fasudil has been researched along with Nervous System Disorders in 5 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of an intracellular calcium antagonist fasudil (HA 1077) on protein synthesis, ion derangement, brain edema, and the neurological signs associated with focal cerebral ischemia, were investigated via a nine-hour occlusion of the left common carotid artery (CCA) in Mongolian gerbils." | 7.69 | Fasudil (HA1077), an intracellular calcium antagonist, improves neurological deficits and tissue potassium loss in focal cerebral ischemia in gerbils. ( Kondoh, Y; Mizusawa, S; Murakami, M; Nagata, K; Nakamichi, H, 1997) |
| " This study analyzed the morphological, biochemical, and functional features of OPHN1-deficient h-iPSCs and their rescue by treatment with the ROCK inhibitor fasudil, shedding light on the relevance of the ROCK pathway during neuronal differentiation and providing a neuronal model for human OPHN1 syndrome and its treatment." | 3.83 | Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell-Derived Neurons With Oligophrenin-1 Loss of Function. ( Alfieri, P; Barresi, S; Bertini, E; Billuart, P; Chiurazzi, P; Compagnucci, C; Petrini, S; Piccini, G; Zanni, G, 2016) |
| "The effects of an intracellular calcium antagonist fasudil (HA 1077) on protein synthesis, ion derangement, brain edema, and the neurological signs associated with focal cerebral ischemia, were investigated via a nine-hour occlusion of the left common carotid artery (CCA) in Mongolian gerbils." | 3.69 | Fasudil (HA1077), an intracellular calcium antagonist, improves neurological deficits and tissue potassium loss in focal cerebral ischemia in gerbils. ( Kondoh, Y; Mizusawa, S; Murakami, M; Nagata, K; Nakamichi, H, 1997) |
| "Ischemic stroke is a deleterious cerebrovascular disease with few therapeutic options, and its functional recovery is highly associated with the integrity of the blood-brain barrier and neuroinflammation." | 1.91 | FDCA Attenuates Neuroinflammation and Brain Injury after Cerebral Ischemic Stroke. ( Guan, X; Huang, Z; Liang, Z; Pang, T; Wang, Y; Wei, D; Wu, J; Xie, L, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guan, X | 1 |
| Wei, D | 1 |
| Liang, Z | 1 |
| Xie, L | 1 |
| Wang, Y | 1 |
| Huang, Z | 1 |
| Wu, J | 1 |
| Pang, T | 1 |
| Compagnucci, C | 1 |
| Barresi, S | 1 |
| Petrini, S | 1 |
| Billuart, P | 1 |
| Piccini, G | 1 |
| Chiurazzi, P | 1 |
| Alfieri, P | 1 |
| Bertini, E | 1 |
| Zanni, G | 1 |
| Lu, Q | 1 |
| Longo, FM | 1 |
| Zhou, H | 1 |
| Massa, SM | 1 |
| Chen, YH | 1 |
| Kondoh, Y | 1 |
| Mizusawa, S | 1 |
| Murakami, M | 1 |
| Nakamichi, H | 1 |
| Nagata, K | 1 |
| Tanaka, Y | 1 |
| Masuzawa, T | 1 |
| Saito, M | 1 |
| Yamada, T | 1 |
| Ebihara, A | 1 |
| Iwasa, H | 1 |
| Mori, S | 1 |
5 other studies available for fasudil and Nervous System Disorders
| Article | Year |
|---|---|
FDCA Attenuates Neuroinflammation and Brain Injury after Cerebral Ischemic Stroke.
Topics: Animals; Blood-Brain Barrier; Brain Injuries; Brain Ischemia; Humans; Infarction, Middle Cerebral Ar | 2023 |
Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell-Derived Neurons With Oligophrenin-1 Loss of Function.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Differentiation; Cell Shape; Cells, Cultured; Cy | 2016 |
Signaling through Rho GTPase pathway as viable drug target.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Aminoquinolines; Anilides; Animals; Benzamide | 2009 |
Fasudil (HA1077), an intracellular calcium antagonist, improves neurological deficits and tissue potassium loss in focal cerebral ischemia in gerbils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Body Water; Brain; Brain Edema; Brain Ischem | 1997 |
Combined administration of Fasudil hydrochloride and nitroglycerin for treatment of cerebral vasospasm.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Brain Ischemia; Drug Combinations; Female; Huma | 2001 |