febantel has been researched along with Fetal-Death* in 1 studies
1 other study(ies) available for febantel and Fetal-Death
Article | Year |
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[Metabolism-embryotoxicity relationship of febantel in the rat and the sheep].
The metabolism of febantel has been investigated in the rat and the sheep. The general pathway seems to be similar in both species: ten urinary metabolites are the result of cyclisation, oxidation and/or hydrolysis process. Using synthetic samples, the embryotoxic study of all individual metabolites has been performed in the rat. Unchanged febantel and two other metabolites are responsible for teratogenic effects. A four steps toxogenic pathway is described which finally leads to the ultimate known teratogen: methyl (5-(phenylsulfinyl)-1H-benzimidazole-2-yl) carbamate. Metabolic similarities with other anthelmintics and residual consequences are discussed. Topics: Abnormalities, Drug-Induced; Animals; Anthelmintics; Chemical Phenomena; Chemistry; Female; Fetal Death; Guanidines; Pregnancy; Rats; Rats, Inbred Strains; Rodent Diseases; Sheep | 1982 |