febantel and Fetal-Death

febantel has been researched along with Fetal-Death* in 1 studies

Other Studies

1 other study(ies) available for febantel and Fetal-Death

Article	Year
[Metabolism-embryotoxicity relationship of febantel in the rat and the sheep]. Annales de recherches veterinaires. Annals of veterinary research, 1982, Volume: 13, Issue:2 The metabolism of febantel has been investigated in the rat and the sheep. The general pathway seems to be similar in both species: ten urinary metabolites are the result of cyclisation, oxidation and/or hydrolysis process. Using synthetic samples, the embryotoxic study of all individual metabolites has been performed in the rat. Unchanged febantel and two other metabolites are responsible for teratogenic effects. A four steps toxogenic pathway is described which finally leads to the ultimate known teratogen: methyl (5-(phenylsulfinyl)-1H-benzimidazole-2-yl) carbamate. Metabolic similarities with other anthelmintics and residual consequences are discussed. Topics: Abnormalities, Drug-Induced; Animals; Anthelmintics; Chemical Phenomena; Chemistry; Female; Fetal Death; Guanidines; Pregnancy; Rats; Rats, Inbred Strains; Rodent Diseases; Sheep	1982

Article

Year

[Metabolism-embryotoxicity relationship of febantel in the rat and the sheep].

Annales de recherches veterinaires. Annals of veterinary research, 1982, Volume: 13, Issue:2

The metabolism of febantel has been investigated in the rat and the sheep. The general pathway seems to be similar in both species: ten urinary metabolites are the result of cyclisation, oxidation and/or hydrolysis process. Using synthetic samples, the embryotoxic study of all individual metabolites has been performed in the rat. Unchanged febantel and two other metabolites are responsible for teratogenic effects. A four steps toxogenic pathway is described which finally leads to the ultimate known teratogen: methyl (5-(phenylsulfinyl)-1H-benzimidazole-2-yl) carbamate. Metabolic similarities with other anthelmintics and residual consequences are discussed.

Topics: Abnormalities, Drug-Induced; Animals; Anthelmintics; Chemical Phenomena; Chemistry; Female; Fetal Death; Guanidines; Pregnancy; Rats; Rats, Inbred Strains; Rodent Diseases; Sheep

1982