Page last updated: 2024-10-28

fasudil and Subarachnoid Hemorrhage

fasudil has been researched along with Subarachnoid Hemorrhage in 44 studies

fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.

Subarachnoid Hemorrhage: Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.

Research Excerpts

ExcerptRelevanceReference
"Fasudil is believed to be at least equally effective as nimodipine for the prevention of cerebral vasospasm and subsequent ischemic injury in patients undergoing surgery for subarachnoid hemorrhage (SAH)."9.15Efficacy and safety of fasudil in patients with subarachnoid hemorrhage: final results of a randomized trial of fasudil versus nimodipine. ( Guo, J; Mao, Y; Ren, Z; Wang, R; Wang, S; Xu, B; Zhang, X; Zhang, Y; Zhao, J; Zhao, K; Zhou, D; Zhou, L, 2011)
" This randomized open trial with nimodipine as the control included 72 patients who underwent subarachnoid hemorrhage surgery for ruptured cerebral aneurysm of Hunt and Hess grades I to IV."9.12Effect of fasudil hydrochloride, a protein kinase inhibitor, on cerebral vasospasm and delayed cerebral ischemic symptoms after aneurysmal subarachnoid hemorrhage. ( Guo, J; Ren, Z; Wang, R; Wang, S; Xu, B; Zhao, J; Zhou, D; Zhou, L, 2006)
"This study aims to systematically assess the efficacy and safety of fasudil for the treatment of aneurysmal subarachnoid hemorrhage (ASH)."9.01Efficacy of fasudil for the treatment of aneurysmal subarachnoid hemorrhage: A systematic review protocol of randomized controlled trial. ( Chang, XF; Shen, RB; Song, GF; Wang, HY; Yang, FY; Yang, HW, 2019)
" To date, the only Rho-kinase inhibitor employed clinically in humans is fasudil, which has been used for the prevention of cerebral vasospasm and subsequent ischemic injury after surgery for subarachnoid hemorrhage (SAH)."8.90Pleiotropic effects of the rho-kinase inhibitor fasudil after subarachnoid hemorrhage: a review of preclinical and clinical studies. ( Asano, T; Ikegaki, I; Kawasaki, K; Satoh, S; Shibuya, M, 2014)
"Fasudil greatly reduces the occurrence of CVS and cerebral infarction in SAH patients, significantly improves the clinical outcomes of the patients (as assessed by the Glasgow Outcome Scale)."8.88Systematic assessment and meta-analysis of the efficacy and safety of fasudil in the treatment of cerebral vasospasm in patients with subarachnoid hemorrhage. ( He, GH; Liu, GJ; Liu, Y; Luo, GJ; Wang, XL; Wang, YF; Wang, ZJ; Xu, LL; Zeng, YJ, 2012)
"The incidence of convulsion and associated factors were retrospectively analyzed in 23 patients with symptomatic cerebral vasospasm following subarachnoid hemorrhage (SAH) who underwent a total of 31 intra-arterial infusion of fasudil hydrochloride (IAFH) procedures in 49 vessels."7.76Convulsion during intra-arterial infusion of fasudil hydrochloride for the treatment of cerebral vasospasm following subarachnoid hemorrhage. ( Enomoto, Y; Iwama, T; Yamada, K; Yoshimura, S, 2010)
"The cerebral circulatory dynamics were evaluated before and after intra-arterial administration of fasudil hydrochloride in 20 patients with angiographic vasospasm after subarachnoid hemorrhage (SAH)."7.73Intra-arterial administration of fasudil hydrochloride for vasospasm following subarachnoid hemorrhage - analysis of time-density curve with digital subtraction angiography. ( Hayashi, M; Iwabuchi, S; Samejima, H; Ueda, M; Uehara, H; Yokouchi, T, 2006)
"The authors report a case of convulsion during intra-arterial selective infusion of fasudil hydrochloride (FSD) for treatment of vasospasm following subarachnoid hemorrhage (SAH)."7.72[A case of convulsion during selective intra-arterial infusion of fasudil hydrochloride for treatment of vasospasm following subarachnoid hemorrhage]. ( Date, I; Nakashimia, H; Ohmoto, T; Ono, S; Sasahara, W; Sugiu, K; Tokunaga, K, 2004)
"To investigate the safety and efficacy of liposomal fasudil in a sustained-release form for the prevention of cerebral vasospasm after subarachnoid hemorrhage (SAH)."7.71Efficacy of intrathecal liposomal fasudil for experimental cerebral vasospasm after subarachnoid hemorrhage. ( Ishida, T; Kiwada, H; Meguro, T; Takanashi, Y; Yamamoto, I; Zhang, JH, 2001)
" Since September 1995, the combination of fasudil hydrochloride and ozagrel sodium, an inhibitor of thromboxane A2 synthesis, has been used to treat 60 patients at risk of cerebral vasospasm after aneurysmal subarachnoid hemorrhage."7.70Combination therapy of fasudil hydrochloride and ozagrel sodium for cerebral vasospasm following aneurysmal subarachnoid hemorrhage. ( Abe, M; Fukuyama, K; Mineta, T; Nakashima, S; Shimokawa, S; Tabuchi, K, 1998)
"Fasudil were added in 18 (38."5.91Real-world data of clazosentan in combination therapy for aneurysmal subarachnoid hemorrhage: a multicenter retrospective cohort study. ( Araki, Y; Asai, T; Fukui, T; Koketsu, N; Muraoka, S; Nishizawa, T; Ota, S; Saito, R; Shimato, S, 2023)
" The occurrence of adverse events, occurrence of low density areas associated with vasospasm on computed tomography, absence of symptomatic vasospasm, and poor clinical outcomes associated with vasospasm were compared between the fasudil and fasudil plus ozagrel groups."5.35Safety and efficacy of fasudil monotherapy and fasudil-ozagrel combination therapy in patients with subarachnoid hemorrhage: sub-analysis of the post-marketing surveillance study. ( Satoh, S; Seto, M; Shibuya, M; Sugiyama, H; Suzuki, Y; Takakura, K, 2008)
"This new approach for cerebral vasospasm may have significant potential for use in the clinical setting."5.31Intrathecal application with liposome-entrapped Fasudil for cerebral vasospasm following subarachnoid hemorrhage in rats. ( Allen, TM; Ishida, T; Kirchmeier, MJ; Meguro, T; Takanashi, Y; Zhang, JH, 2001)
"since October 1999, nicardipine pellets (NP) have been used to prevent vasospasm in patients with subarachnoid hemorrhage (SAH)."5.15Clinical trial of nicardipine prolonged-release implants for preventing cerebral vasospasm: multicenter cooperative study in Tokyo. ( Kasuya, H, 2011)
"Fasudil is believed to be at least equally effective as nimodipine for the prevention of cerebral vasospasm and subsequent ischemic injury in patients undergoing surgery for subarachnoid hemorrhage (SAH)."5.15Efficacy and safety of fasudil in patients with subarachnoid hemorrhage: final results of a randomized trial of fasudil versus nimodipine. ( Guo, J; Mao, Y; Ren, Z; Wang, R; Wang, S; Xu, B; Zhang, X; Zhang, Y; Zhao, J; Zhao, K; Zhou, D; Zhou, L, 2011)
" This randomized open trial with nimodipine as the control included 72 patients who underwent subarachnoid hemorrhage surgery for ruptured cerebral aneurysm of Hunt and Hess grades I to IV."5.12Effect of fasudil hydrochloride, a protein kinase inhibitor, on cerebral vasospasm and delayed cerebral ischemic symptoms after aneurysmal subarachnoid hemorrhage. ( Guo, J; Ren, Z; Wang, R; Wang, S; Xu, B; Zhao, J; Zhou, D; Zhou, L, 2006)
"This study aims to systematically assess the efficacy and safety of fasudil for the treatment of aneurysmal subarachnoid hemorrhage (ASH)."5.01Efficacy of fasudil for the treatment of aneurysmal subarachnoid hemorrhage: A systematic review protocol of randomized controlled trial. ( Chang, XF; Shen, RB; Song, GF; Wang, HY; Yang, FY; Yang, HW, 2019)
" To date, the only Rho-kinase inhibitor employed clinically in humans is fasudil, which has been used for the prevention of cerebral vasospasm and subsequent ischemic injury after surgery for subarachnoid hemorrhage (SAH)."4.90Pleiotropic effects of the rho-kinase inhibitor fasudil after subarachnoid hemorrhage: a review of preclinical and clinical studies. ( Asano, T; Ikegaki, I; Kawasaki, K; Satoh, S; Shibuya, M, 2014)
"Fasudil greatly reduces the occurrence of CVS and cerebral infarction in SAH patients, significantly improves the clinical outcomes of the patients (as assessed by the Glasgow Outcome Scale)."4.88Systematic assessment and meta-analysis of the efficacy and safety of fasudil in the treatment of cerebral vasospasm in patients with subarachnoid hemorrhage. ( He, GH; Liu, GJ; Liu, Y; Luo, GJ; Wang, XL; Wang, YF; Wang, ZJ; Xu, LL; Zeng, YJ, 2012)
"We envisage the efficacy and safety of intra-arterial infusion of fasudil hydrochloride (IAF) for symptomatic vasospasm (SVS) after subarachnoid hemorrhage (SAH)."3.79Beneficial effect of selective intra-arterial infusion of fasudil hydrochloride as a treatment of symptomatic vasospasm following SAH. ( Chang, HS; Fujisawa, N; Hosono, A; Indo, M; Matsui, T; Nakamura, T; Okano, A; Oya, S; Suzuki, Y; Tsuchiya, T, 2013)
"The incidence of convulsion and associated factors were retrospectively analyzed in 23 patients with symptomatic cerebral vasospasm following subarachnoid hemorrhage (SAH) who underwent a total of 31 intra-arterial infusion of fasudil hydrochloride (IAFH) procedures in 49 vessels."3.76Convulsion during intra-arterial infusion of fasudil hydrochloride for the treatment of cerebral vasospasm following subarachnoid hemorrhage. ( Enomoto, Y; Iwama, T; Yamada, K; Yoshimura, S, 2010)
"Using CT perfusion studies we evaluated changes in the cerebral circulation before and after the intravenous administration of fasudil 60 mg in 8 patients 7 to 14 days after a subarachnoid hemorrhage."3.73[Cerebral circulation dynamics following fasudil intravenous infusion: a CT perfusion study]. ( Ono, K; Shirotani, T; Yamana, D; Yuba, K, 2005)
"The cerebral circulatory dynamics were evaluated before and after intra-arterial administration of fasudil hydrochloride in 20 patients with angiographic vasospasm after subarachnoid hemorrhage (SAH)."3.73Intra-arterial administration of fasudil hydrochloride for vasospasm following subarachnoid hemorrhage - analysis of time-density curve with digital subtraction angiography. ( Hayashi, M; Iwabuchi, S; Samejima, H; Ueda, M; Uehara, H; Yokouchi, T, 2006)
"The authors report a case of convulsion during intra-arterial selective infusion of fasudil hydrochloride (FSD) for treatment of vasospasm following subarachnoid hemorrhage (SAH)."3.72[A case of convulsion during selective intra-arterial infusion of fasudil hydrochloride for treatment of vasospasm following subarachnoid hemorrhage]. ( Date, I; Nakashimia, H; Ohmoto, T; Ono, S; Sasahara, W; Sugiu, K; Tokunaga, K, 2004)
"To investigate the safety and efficacy of liposomal fasudil in a sustained-release form for the prevention of cerebral vasospasm after subarachnoid hemorrhage (SAH)."3.71Efficacy of intrathecal liposomal fasudil for experimental cerebral vasospasm after subarachnoid hemorrhage. ( Ishida, T; Kiwada, H; Meguro, T; Takanashi, Y; Yamamoto, I; Zhang, JH, 2001)
" Since September 1995, the combination of fasudil hydrochloride and ozagrel sodium, an inhibitor of thromboxane A2 synthesis, has been used to treat 60 patients at risk of cerebral vasospasm after aneurysmal subarachnoid hemorrhage."3.70Combination therapy of fasudil hydrochloride and ozagrel sodium for cerebral vasospasm following aneurysmal subarachnoid hemorrhage. ( Abe, M; Fukuyama, K; Mineta, T; Nakashima, S; Shimokawa, S; Tabuchi, K, 1998)
"The chapter on subarachnoid hemorrhage includes new and revised recommendations for diagnosis, treatment selection, and management of vasospasm."2.53[Japanese Guidelines for the Management of Stroke 2015: overview of the chapter on Subarachnoid Hemorrhage]. ( Ishihara, H; Suzuki, M, 2016)
"Fasudil were added in 18 (38."1.91Real-world data of clazosentan in combination therapy for aneurysmal subarachnoid hemorrhage: a multicenter retrospective cohort study. ( Araki, Y; Asai, T; Fukui, T; Koketsu, N; Muraoka, S; Nishizawa, T; Ota, S; Saito, R; Shimato, S, 2023)
" The occurrence of adverse events, occurrence of low density areas associated with vasospasm on computed tomography, absence of symptomatic vasospasm, and poor clinical outcomes associated with vasospasm were compared between the fasudil and fasudil plus ozagrel groups."1.35Safety and efficacy of fasudil monotherapy and fasudil-ozagrel combination therapy in patients with subarachnoid hemorrhage: sub-analysis of the post-marketing surveillance study. ( Satoh, S; Seto, M; Shibuya, M; Sugiyama, H; Suzuki, Y; Takakura, K, 2008)
"Fasudil hydrochloride was administered via the internal carotid artery without selective microcatheterization, at a concentration and speed of 30 mg/20 ml/10-15 min, using a total dose of 30-60 mg."1.33[Intra-arterial administration of fasudil hydrochloride: duration of action]. ( Matsushita, Y; Ono, K; Shirotani, T; Takahara, T; Wada, K; Yamana, D; Yuba, K, 2005)
"Delayed cerebral vasospasm after subarachnoid hemorrhage (SAH) may be due, in part, to altered regulation of arterial smooth muscle contraction."1.33Activation of Rho-associated kinase during augmented contraction of the basilar artery to serotonin after subarachnoid hemorrhage. ( Faraci, FM; Heistad, DD; Watanabe, Y, 2005)
"Cerebral vasospasm is a potentially fatal consequence of aneurysmal subarachnoid hemorrhage and influences the prognosis of the patient."1.31Thin and thick filament regulation of contractility in experimental cerebral vasospasm. ( Butler, WE; Kim, I; Leinweber, BD; Morgalla, M; Morgan, KG; Peterson, JW; Sasaki, Y; Seto, M, 2000)
"This new approach for cerebral vasospasm may have significant potential for use in the clinical setting."1.31Intrathecal application with liposome-entrapped Fasudil for cerebral vasospasm following subarachnoid hemorrhage in rats. ( Allen, TM; Ishida, T; Kirchmeier, MJ; Meguro, T; Takanashi, Y; Zhang, JH, 2001)

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-19902 (4.55)18.7374
1990's8 (18.18)18.2507
2000's16 (36.36)29.6817
2010's16 (36.36)24.3611
2020's2 (4.55)2.80

Authors

AuthorsStudies
Muraoka, S1
Asai, T1
Fukui, T1
Ota, S1
Shimato, S1
Koketsu, N1
Nishizawa, T1
Araki, Y1
Saito, R1
Ohta, T1
Matsumoto, S1
Fukumitsu, R1
Imamura, H1
Adachi, H1
Hara, Y1
Hosoda, K1
Kimura, H3
Kuwayama, K1
Mizowaki, T1
Motooka, Y1
Miyata, S1
Shinoda, N1
Ueno, Y1
Yamaura, I1
Yoshida, Y1
Sakai, C1
Sakai, N1
Wang, HY1
Song, GF1
Yang, HW1
Chang, XF1
Shen, RB1
Yang, FY1
Fan, R1
Enkhjargal, B1
Camara, R1
Yan, F1
Gong, L1
Tang, J1
Chen, Y1
Zhang, JH4
Naraoka, M2
Munakata, A1
Matsuda, N1
Shimamura, N2
Ohkuma, H2
Satoh, S6
Ikegaki, I4
Kawasaki, K1
Asano, T5
Shibuya, M10
Iwabuchi, S3
Hayashi, M3
Yokouchi, T3
Sato, K2
Nakayama, H2
Harashina, J2
Iwama, J1
Ishii, M1
Hiramoto, Y1
Hirai, N1
Hirata, Y2
Saito, N2
Ito, K2
Aoki, K2
Saito, A1
Inoue, M1
Kon, H1
Imaruoka, S1
Basaki, K1
Midorikawa, H1
Sasaki, T3
Nishijima, M1
Egea-Guerrero, JJ1
Murillo-Cabezas, F1
Muñoz-Sánchez, MÁ1
Vilches-Arenas, A1
Porras-González, C1
Castellano, A1
Ureña, J1
González-Montelongo, Mdel C1
Ishihara, H1
Suzuki, M1
Suzuki, Y10
Sugiyama, H1
Seto, M2
Takakura, K4
Nakano, T1
Ogasawara, Y1
Takeda, T1
Enomoto, Y1
Yoshimura, S1
Yamada, K1
Iwama, T1
Pierot, L1
Aggour, M1
Moret, J1
Kasuya, H1
Akahata, M1
Ishihara, M1
Yamanaka, K1
Nakajima, S1
Yamasaki, M1
Liu, GJ1
Wang, ZJ1
Wang, YF1
Xu, LL1
Wang, XL1
Liu, Y1
Luo, GJ1
He, GH1
Zeng, YJ1
Zhao, J2
Zhou, D2
Guo, J2
Ren, Z2
Zhou, L2
Wang, S2
Zhang, Y1
Xu, B3
Zhao, K1
Wang, R2
Mao, Y1
Zhang, X1
Nakamura, T1
Matsui, T1
Hosono, A1
Okano, A1
Fujisawa, N1
Tsuchiya, T1
Indo, M1
Oya, S1
Chang, HS1
Sasahara, W1
Ono, S1
Tokunaga, K1
Sugiu, K1
Nakashimia, H1
Date, I1
Ohmoto, T1
Watanabe, Y1
Faraci, FM1
Heistad, DD1
Ono, K2
Shirotani, T2
Wada, K1
Takahara, T1
Matsushita, Y1
Yuba, K2
Yamana, D2
Fuse, T1
Umezu, M1
Yamamoto, M1
Demura, K1
Nishikawa, Y1
Niwa, Y1
Uehara, H1
Ueda, M1
Samejima, H1
Sugimoto, Y1
Duan, WG1
Yuan, ST1
Liao, H1
Yan, M1
Zhang, LY1
Nishizawa, S1
Shiota, T1
Bernanke, DH1
Parent, AD1
Hasui, K1
Feigin, VL1
Rinkel, GJ1
Algra, A1
Vermeulen, M1
van Gijn, J1
Nakashima, S1
Tabuchi, K1
Shimokawa, S1
Fukuyama, K1
Mineta, T1
Abe, M1
Tachibana, E1
Harada, T3
Saito, K1
Takayasu, M3
Yoshida, J1
Kim, I1
Leinweber, BD1
Morgalla, M1
Butler, WE1
Sasaki, Y1
Peterson, JW1
Morgan, KG1
Takanashi, Y2
Ishida, T2
Meguro, T2
Kiwada, H1
Yamamoto, I1
Masaoka, H1
Takasato, Y1
Nojiri, T1
Hayakawa, T1
Akimoto, H1
Yatsushige, H1
Toumori, H1
Miyazaki, Y1
Honma, M1
Kirchmeier, MJ1
Allen, TM1
Sugita, K4
Hidaka, H6
Saito, I2
Nagata, I1
Kikuchi, H2
Takemae, T2
Okamoto, S1
Kanamori, M1
Okada, T1
Kageyama, N1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Intra-arterial Vasospasm Trial(iVAST)- A Multi-center Randomized Study[NCT01996436]Phase 4330 participants (Anticipated)Interventional2016-08-29Recruiting
Neuroprotective Effect of Dapsone in Patients With Aneurysmal Subarachnoid Hemorrhage: Prospective, Randomized, Double-Blinded, Placebo-Controlled, Clinical Trial[NCT05131295]Phase 349 participants (Actual)Interventional2007-09-05Completed
Efficacy and Safety of Cilostazol-Nimodipine Combined Therapy on Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage (aSAH): A Prospective, Randomized, Double-Blinded, Placebo-Controlled Trial[NCT04148105]Phase 4120 participants (Anticipated)Interventional2019-11-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

8 reviews available for fasudil and Subarachnoid Hemorrhage

ArticleYear
Efficacy of fasudil for the treatment of aneurysmal subarachnoid hemorrhage: A systematic review protocol of randomized controlled trial.
    Medicine, 2019, Volume: 98, Issue:35

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Humans; Intracranial Aneurysm; Randomized Controlled

2019
Pleiotropic effects of the rho-kinase inhibitor fasudil after subarachnoid hemorrhage: a review of preclinical and clinical studies.
    Current vascular pharmacology, 2014, Volume: 12, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Ischemia; Clinical Trials as Topic; Dr

2014
[Japanese Guidelines for the Management of Stroke 2015: overview of the chapter on Subarachnoid Hemorrhage].
    Nihon rinsho. Japanese journal of clinical medicine, 2016, Volume: 74, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antifibrinolytic Agents; Endovascular Procedures; Hum

2016
Vasospasm after aneurysmal subarachnoid hemorrhage: recent advances in endovascular management.
    Current opinion in critical care, 2010, Volume: 16, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angioplasty, Balloon; Critical Care; Endovascular Pro

2010
Systematic assessment and meta-analysis of the efficacy and safety of fasudil in the treatment of cerebral vasospasm in patients with subarachnoid hemorrhage.
    European journal of clinical pharmacology, 2012, Volume: 68, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Cerebral Infarction; Humans; Middle Aged; Prot

2012
[Advances in the study of Rho kinase and its inhibitors].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2007, Volume: 42, Issue:10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Antihypertensive Agents; Cardiovascular Disea

2007
[Basic research and treatment for cerebral vasospasm after subarachnoid hemorrhage: the present and future prospects].
    No shinkei geka. Neurological surgery, 2008, Volume: 36, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Disease; Angioplasty, Balloon; Calcium Channel

2008
Calcium antagonists in patients with aneurysmal subarachnoid hemorrhage: a systematic review.
    Neurology, 1998, Volume: 50, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium Channel Blockers; Humans; Intracranial Aneury

1998

Trials

7 trials available for fasudil and Subarachnoid Hemorrhage

ArticleYear
Clinical trial of nicardipine prolonged-release implants for preventing cerebral vasospasm: multicenter cooperative study in Tokyo.
    Acta neurochirurgica. Supplement, 2011, Volume: 110, Issue:Pt 2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Calcium Channel Blockers; Cooperative Be

2011
Efficacy and safety of fasudil in patients with subarachnoid hemorrhage: final results of a randomized trial of fasudil versus nimodipine.
    Neurologia medico-chirurgica, 2011, Volume: 51, Issue:10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Brain Ischemia; Calcium Channel Blockers

2011
Effect of fasudil hydrochloride, a protein kinase inhibitor, on cerebral vasospasm and delayed cerebral ischemic symptoms after aneurysmal subarachnoid hemorrhage.
    Neurologia medico-chirurgica, 2006, Volume: 46, Issue:9

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Brain Ischemia; Female; Humans; Male; Middle A

2006
A postmarketing surveillance study of fasudil treatment after aneurysmal subarachnoid hemorrhage.
    Surgical neurology, 2007, Volume: 68, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adolescent; Adult; Aged; Cohort Studies; Female; Huma

2007
Intra-arterial infusion of fasudil hydrochloride for treating vasospasm following subarachnoid haemorrhage.
    Acta neurochirurgica, 1999, Volume: 141, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Aneurysm, Ruptured; Female; Humans; Infu

1999
Effect of AT877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Results of a prospective placebo-controlled double-blind trial.
    Journal of neurosurgery, 1992, Volume: 76, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Calcium; Cerebral Infarction; Double-Bli

1992
Dose escalation trial of a novel calcium antagonist, AT877, in patients with aneurysmal subarachnoid haemorrhage.
    Acta neurochirurgica, 1990, Volume: 107, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Blood Pressure; Calcium Channel Blockers

1990

Other Studies

29 other studies available for fasudil and Subarachnoid Hemorrhage

ArticleYear
Real-world data of clazosentan in combination therapy for aneurysmal subarachnoid hemorrhage: a multicenter retrospective cohort study.
    Neurosurgical review, 2023, Aug-09, Volume: 46, Issue:1

    Topics: Aged; Brain Ischemia; Cerebral Infarction; Female; Humans; Middle Aged; Retrospective Studies; Subar

2023
Incidence and Outcomes of Aneurysmal Subarachnoid Hemorrhage: A Multicenter Retrospective Registry-based Descriptive Trial in Kobe City.
    Neurologia medico-chirurgica, 2023, Nov-15, Volume: 63, Issue:11

    Topics: Humans; Incidence; Prognosis; Retrospective Studies; Subarachnoid Hemorrhage; Treatment Outcome; Vas

2023
Critical role of EphA4 in early brain injury after subarachnoid hemorrhage in rat.
    Experimental neurology, 2017, Volume: 296

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood-Brain Barrier; Brain; Brain Edema; Bra

2017
Suppression of the Rho/Rho-kinase pathway and prevention of cerebral vasospasm by combination treatment with statin and fasudil after subarachnoid hemorrhage in rabbit.
    Translational stroke research, 2013, Volume: 4, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Drug Combinations; Enzyme-Li

2013
Prophylactic intra-arterial administration of fasudil hydrochloride for vasospasm following subarachnoid haemorrhage.
    Acta neurochirurgica. Supplement, 2015, Volume: 120

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Aged, 80 and over; Combined Modality The

2015
Effectiveness of intraarterial administration of fasudil hydrochloride for preventing symptomatic vasospasm after subarachnoid hemorrhage.
    Acta neurochirurgica. Supplement, 2015, Volume: 120

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiography, Digital Subtraction; Blood Circulation T

2015
Role of L-type Ca(2+) channels, sarcoplasmic reticulum and Rho kinase in rat basilar artery contractile properties in a new model of subarachnoid hemorrhage.
    Vascular pharmacology, 2015, Volume: 72

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Calcium; Calcium Channel Blo

2015
Safety and efficacy of fasudil monotherapy and fasudil-ozagrel combination therapy in patients with subarachnoid hemorrhage: sub-analysis of the post-marketing surveillance study.
    Neurologia medico-chirurgica, 2008, Volume: 48, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Drug Therapy, Combination; Enzyme Inhibitors; F

2008
[Role of coil embolization and arterial injection in elderly subarachnoid hemorrhage patients: preliminary report].
    No shinkei geka. Neurological surgery, 2008, Volume: 36, Issue:10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Aged, 80 and over; Anesthesia, Local; Embolizat

2008
Convulsion during intra-arterial infusion of fasudil hydrochloride for the treatment of cerebral vasospasm following subarachnoid hemorrhage.
    Neurologia medico-chirurgica, 2010, Volume: 50, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Aged, 80 and over; Anticonvulsants; Cath

2010
Intra-arterial Administration of Fasudil Hydrochloride for Vasospasm Following Subarachnoid Haemorrhage: Experience of 90 Cases.
    Acta neurochirurgica. Supplement, 2011, Volume: 110, Issue:Pt 2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium Channel Blockers; Cerebral Angiography; Femal

2011
Intracranial hemorrhage after intra-arterial administration of fasudil for treatment of cerebral vasospasm following subarachnoid hemorrhage: a serious adverse event.
    Neuroradiology, 2012, Volume: 54, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cerebral Angiography; Embolization, Therapeutic; Fata

2012
Beneficial effect of selective intra-arterial infusion of fasudil hydrochloride as a treatment of symptomatic vasospasm following SAH.
    Acta neurochirurgica. Supplement, 2013, Volume: 115

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Coronary Angiography; Coronary Vasospasm

2013
[A case of convulsion during selective intra-arterial infusion of fasudil hydrochloride for treatment of vasospasm following subarachnoid hemorrhage].
    No shinkei geka. Neurological surgery, 2004, Volume: 32, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Humans; Infusions, Intra-Arterial; Male; Middle Aged;

2004
Activation of Rho-associated kinase during augmented contraction of the basilar artery to serotonin after subarachnoid hemorrhage.
    American journal of physiology. Heart and circulatory physiology, 2005, Volume: 288, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Disease Models, Animal; Enzy

2005
[Intra-arterial administration of fasudil hydrochloride: duration of action].
    No shinkei geka. Neurological surgery, 2005, Volume: 33, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Carotid Artery, Internal; Cerebral Arteries; Ce

2005
[Cerebral circulation dynamics following fasudil intravenous infusion: a CT perfusion study].
    No to shinkei = Brain and nerve, 2005, Volume: 57, Issue:9

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Brain; Cerebrovascular Circulation; Fema

2005
External carotid artery aneurysm developing after embolization of a ruptured posterior inferior cerebellar artery aneurysm in a patient with cervicocephalic fibromuscular dysplasia--case report.
    Neurologia medico-chirurgica, 2006, Volume: 46, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aneurysm, Ruptured; Angiography, Digital Subtr

2006
Intra-arterial administration of fasudil hydrochloride for vasospasm following subarachnoid hemorrhage - analysis of time-density curve with digital subtraction angiography.
    Neurologia medico-chirurgica, 2006, Volume: 46, Issue:11

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Angiography, Digital Subtraction; Brain;

2006
Protein kinase C has two different major roles in lattice compaction enhanced by cerebrospinal fluid from patients with subarachnoid hemorrhage.
    Stroke, 1996, Volume: 27, Issue:10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Cerebrospinal Fluid; Colforsin; Di

1996
Combination therapy of fasudil hydrochloride and ozagrel sodium for cerebral vasospasm following aneurysmal subarachnoid hemorrhage.
    Neurologia medico-chirurgica, 1998, Volume: 38, Issue:12

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Aneurysm, Ruptured; Calcium Channel Bloc

1998
Thin and thick filament regulation of contractility in experimental cerebral vasospasm.
    Neurosurgery, 2000, Volume: 46, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Basilar Artery; Calcium-Binding Prot

2000
Efficacy of intrathecal liposomal fasudil for experimental cerebral vasospasm after subarachnoid hemorrhage.
    Neurosurgery, 2001, Volume: 48, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Dogs; Dose-Response Relation

2001
Clinical effect of Fasudil hydrochloride for cerebral vasospasm following subarachnoid hemorrhage.
    Acta neurochirurgica. Supplement, 2001, Volume: 77

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Aged, 80 and over; Cerebral Angiography;

2001
Intrathecal application with liposome-entrapped Fasudil for cerebral vasospasm following subarachnoid hemorrhage in rats.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2001, Volume: 8, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Drug Delivery Systems; Injec

2001
Possible prophylactic potential of HA1077, a Ca2+ channel antagonist and vasodilator, on chronic cerebral vasospasm.
    European journal of pharmacology, 1992, Sep-22, Volume: 220, Issue:2-3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Calcium; Cerebrovascular Cir

1992
The effects of HA1077 on the cerebral circulation after subarachnoid haemorrhage in dogs.
    Acta neurochirurgica, 1991, Volume: 110, Issue:3-4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Flow Velocity; Blood Volume; Brain; Ca

1991
The effects of an intracellular calcium antagonist HA 1077 on delayed cerebral vasospasm in dogs.
    Acta neurochirurgica, 1988, Volume: 90, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arteries; Calcium Channel Blockers; Cerebral

1988
The effects of HA compound calcium antagonists on delayed cerebral vasospasm in dogs.
    Journal of neurosurgery, 1986, Volume: 65, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Calcium Channel Blockers; Ch

1986