fasudil has been researched along with Wallerian Degeneration in 2 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
Wallerian Degeneration: Degeneration of distal aspects of a nerve axon following injury to the cell body or proximal portion of the axon. The process is characterized by fragmentation of the axon and its MYELIN SHEATH.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Injection of 10 microM and 100 microM Y-27632 induced extension of the optic axons beyond the crush site, with the latter dosage giving stronger regeneration." | 1.35 | Differential effects of two ROCK inhibitors, Fasudil and Y-27632, on optic nerve regeneration in adult cats. ( Ichikawa, M; Sagawa, H; Saito, K; Tokita, Y; Watanabe, M; Yoshida, J, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, X | 1 |
| Minohara, M | 1 |
| Kikuchi, H | 1 |
| Ishizu, T | 1 |
| Tanaka, M | 1 |
| Piao, H | 1 |
| Osoegawa, M | 1 |
| Ohyagi, Y | 1 |
| Shimokawa, H | 1 |
| Kira, J | 1 |
| Ichikawa, M | 1 |
| Yoshida, J | 1 |
| Saito, K | 1 |
| Sagawa, H | 1 |
| Tokita, Y | 1 |
| Watanabe, M | 1 |
2 other studies available for fasudil and Wallerian Degeneration
| Article | Year |
|---|---|
The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Central Nervous System; Chemotaxis, Leukocyt | 2006 |
Differential effects of two ROCK inhibitors, Fasudil and Y-27632, on optic nerve regeneration in adult cats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Axons; Cats; Cells, Cultured; Dose-R | 2008 |