams, LM; Hattori, H; Schwartz, PH; Sofia, RD; Wasterlain, CG; Wichmann, JK, 1993) |
| "The neuroprotective effects of felbamate were tested in a model of incomplete cerebral ischemia and hypoxia in 7-day-old rat pups." | 3.68 | Felbamate reduces hypoxic-ischemic brain damage in vivo. ( Adams, LM; Hattori, H; Schwartz, PH; Wasterlain, CG, 1992) |
| "Since most treatment of human cerebral ischemia will have to be delivered after the insult, we investigated the neuroprotective potency of post hoc felbamate in rat pups with bilateral carotid ligations exposed to an atmosphere of 6." | 1.29 | Posthypoxic treatment with felbamate is neuroprotective in a rat model of hypoxia-ischemia. ( Adams, LM; Hattori, H; Schwartz, PH; Sofia, RD; Wasterlain, CG; Wichmann, JK, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, CX | 1 |
| Shuaib, A | 1 |
| Wasterlain, CG | 3 |
| Adams, LM | 3 |
| Schwartz, PH | 2 |
| Hattori, H | 2 |
| Sofia, RD | 2 |
| Wichmann, JK | 2 |
| Arcadi, FA | 1 |
| Lo Presti, R | 1 |
| Di Bella, P | 1 |
| Sessa, E | 1 |
| Imperatore, C | 1 |
| Salemi, M | 1 |
| Costa, G | 1 |
| Bramanti, P | 1 |
1 review available for felbamate and Brain Ischemia
| Article | Year |
|---|---|
NMDA/NR2B selective antagonists in the treatment of ischemic brain injury.
Topics: Animals; Brain; Brain Ischemia; Conotoxins; Drug Design; Excitatory Amino Acid Antagonists; Felbamat | 2005 |
4 other studies available for felbamate and Brain Ischemia
| Article | Year |
|---|---|
Posthypoxic treatment with felbamate is neuroprotective in a rat model of hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Body Temperature; Brain; Brain Ischemia; Disease Models, Animal; Felbamat | 1993 |
Felbamate protects CA1 neurons from apoptosis in a gerbil model of global ischemia.
Topics: Animals; Anticonvulsants; Apoptosis; Brain Ischemia; Cell Death; Cell Nucleus; Cell Survival; Cytopl | 1996 |
Changes in somatosensory evoked potentials following forebrain ischemia in the gerbils: effects of felbamate.
Topics: Animals; Brain Ischemia; Dose-Response Relationship, Drug; Evoked Potentials, Somatosensory; Felbama | 1999 |
Felbamate reduces hypoxic-ischemic brain damage in vivo.
Topics: Animals; Anticonvulsants; Behavior, Animal; Body Temperature; Brain Ischemia; Felbamate; Female; Hip | 1992 |