febantel and Cat-Diseases

This study evaluated the effect of two combination products containing febantel, pyrantel, and praziquantel (FPP) for the treatment of Giardia species in experimentally infected kittens. In experiment 1, five kittens were administered the United States (US) formulation of FPP at doses of 37.8 mg/kg, 7.56 mg/kg, and 7.56 mg/kg, respectively, PO, q24h, for 5 days and four kittens remained as controls. In experiment 2, five kittens were administered the European formulation of FPP at the doses of 12.5 mg/kg, 12 mg/kg, and 4.16 mg/kg, respectively, PO, q24h, for 5 days and four kittens remained as controls. In experiment 3, six kittens were administered the US formulation of FPP at 56.5 mg/kg, 11.3 mg/kg, 11.3 mg/kg, respectively, PO, q24h, for 5 days and five kittens remained as controls. Thirteen days after treatment, kittens testing negative for Giardia species cysts were administered 20 mg/kg methylprednisolone acetate, IM, weekly for a maximum of two injections. Feces were analyzed for Giardia species cysts using a direct immunofluorescence test. After experiment 3, four of the six treated kittens, but no control kittens, remained negative for Giardia species after the administration of methylprednisolone acetate.

Topics: Aging; Animals; Anthelmintics; Cat Diseases; Cats; Drug Combinations; Female; Giardiasis; Guanidines; Male; Praziquantel; Pyrantel; Tablets; Treatment Outcome

A paste formulation of 3.4% febantel and 0.34% praziquantel was given in soft food at a rate of 0.29 g/kg of body weight, once daily for 3 days to dogs and cats. Eleven of 12 dogs were naturally infected with Ancylostoma caninum, 10 with Trichuris vulpis, 2 with Toxocara canis, 5 with Taenia sp, and 3 with Dirofilaria immitis. Ten of 11 cats were naturally infected with Toxocara cati, 2 with Ancylostoma tubaeforme, 3 with Taenia sp, 5 with Capillaria aerophila, and 1 with Paragonimus kellicotti. Efficacy was 100% for the removal of A caninum, T canis, and Taenia sp and 99.9% in clearance of T vulpis in dogs, and 100% in removal of A tubaeforme, T cati, and Taenia sp in cats. In dogs, Dirofilaria appeared unaffected, and in cats, there was no apparent effect on Capillaria or on Paragonimus. The paste formulation given in soft food was well tolerated and without observable adverse effects.

Topics: Animals; Anthelmintics; Cat Diseases; Cats; Cestode Infections; Dog Diseases; Dogs; Drug Combinations; Female; Guanidines; Intestinal Diseases, Parasitic; Isoquinolines; Male; Nematode Infections; Ointments; Praziquantel