Page last updated: 2024-10-28

fasudil and Pregnancy

fasudil has been researched along with Pregnancy in 11 studies

fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"The aim of this study was to evaluate the effects of fasudil on insulin resistance (IR) in HTR-8/SVneo cells."8.02Fasudil alleviated insulin resistance through promotion of proliferation, attenuation of cell apoptosis and inflammation and regulation of RhoA/Rho kinase/insulin/nuclear factor-κB signalling pathway in HTR-8/SVneo cells. ( Bai, Y; Du, Q; Du, R; Li, L; Li, P; Tang, L; Zhang, L; Zhang, W, 2021)
"The aim of this study was to evaluate the effects of fasudil on insulin resistance (IR) in HTR-8/SVneo cells."4.02Fasudil alleviated insulin resistance through promotion of proliferation, attenuation of cell apoptosis and inflammation and regulation of RhoA/Rho kinase/insulin/nuclear factor-κB signalling pathway in HTR-8/SVneo cells. ( Bai, Y; Du, Q; Du, R; Li, L; Li, P; Tang, L; Zhang, L; Zhang, W, 2021)
"Pretreatment with fasudil, a Rho kinase inhibitor, blunted the effects of 5-HT infusion."1.37Pulmonary vascular effects of serotonin and selective serotonin reuptake inhibitors in the late-gestation ovine fetus. ( Abman, SH; Delaney, C; Gien, J; Grover, TR; Roe, G, 2011)
"Fasudil was injected peritoneally into the neonate, and the ductus was studied 30 min after injection and 60 min after birth."1.35In vivo dilatation of the ductus arteriosus by Rho kinase inhibition in the rat. ( Momma, K; Nakanishi, T; Sun, F; Toyoshima, K, 2009)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (27.27)29.6817
2010's6 (54.55)24.3611
2020's2 (18.18)2.80

Authors

AuthorsStudies
Domokos, D2
Fülöp, F1
Falkay, G1
Gáspár, R2
Ostendorf, F1
Metzdorf, J1
Gold, R1
Haghikia, A1
Tönges, L1
Bai, Y1
Du, Q1
Zhang, L1
Li, L2
Tang, L1
Zhang, W1
Du, R1
Li, P1
Ducza, E1
Ergul, M1
Turgut, NH1
Sarac, B1
Altun, A1
Yildirim, Ş1
Bagcivan, I1
Tourneux, P1
Chester, M1
Grover, T1
Abman, SH3
Momma, K1
Toyoshima, K1
Sun, F1
Nakanishi, T1
Delaney, C1
Gien, J1
Grover, TR2
Roe, G2
Butruille, L1
Mayeur, S1
Duparc, T1
Knauf, C1
Moitrot, E1
Fajardy, I1
Valet, P1
Storme, L1
Deruelle, P1
Lesage, J1
Ojeda, NB1
Royals, TP1
Alexander, BT1
Parker, TA1

Other Studies

11 other studies available for fasudil and Pregnancy

ArticleYear
Effects of newly synthetized isoquinoline derivatives on rat uterine contractility and ROCK II activity.
    Bioorganic & medicinal chemistry letters, 2018, 02-01, Volume: 28, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; Female; Isoquinolines; Molecular Structure; Pregnancy; Pr

2018
Propionic Acid and Fasudil as Treatment Against Rotenone Toxicity in an In Vitro Model of Parkinson's Disease.
    Molecules (Basel, Switzerland), 2020, May-28, Volume: 25, Issue:11

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Cell Survival; Cells, Cul

2020
Fasudil alleviated insulin resistance through promotion of proliferation, attenuation of cell apoptosis and inflammation and regulation of RhoA/Rho kinase/insulin/nuclear factor-κB signalling pathway in HTR-8/SVneo cells.
    The Journal of pharmacy and pharmacology, 2021, Jul-07, Volume: 73, Issue:8

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Caspase 3; Cell Survival; Cells, Cultured;

2021
RhoA and Rho-kinase inhibitors modulate cervical resistance: The possible role of RhoA/Rho-kinase signalling pathway in cervical ripening and contractility.
    European journal of pharmacology, 2019, Jan-15, Volume: 843

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cervical Ripening; Cervix Uteri; Fem

2019
Investigating the effects of the Rho-kinase enzyme inhibitors AS1892802 and fasudil hydrochloride on the contractions of isolated pregnant rat myometrium.
    European journal of obstetrics, gynecology, and reproductive biology, 2016, Volume: 202

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Female; Myometrium; Phenylurea Compounds; Pr

2016
Fasudil inhibits the myogenic response in the fetal pulmonary circulation.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Pressure; Cardiovascular Agents; Const

2008
In vivo dilatation of the ductus arteriosus by Rho kinase inhibition in the rat.
    Neonatology, 2009, Volume: 95, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Cardiovascular Surgical Pr

2009
Pulmonary vascular effects of serotonin and selective serotonin reuptake inhibitors in the late-gestation ovine fetus.
    American journal of physiology. Lung cellular and molecular physiology, 2011, Volume: 301, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Dose-Response Relationship, Drug; Female; Fe

2011
Prenatal fasudil exposure alleviates fetal growth but programs hyperphagia and overweight in the adult male rat.
    European journal of pharmacology, 2012, Aug-15, Volume: 689, Issue:1-3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Age Factors; Animals; Female; Fetal Development; Feta

2012
Sex differences in the enhanced responsiveness to acute angiotensin II in growth-restricted rats: role of fasudil, a Rho kinase inhibitor.
    American journal of physiology. Renal physiology, 2013, Apr-01, Volume: 304, Issue:7

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Blood Pressure; Castration;

2013
Rho kinase activation maintains high pulmonary vascular resistance in the ovine fetal lung.
    American journal of physiology. Lung cellular and molecular physiology, 2006, Volume: 291, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Dose-Response Relationship, Drug; En

2006