fasudil has been researched along with Renal Insufficiency, Chronic in 3 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
Renal Insufficiency, Chronic: Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We compared the therapeutic effects of fasudil on the spontaneously hypercholesterolemic (SHC) rat, a model of chronic kidney disease (CKD) with proteinuria, with those of the angiotensin receptor blocker olmesartan (OL) by paying attention to the proteinuria and the macrophage phenotype." | 3.79 | Protective effects of Rho kinase inhibitor fasudil on rats with chronic kidney disease. ( Higashi, K; Kumagai, H; Kushiyama, T; Miura, S; Oda, T; Oshima, N; Sakurai, Y; Takechi, H; Uchida, T; Watanabe, A; Yamamoto, K, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kushiyama, T | 1 |
| Oda, T | 1 |
| Yamamoto, K | 1 |
| Higashi, K | 1 |
| Watanabe, A | 1 |
| Takechi, H | 1 |
| Uchida, T | 1 |
| Oshima, N | 1 |
| Sakurai, Y | 1 |
| Miura, S | 1 |
| Kumagai, H | 1 |
| Calò, LA | 1 |
| Vertolli, U | 1 |
| Pagnin, E | 1 |
| Ravarotto, V | 1 |
| Davis, PA | 1 |
| Lupia, M | 1 |
| Naso, E | 1 |
| Maiolino, G | 1 |
| Naso, A | 1 |
| Chu, S | 1 |
| Mao, X | 1 |
| Guo, H | 1 |
| Wang, L | 1 |
| Li, Z | 1 |
| Zhang, Y | 1 |
| Wang, Y | 1 |
| Wang, H | 1 |
| Zhang, X | 1 |
| Peng, W | 1 |
3 other studies available for fasudil and Renal Insufficiency, Chronic
| Article | Year |
|---|---|
Protective effects of Rho kinase inhibitor fasudil on rats with chronic kidney disease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Angiotensin II Type 1 Receptor Blockers; Anim | 2013 |
Increased rho kinase activity in mononuclear cells of dialysis and stage 3-4 chronic kidney disease patients with left ventricular hypertrophy: Cardiovascular risk implications.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Enzyme Activation; Female; Humans; Hyper | 2016 |
Indoxyl sulfate potentiates endothelial dysfunction via reciprocal role for reactive oxygen species and RhoA/ROCK signaling in 5/6 nephrectomized rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Animals; Antioxidants; Cyclic N-Oxides | 2017 |