Page last updated: 2024-10-26

felbamate and Abdominal Epilepsy

felbamate has been researched along with Abdominal Epilepsy in 31 studies

Felbamate: A PEGylated phenylcarbamate derivative that acts as an antagonist of NMDA RECEPTORS. It is used as an anticonvulsant, primarily for the treatment of SEIZURES in severe refractory EPILEPSY.
felbamate : The bis(carbamate ester) of 2-phenylpropane-1,3-diol. An anticonvulsant, it is used in the treatment of epilepsy.

Research Excerpts

ExcerptRelevanceReference
"Felbamate (FBM, Felbatol/Taloxa), a new antiepileptic drug (AED), was tested in a placebo-controlled add-on design in 73 patients with therapy refractory Lennox-Gastaut syndrome."9.07Felbamate in the treatment of Lennox-Gastaut syndrome. ( Jensen, PK, 1994)
"felbamate appears to be an effective new AED: the most adverse effects occurring during administration of FBM are mild to moderate gastrointestinal (nausea, vomiting and anorexia) and central nervous system (headache, sonnolence, diplopia, dizziness and insomnia) disturbances."6.68[Felbamate: a long-term study in subjects with refractory epilepsy]. ( De Romanis, F; Sopranzi, N, 1997)
"Felbamate (FBM) is an effective and safe novel antiepileptic drug (AED) for add-on treatment in adults with refractory partial seizures as shown in three pivotal controlled trials."6.38Felbamate: successful development of a new compound for the treatment of epilepsy. ( Schmidt, D, 1993)
"Felbamate has been approved for refractory partial seizures since the early nineties."5.42The rise and fall of felbamate as a treatment for partial epilepsy--aplastic anemia and hepatic failure to blame? ( Billa, G; Chudasama, H; Goswami, S; Rane, J; Shah, R; Thakkar, K, 2015)
"Felbamate (FBM, Felbatol/Taloxa), a new antiepileptic drug (AED), was tested in a placebo-controlled add-on design in 73 patients with therapy refractory Lennox-Gastaut syndrome."5.07Felbamate in the treatment of Lennox-Gastaut syndrome. ( Jensen, PK, 1994)
"Felbamate is a second-generation antiepileptic drug that can be used as add-on therapy to standard antiepileptic drugs."2.82Felbamate add-on therapy for drug-resistant focal epilepsy. ( Bresnahan, R; Dong, J; Geng, J; Martin-McGill, KJ; Ni, H; Shi, LL, 2022)
"felbamate appears to be an effective new AED: the most adverse effects occurring during administration of FBM are mild to moderate gastrointestinal (nausea, vomiting and anorexia) and central nervous system (headache, sonnolence, diplopia, dizziness and insomnia) disturbances."2.68[Felbamate: a long-term study in subjects with refractory epilepsy]. ( De Romanis, F; Sopranzi, N, 1997)
"Felbamate (FBM) is a new antiepileptic drug (AED) that has been tested in open and controlled studies in patients with therapy-refractory partial-onset seizures."2.67Felbamate in the treatment of refractory partial-onset seizures. ( Jensen, PK, 1993)
"Felbamate was statistically superior to placebo in seizure reduction, percent seizure reduction, and truncated percent seizure reduction."2.67Felbamate for partial seizures: results of a controlled clinical trial. ( Bertram, E; Cereghino, JJ; Dreifuss, FE; Drury, I; Graves, NM; Jacobs, MP; Leppik, IE; Pledger, GW; Santilli, N; Tsay, JY, 1991)
" Another reason why the efficacy of FBM cannot yet be fully assessed is that in all the studies the FBM dosage was limited to a maximum of 3,600 mg/day or 45 mg/kg/day."2.39Felbamate in the treatment of partial-onset seizures. ( Bourgeois, BF, 1994)
" GBP is also active in this population, but only the 1,800 mg/day dosage was significantly better than placebo with respect to percent responders."2.39Clinical efficacy of new antiepileptic drugs in refractory partial epilepsy: experience in the United States with three novel drugs. ( French, JA, 1996)
"Felbamate (FBM) is an effective and safe novel antiepileptic drug (AED) for add-on treatment in adults with refractory partial seizures as shown in three pivotal controlled trials."2.38Felbamate: successful development of a new compound for the treatment of epilepsy. ( Schmidt, D, 1993)
"Felbamate has been approved for refractory partial seizures since the early nineties."1.42The rise and fall of felbamate as a treatment for partial epilepsy--aplastic anemia and hepatic failure to blame? ( Billa, G; Chudasama, H; Goswami, S; Rane, J; Shah, R; Thakkar, K, 2015)
"Anorexia and insomnia were reported in 20% and 16% of the patients, respectively."1.29Efficacy of felbamate in therapy for partial epilepsy in children. ( Anderson, J; Carmant, L; Holmes, GL; Mikati, MA; Rifai, N; Sawyer, S, 1994)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's22 (70.97)18.2507
2000's4 (12.90)29.6817
2010's4 (12.90)24.3611
2020's1 (3.23)2.80

Authors

AuthorsStudies
Shi, LL4
Bresnahan, R1
Martin-McGill, KJ1
Dong, J4
Ni, H4
Geng, J4
Wu, T3
Thakkar, K1
Billa, G1
Rane, J1
Chudasama, H1
Goswami, S1
Shah, R1
Héberlé, C1
Berquin, P1
Larnicol, N1
Wallois, F1
Brodie, MJ1
Pellock, JM1
Devinsky, O2
Faught, RE1
Wilder, BJ1
Kanner, AM1
Kamin, M2
Kramer, LD3
Rosenberg, A3
Vazquez, B1
Luciano, D1
Luer, MS1
Jensen, PK2
Bourgeois, BF1
Carmant, L1
Holmes, GL1
Sawyer, S1
Rifai, N1
Anderson, J1
Mikati, MA1
Graves, NM2
Schmidt, D1
Faught, E1
Sachdeo, RC1
Remler, MP1
Chayasirisobhon, S1
Iragui-Madoz, VJ1
Ramsay, RE1
Sutula, TP1
Kanner, A1
Harner, RN1
Kuzniecky, R1
Bourgeois, B1
Leppik, IE3
Sackellares, JC1
Laxer, K1
Lesser, R1
Messenheimer, JA1
Wilner, AN1
French, JA2
De Romanis, F1
Sopranzi, N1
Elger, CE1
Bauer, J1
Scherrmann, J1
Widman, G1
Canger, R1
Vignoli, A1
Bonardi, R1
Guidolin, L1
White, HS1
Contin, M1
Riva, R1
Albani, F1
Baruzzi, AA1
Ebert, U1
Reissmüller, E1
Löscher, W1
Kmieć, T1
Jóźwiak, S1
Kuczyński, D1
Karkowska, B1
Bachański, M1
Sachdeo, R1
Sachdeo, S1
Dreifuss, FE1
Pledger, GW1
Santilli, N1
Drury, I1
Tsay, JY1
Jacobs, MP1
Bertram, E1
Cereghino, JJ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Verapamil as Adjunctive Seizure Therapy for Children and Young Adults With Dravet Syndrome[NCT01607073]Phase 22 participants (Actual)Interventional2012-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Number of Absence Seizures From Week 8 (Baseline) to Week 12

The secondary outcome measure is the change in number of absence seizures from Week 8 (Baseline) to Week 12 (NCT01607073)
Timeframe: Week 8 to Week 12

InterventionAbscence seizures (Number)
Week 8 Baseline165
Week 12 Verapamil 4mg/kg/Day101

Change in Number of General Tonic-clonic Seizures From Week 8 (Baseline) Visit to Week 12 Visit

The primary study endpoint is the change in number of seizures from baseline. Since we only had one participant finish the study, the endpoint was changed to Week 12 visit. Participants were on verapamil for 4 weeks at Week 12. (NCT01607073)
Timeframe: Week 8 (baseline) to Week 12

InterventionGeneral tonic-clonic seizures (Number)
Week 8 Baseline39
Week 12 Verapamil 4mg/kg/Day14

Change in Number of Myoclonic Seizures From Week 8 (Baseline) to Week 12

The secondary outcome is the change in number of myoclonic seizures between baseline Week 8 visit and Week 12 visit. (NCT01607073)
Timeframe: Week 8 (baseline) to Week 12

InterventionMyoclonic seizures (Number)
Week 8 Baseline116
Week 12 Verapamil 4mg/kg/Day175

Reviews

13 reviews available for felbamate and Abdominal Epilepsy

ArticleYear
Felbamate add-on therapy for drug-resistant focal epilepsy.
    The Cochrane database of systematic reviews, 2022, 08-01, Volume: 8

    Topics: Anticonvulsants; Drug Resistant Epilepsy; Drug Therapy, Combination; Drug-Related Side Effects and A

2022
Felbamate as an add-on therapy for refractory partial epilepsy.
    The Cochrane database of systematic reviews, 2017, 07-18, Volume: 7

    Topics: Anticonvulsants; Drug Resistance; Epilepsies, Partial; Felbamate; Humans; Phenylcarbamates; Propylen

2017
Felbamate as an add-on therapy for refractory epilepsy.
    The Cochrane database of systematic reviews, 2014, Jul-18, Issue:7

    Topics: Anticonvulsants; Epilepsies, Partial; Felbamate; Humans; Phenylcarbamates; Propylene Glycols; Random

2014
Felbamate as an add-on therapy for refractory epilepsy.
    The Cochrane database of systematic reviews, 2011, Jan-19, Issue:1

    Topics: Anticonvulsants; Epilepsies, Partial; Felbamate; Humans; Phenylcarbamates; Propylene Glycols; Random

2011
New antiepileptic drugs for children: felbamate, gabapentin, lamotrigine, and vigabatrin.
    Journal of child neurology, 1994, Volume: 9 Suppl 1

    Topics: Acetates; Adult; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Drug Approval; Epileps

1994
Felbamate in the treatment of partial-onset seizures.
    Epilepsia, 1994, Volume: 35 Suppl 5

    Topics: Adult; Anticonvulsants; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Met

1994
Felbamate.
    The Annals of pharmacotherapy, 1993, Volume: 27, Issue:9

    Topics: Adult; Anticonvulsants; Child; Child, Preschool; Clinical Trials as Topic; Drug Interactions; Epilep

1993
Felbamate: successful development of a new compound for the treatment of epilepsy.
    Epilepsia, 1993, Volume: 34 Suppl 7

    Topics: Adult; Anticonvulsants; Child; Clinical Trials as Topic; Drug Administration Schedule; Drug Therapy,

1993
Clinical efficacy of new antiepileptic drugs in refractory partial epilepsy: experience in the United States with three novel drugs.
    Epilepsia, 1996, Volume: 37 Suppl 2

    Topics: Acetates; Adolescent; Adult; Aged; Amines; Anticonvulsants; Controlled Clinical Trials as Topic; Cyc

1996
Aggravation of focal epileptic seizures by antiepileptic drugs.
    Epilepsia, 1998, Volume: 39 Suppl 3

    Topics: Acetates; Acute Disease; Adult; Amines; Anticonvulsants; Clinical Trials as Topic; Cyclohexanecarbox

1998
Role of new and established antiepileptic drugs.
    Epilepsia, 1998, Volume: 39 Suppl 5

    Topics: Animals; Anticonvulsants; Clinical Trials as Topic; Drug Interactions; Epilepsies, Partial; Epilepsy

1998
Comparative anticonvulsant and mechanistic profile of the established and newer antiepileptic drugs.
    Epilepsia, 1999, Volume: 40 Suppl 5

    Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Epilepsies, Partial; Felbamate; Fru

1999
The role of new antiepileptic drugs.
    The American journal of managed care, 2001, Volume: 7, Issue:7 Suppl

    Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsies, Partial; Epilepsy; Epi

2001

Trials

12 trials available for felbamate and Abdominal Epilepsy

ArticleYear
Efficacy of felbamate monotherapy in patients undergoing presurgical evaluation of partial seizures.
    Epilepsy research, 1995, Volume: 20, Issue:3

    Topics: Adult; Aged; Anticonvulsants; Double-Blind Method; Epilepsies, Partial; Evaluation Studies as Topic;

1995
Felbamate in the treatment of Lennox-Gastaut syndrome.
    Epilepsia, 1994, Volume: 35 Suppl 5

    Topics: Adult; Anticonvulsants; Child; Drugs, Investigational; Epilepsies, Partial; Epilepsy; Felbamate; Fol

1994
Felbamate in the treatment of refractory partial-onset seizures.
    Epilepsia, 1993, Volume: 34 Suppl 7

    Topics: Adult; Anticonvulsants; Child; Double-Blind Method; Drug Therapy, Combination; Epilepsies, Partial;

1993
Felbamate monotherapy for partial-onset seizures: an active-control trial.
    Neurology, 1993, Volume: 43, Issue:4

    Topics: Adolescent; Adult; Aged; Alanine Transaminase; Anticonvulsants; Aspartate Aminotransferases; Double-

1993
Felbamate: a double-blind controlled trial in patients undergoing presurgical evaluation of partial seizures.
    Neurology, 1993, Volume: 43, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Double-Blind Method; Epilepsies, Partial; Felbamate; Female; Hum

1993
Efficacy of felbamate monotherapy.
    Annals of neurology, 1993, Volume: 33, Issue:6

    Topics: Anticonvulsants; Epilepsies, Partial; Felbamate; Humans; Phenylcarbamates; Propylene Glycols; Resear

1993
[Felbamate: a long-term study in subjects with refractory epilepsy].
    La Clinica terapeutica, 1997, Volume: 148, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsies, Partial; Epilepsy;

1997
Felbamate in refractory partial epilepsy.
    Epilepsy research, 1999, Volume: 34, Issue:1

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Drug Resistance; Drug Therapy, Combination; Epileps

1999
Effect of felbamate on clobazam and its metabolite kinetics in patients with epilepsy.
    Therapeutic drug monitoring, 1999, Volume: 21, Issue:6

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Chil

1999
[Gabitril as an additive drug in therapy of intractable epileptic seizures in children].
    Neurologia i neurochirurgia polska, 2000, Volume: 34 Suppl 7

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Therapy, Combi

2000
Felbamate monotherapy: controlled trial in patients with partial onset seizures.
    Annals of neurology, 1992, Volume: 32, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Double-Blind Method; Epilepsies, Partial; Felbamate; Female; Hum

1992
Felbamate for partial seizures: results of a controlled clinical trial.
    Neurology, 1991, Volume: 41, Issue:11

    Topics: Adult; Anticonvulsants; Carbamazepine; Double-Blind Method; Drug Therapy, Combination; Epilepsies, P

1991

Other Studies

6 other studies available for felbamate and Abdominal Epilepsy

ArticleYear
The rise and fall of felbamate as a treatment for partial epilepsy--aplastic anemia and hepatic failure to blame?
    Expert review of neurotherapeutics, 2015, Volume: 15, Issue:12

    Topics: Anemia, Aplastic; Anticonvulsants; Drug Resistant Epilepsy; Epilepsies, Partial; Felbamate; Humans;

2015
Vagus nerve stimulation in a case of epilepsy with CSWSS: respiratory side effects during sleep.
    Epilepsia, 2002, Volume: 43, Issue:10

    Topics: Age Factors; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Child; Clobazam; Combined Modali

2002
Taming the brain storms: felbamate updated.
    Lancet (London, England), 1995, Oct-07, Volume: 346, Issue:8980

    Topics: Anemia, Aplastic; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Approval; Drug Monit

1995
Criteria for use of felbamate in adult, adolescent, and child inpatients and outpatients.
    American journal of hospital pharmacy, 1994, Jul-01, Volume: 51, Issue:13

    Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsies, Parti

1994
Efficacy of felbamate in therapy for partial epilepsy in children.
    The Journal of pediatrics, 1994, Volume: 125, Issue:3

    Topics: Adolescent; Age Factors; Anorexia; Anticonvulsants; Child; Child, Preschool; Drug Combinations; Drug

1994
The new antiepileptic drugs lamotrigine and felbamate are effective in phenytoin-resistant kindled rats.
    Neuropharmacology, 2000, Jul-24, Volume: 39, Issue:10

    Topics: Amygdala; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Resistance; Electric Stim

2000