fasudil has been researched along with Weight Gain in 2 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
Weight Gain: Increase in BODY WEIGHT over existing weight.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Treatment with the Rho-kinase inhibitor fasudil attenuated weight gain and insulin resistance in mice on a HFD." | 3.77 | Rho and Rho-kinase activity in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch. ( Fujimura, K; Hara, Y; Hasegawa, K; Hayashi, K; Homma, K; Hosoya, K; Itoh, H; Minakuchi, H; Nakayama, K; Saito, M; Tanabe, Y; Tatematsu, S; Tokuyama, H; Wakino, S; Washida, N; Yoshioka, K, 2011) |
| "Fasudil was administered by oral gavage from post-natal day 3 to 21 at a concentration of 30 mg/kg twice daily." | 1.38 | Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy. ( Anderson, CL; Bowerman, M; Boyer, JG; Kothary, R; Murray, LM, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hara, Y | 1 |
| Wakino, S | 1 |
| Tanabe, Y | 1 |
| Saito, M | 1 |
| Tokuyama, H | 1 |
| Washida, N | 1 |
| Tatematsu, S | 1 |
| Yoshioka, K | 1 |
| Homma, K | 1 |
| Hasegawa, K | 1 |
| Minakuchi, H | 1 |
| Fujimura, K | 1 |
| Hosoya, K | 1 |
| Hayashi, K | 1 |
| Nakayama, K | 1 |
| Itoh, H | 1 |
| Bowerman, M | 1 |
| Murray, LM | 1 |
| Boyer, JG | 1 |
| Anderson, CL | 1 |
| Kothary, R | 1 |
2 other studies available for fasudil and Weight Gain
| Article | Year |
|---|---|
Rho and Rho-kinase activity in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adipocytes; Animals; Diet, Fat-Restricted; Insulin Re | 2011 |
Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anterior Horn Cells; Disease Models, Animal; | 2012 |