febantel has been researched along with Strongyloidiasis* in 2 studies
2 other study(ies) available for febantel and Strongyloidiasis
Article | Year |
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[2-(Guanidino)-anilides and related compounds. Synthesis and anthelmintic effect. 3. Anthelmintics].
Anilides bearing a guanidino, thioallophanato, isothioallophanato or amidino group in the ortho position were synthesised (6) for investigations of their anthelmintic effects, and tested against sheep trichostrongylides. The most active anilides are those containing a 5-alkylthio, 5-alkylsulphinyl (alkyl = C3H7, C4H9), 5-phenylthio, 5-phenylsulphinyl or 4-phenylsulphonyloxy group, and a guanidino group substituted at both nitrogen atoms by a methoxycarbonyl group. The most active anthelmintic anilides are the form-, propion-, butyr- and methoxy-acetanilides (e.g. 60, 61, 66, 95, 100, 110). Of the guanidines unsubstituted at N' and N", the 2-guanidino-5-phenylthio-2-methoxyacetanilide (123) and the 2-guanidino-5-phenylsulphinyl-2-methoxyacetanilide (152) were more active than parbendazole. From the class of bismethoxycarbonylguanidines (6 alpha), which are also the most interesting products in terms of stability, febantel (110, Rintal) has been introduced into veterinary practice for the treatment of nematode infections in horses, cattle, sheep and swine. Topics: Aniline Compounds; Animals; Anthelmintics; Chemical Phenomena; Chemistry; Female; Guanidines; Haemonchiasis; Hookworm Infections; Nippostrongylus; Rats; Rats, Inbred Strains; Sheep; Strongyloidiasis; Trichostrongyloidiasis | 1984 |
A re-assessment of the efficacy of febantel (Rintal) and fenbendazole (Panacur) against Strongyloides papillosus in sheep and goats.
An efficacy evaluation using febantel and fenbendazole was carried out against Strongyloides papillosus in sheep and goats in the Grootfontein area of South West Africa/Namibia. Three groups with five sheep and three goats in each group were artificially infested with this species. When the worms had reached the adult stage one group was treated with febantel, the other group with fenbendazole and the third group left as controls. Both anthelmintics were dosed at 5 mg/kg. All animals were sacrificed one week after treatment and total worm-counts carried out. Both anthelmintics were found to be highly effective. Topics: Acetanilides; Animals; Anthelmintics; Benzimidazoles; Drug Evaluation, Preclinical; Female; Fenbendazole; Goats; Guanidines; Male; Sheep; Strongyloides; Strongyloidiasis | 1980 |