fasudil and Pregnancy
fasudil has been researched along with Pregnancy in 11 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to evaluate the effects of fasudil on insulin resistance (IR) in HTR-8/SVneo cells." | 8.02 | Fasudil alleviated insulin resistance through promotion of proliferation, attenuation of cell apoptosis and inflammation and regulation of RhoA/Rho kinase/insulin/nuclear factor-κB signalling pathway in HTR-8/SVneo cells. ( Bai, Y; Du, Q; Du, R; Li, L; Li, P; Tang, L; Zhang, L; Zhang, W, 2021) |
| "The aim of this study was to evaluate the effects of fasudil on insulin resistance (IR) in HTR-8/SVneo cells." | 4.02 | Fasudil alleviated insulin resistance through promotion of proliferation, attenuation of cell apoptosis and inflammation and regulation of RhoA/Rho kinase/insulin/nuclear factor-κB signalling pathway in HTR-8/SVneo cells. ( Bai, Y; Du, Q; Du, R; Li, L; Li, P; Tang, L; Zhang, L; Zhang, W, 2021) |
| "Pretreatment with fasudil, a Rho kinase inhibitor, blunted the effects of 5-HT infusion." | 1.37 | Pulmonary vascular effects of serotonin and selective serotonin reuptake inhibitors in the late-gestation ovine fetus. ( Abman, SH; Delaney, C; Gien, J; Grover, TR; Roe, G, 2011) |
| "Fasudil was injected peritoneally into the neonate, and the ductus was studied 30 min after injection and 60 min after birth." | 1.35 | In vivo dilatation of the ductus arteriosus by Rho kinase inhibition in the rat. ( Momma, K; Nakanishi, T; Sun, F; Toyoshima, K, 2009) |
Research
Studies (11)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Domokos, D | 2 |
| Fülöp, F | 1 |
| Falkay, G | 1 |
| Gáspár, R | 2 |
| Ostendorf, F | 1 |
| Metzdorf, J | 1 |
| Gold, R | 1 |
| Haghikia, A | 1 |
| Tönges, L | 1 |
| Bai, Y | 1 |
| Du, Q | 1 |
| Zhang, L | 1 |
| Li, L | 2 |
| Tang, L | 1 |
| Zhang, W | 1 |
| Du, R | 1 |
| Li, P | 1 |
| Ducza, E | 1 |
| Ergul, M | 1 |
| Turgut, NH | 1 |
| Sarac, B | 1 |
| Altun, A | 1 |
| Yildirim, Ş | 1 |
| Bagcivan, I | 1 |
| Tourneux, P | 1 |
| Chester, M | 1 |
| Grover, T | 1 |
| Abman, SH | 3 |
| Momma, K | 1 |
| Toyoshima, K | 1 |
| Sun, F | 1 |
| Nakanishi, T | 1 |
| Delaney, C | 1 |
| Gien, J | 1 |
| Grover, TR | 2 |
| Roe, G | 2 |
| Butruille, L | 1 |
| Mayeur, S | 1 |
| Duparc, T | 1 |
| Knauf, C | 1 |
| Moitrot, E | 1 |
| Fajardy, I | 1 |
| Valet, P | 1 |
| Storme, L | 1 |
| Deruelle, P | 1 |
| Lesage, J | 1 |
| Ojeda, NB | 1 |
| Royals, TP | 1 |
| Alexander, BT | 1 |
| Parker, TA | 1 |
Other Studies
11 other studies available for fasudil and Pregnancy
| Article | Year |
|---|---|
Effects of newly synthetized isoquinoline derivatives on rat uterine contractility and ROCK II activity.
Topics: Animals; Dose-Response Relationship, Drug; Female; Isoquinolines; Molecular Structure; Pregnancy; Pr | 2018 |
Propionic Acid and Fasudil as Treatment Against Rotenone Toxicity in an In Vitro Model of Parkinson's Disease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Cell Survival; Cells, Cul | 2020 |
Fasudil alleviated insulin resistance through promotion of proliferation, attenuation of cell apoptosis and inflammation and regulation of RhoA/Rho kinase/insulin/nuclear factor-κB signalling pathway in HTR-8/SVneo cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Caspase 3; Cell Survival; Cells, Cultured; | 2021 |
RhoA and Rho-kinase inhibitors modulate cervical resistance: The possible role of RhoA/Rho-kinase signalling pathway in cervical ripening and contractility.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cervical Ripening; Cervix Uteri; Fem | 2019 |
Investigating the effects of the Rho-kinase enzyme inhibitors AS1892802 and fasudil hydrochloride on the contractions of isolated pregnant rat myometrium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Female; Myometrium; Phenylurea Compounds; Pr | 2016 |
Fasudil inhibits the myogenic response in the fetal pulmonary circulation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Pressure; Cardiovascular Agents; Const | 2008 |
In vivo dilatation of the ductus arteriosus by Rho kinase inhibition in the rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Cardiovascular Surgical Pr | 2009 |
Pulmonary vascular effects of serotonin and selective serotonin reuptake inhibitors in the late-gestation ovine fetus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Dose-Response Relationship, Drug; Female; Fe | 2011 |
Prenatal fasudil exposure alleviates fetal growth but programs hyperphagia and overweight in the adult male rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Age Factors; Animals; Female; Fetal Development; Feta | 2012 |
Sex differences in the enhanced responsiveness to acute angiotensin II in growth-restricted rats: role of fasudil, a Rho kinase inhibitor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Blood Pressure; Castration; | 2013 |
Rho kinase activation maintains high pulmonary vascular resistance in the ovine fetal lung.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Dose-Response Relationship, Drug; En | 2006 |