fasudil has been researched along with Pulmonary Fibrosis in 6 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study was performed to determine the efficacy of ROCK inhibitor fasudil in blocking the development of hyperoxia-induced lung injury and fibrosis in neonatal rats." | 7.81 | Fasudil, an inhibitor of Rho-associated coiled-coil kinase, attenuates hyperoxia-induced pulmonary fibrosis in neonatal rats. ( Dang, HX; Fang, F; Li, J; Ning, W; Qi, XJ; Xu, F, 2015) |
| "To determine the beneficial effects and mechanisms of fasudil, a selective ROCK inhibitor, on bleomycin-induced pulmonary fibrosis in mice and to determine the effects and mechanisms of fasudil on the biological behaviors in NIH3T3 mouse fibroblast cell line." | 7.80 | [Effects of fasudil on bleomycin-induced pulmonary fibrosis in mice and on the biological behaviors in NIH3T3 mouse fibroblast cell line]. ( Huang, H; Jiang, C; Liu, J; Wang, Y; Xu, Z; Zhao, Y, 2014) |
| "Treatment with fasudil (30 mg kg(-1) day(-1)) was given intraperitoneally for 7, 14 or 21 days until mice underwent hemodynamic measurements." | 5.39 | Long-term treatment with fasudil improves bleomycin-induced pulmonary fibrosis and pulmonary hypertension via inhibition of Smad2/3 phosphorylation. ( Batteux, F; Bei, Y; Chen, W; Dinh-Xuan, AT; Duong-Quy, S; Hua-Huy, T; Nguyen, VH; Nicco, C, 2013) |
| " This study was performed to determine the efficacy of ROCK inhibitor fasudil in blocking the development of hyperoxia-induced lung injury and fibrosis in neonatal rats." | 3.81 | Fasudil, an inhibitor of Rho-associated coiled-coil kinase, attenuates hyperoxia-induced pulmonary fibrosis in neonatal rats. ( Dang, HX; Fang, F; Li, J; Ning, W; Qi, XJ; Xu, F, 2015) |
| "To determine the beneficial effects and mechanisms of fasudil, a selective ROCK inhibitor, on bleomycin-induced pulmonary fibrosis in mice and to determine the effects and mechanisms of fasudil on the biological behaviors in NIH3T3 mouse fibroblast cell line." | 3.80 | [Effects of fasudil on bleomycin-induced pulmonary fibrosis in mice and on the biological behaviors in NIH3T3 mouse fibroblast cell line]. ( Huang, H; Jiang, C; Liu, J; Wang, Y; Xu, Z; Zhao, Y, 2014) |
| "Our study aimed firstly to describe pulmonary inflammation and fibrosis induced by HOCl in mice, and secondly to determine whether fasudil, a selective inhibitor of ROCK, could prevent lung and skin fibroses in HOCl-injected mice." | 1.43 | RhoA/Rho-kinase activation promotes lung fibrosis in an animal model of systemic sclerosis. ( Batteux, F; Bei, Y; Chéreau, C; Dinh-Xuan, AT; Duong-Quy, S; Hua-Huy, T; Le-Dong, NN; Nicco, C; Tiev, KP, 2016) |
| "Treatment with fasudil during the postinflammatory fibrotic phase of lung injury or genetic ablation of Mkl1 protected mice from experimental lung fibrosis." | 1.39 | Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis. ( Bernard, K; Desai, L; Hecker, L; Huang, X; Jin, TH; Kurundkar, A; Kurundkar, D; Liu, H; Thannickal, VJ; Zhou, Y, 2013) |
| "Treatment with fasudil (30 mg kg(-1) day(-1)) was given intraperitoneally for 7, 14 or 21 days until mice underwent hemodynamic measurements." | 1.39 | Long-term treatment with fasudil improves bleomycin-induced pulmonary fibrosis and pulmonary hypertension via inhibition of Smad2/3 phosphorylation. ( Batteux, F; Bei, Y; Chen, W; Dinh-Xuan, AT; Duong-Quy, S; Hua-Huy, T; Nguyen, VH; Nicco, C, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, Y | 1 |
| Huang, X | 1 |
| Hecker, L | 1 |
| Kurundkar, D | 1 |
| Kurundkar, A | 1 |
| Liu, H | 1 |
| Jin, TH | 1 |
| Desai, L | 1 |
| Bernard, K | 1 |
| Thannickal, VJ | 1 |
| Bei, Y | 2 |
| Hua-Huy, T | 2 |
| Duong-Quy, S | 2 |
| Nguyen, VH | 1 |
| Chen, W | 1 |
| Nicco, C | 2 |
| Batteux, F | 2 |
| Dinh-Xuan, AT | 2 |
| Jiang, C | 2 |
| Huang, H | 2 |
| Liu, J | 2 |
| Wang, Y | 2 |
| Zhao, Y | 1 |
| Xu, Z | 2 |
| Qi, XJ | 1 |
| Ning, W | 1 |
| Xu, F | 1 |
| Dang, HX | 1 |
| Fang, F | 1 |
| Li, J | 1 |
| Le-Dong, NN | 1 |
| Tiev, KP | 1 |
| Chéreau, C | 1 |
| Lu, Z | 1 |
6 other studies available for fasudil and Pulmonary Fibrosis
| Article | Year |
|---|---|
Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Active Transport, Cell Nucleus; A | 2013 |
Long-term treatment with fasudil improves bleomycin-induced pulmonary fibrosis and pulmonary hypertension via inhibition of Smad2/3 phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bleomycin; Disease Models, Animal; Humans; H | 2013 |
[Effects of fasudil on bleomycin-induced pulmonary fibrosis in mice and on the biological behaviors in NIH3T3 mouse fibroblast cell line].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bleomycin; Cyclin D1; Fibroblasts; Lung; Mat | 2014 |
Fasudil, an inhibitor of Rho-associated coiled-coil kinase, attenuates hyperoxia-induced pulmonary fibrosis in neonatal rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Blotting, Western; Disease | 2015 |
RhoA/Rho-kinase activation promotes lung fibrosis in an animal model of systemic sclerosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Disease Models, Animal; Female; Hypo | 2016 |
Fasudil, a Rho-kinase inhibitor, attenuates bleomycin-induced pulmonary fibrosis in mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bleomycin; Cytokines; Drug Evaluation, Precl | 2012 |