Page last updated: 2024-10-28

fasudil and Pulmonary Arterial Remodeling

fasudil has been researched along with Pulmonary Arterial Remodeling in 4 studies

fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.

Research Excerpts

ExcerptRelevanceReference
"The aim of this study was to investigate the effects of Rho kinase inhibitor-Fasudil on hypoxic pulmonary hypertension (HPH) and pulmonary vascular remodeling in rats."7.80Effects of fasudil on hypoxic pulmonary hypertension and pulmonary vascular remodeling in rats. ( Li, J; Sun, XZ; Tian, XY; Wang, DW, 2014)
"The aim of this study was to investigate the effects of Rho kinase inhibitor-Fasudil on hypoxic pulmonary hypertension (HPH) and pulmonary vascular remodeling in rats."3.80Effects of fasudil on hypoxic pulmonary hypertension and pulmonary vascular remodeling in rats. ( Li, J; Sun, XZ; Tian, XY; Wang, DW, 2014)
"Fasudil‑treated mice developed a significantly smaller intima‑media thickness compared with the untreated mice."1.42Fasudil, a Rho‑kinase inhibitor, prevents intima‑media thickening in a partially ligated carotid artery mouse model: Effects of fasudil in flow‑induced vascular remodeling. ( Gao, F; Li, Q; Li, W; Li, Y; Shen, C; Zhang, T; Zhang, X, 2015)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Li, C1
Liu, PP1
Tang, DD1
Song, R1
Zhang, YQ1
Lei, S1
Wu, SJ1
Zhuang, R1
Wu, J1
Lin, F1
Han, L1
Liang, X1
Meng, Q1
Jiang, Y1
Wang, Z1
Yue, A1
Gu, Y1
Fan, H1
Zhou, X1
Liu, Z1
Sun, XZ1
Tian, XY1
Wang, DW1
Li, J1
Zhang, X2
Zhang, T1
Gao, F1
Li, Q1
Shen, C1
Li, Y1
Li, W1

Other Studies

4 other studies available for fasudil and Pulmonary Arterial Remodeling

ArticleYear
Targeting the RhoA-ROCK pathway to regulate T-cell homeostasis in hypoxia-induced pulmonary arterial hypertension.
    Pulmonary pharmacology & therapeutics, 2018, Volume: 50

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Hypertension, Pulmonary; Hypoxia; Interleuki

2018
Fasudil preserves lung endothelial function and reduces pulmonary vascular remodeling in a rat model of end‑stage pulmonary hypertension with left heart disease.
    International journal of molecular medicine, 2018, Volume: 42, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cardiomegaly; Cell Line; Heart Diseases; Hum

2018
Effects of fasudil on hypoxic pulmonary hypertension and pulmonary vascular remodeling in rats.
    European review for medical and pharmacological sciences, 2014, Volume: 18, Issue:7

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arterioles; Blood Pressure; Carotid Arteries

2014
Fasudil, a Rho‑kinase inhibitor, prevents intima‑media thickening in a partially ligated carotid artery mouse model: Effects of fasudil in flow‑induced vascular remodeling.
    Molecular medicine reports, 2015, Volume: 12, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carotid Arteries; Carotid Intima-Media Thick

2015