fasudil has been researched along with Nerve Degeneration in 5 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ahmed, LA | 1 |
| Darwish, HA | 1 |
| Abdelsalam, RM | 1 |
| Amin, HA | 1 |
| Fujimura, M | 1 |
| Usuki, F | 1 |
| Kawamura, M | 1 |
| Izumo, S | 1 |
| Tönges, L | 1 |
| Frank, T | 1 |
| Tatenhorst, L | 1 |
| Saal, KA | 1 |
| Koch, JC | 1 |
| Szego, ÉM | 1 |
| Bähr, M | 1 |
| Weishaupt, JH | 1 |
| Lingor, P | 1 |
| Kitaoka, Y | 2 |
| Kumai, T | 1 |
| Lam, TT | 1 |
| Kuribayashi, K | 1 |
| Isenoumi, K | 1 |
| Munemasa, Y | 1 |
| Motoki, M | 1 |
| Kobayashi, S | 1 |
| Ueno, S | 1 |
| Ito, T | 1 |
| Ohtori, S | 1 |
| Hata, K | 1 |
| Inoue, G | 1 |
| Moriya, H | 1 |
| Takahashi, K | 1 |
| Yamashita, T | 1 |
5 other studies available for fasudil and Nerve Degeneration
| Article | Year |
|---|---|
Role of Rho Kinase Inhibition in the Protective Effect of Fasudil and Simvastatin Against 3-Nitropropionic Acid-Induced Striatal Neurodegeneration and Mitochondrial Dysfunction in Rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; bcl-2-Associated X Protein; Behavior, Animal | 2016 |
Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Botulinum Toxins; Down-Regulation; Male; Met | 2011 |
Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-4-phenylpyridinium; Animals; Axons; Behavior | 2012 |
Involvement of RhoA and possible neuroprotective effect of fasudil, a Rho kinase inhibitor, in NMDA-induced neurotoxicity in the rat retina.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Count; Disease Models, Animal; Drug Int | 2004 |
Rho kinase inhibitor improves motor dysfunction and hypoalgesia in a rat model of lumbar spinal canal stenosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anterior Horn Cells; Axons; Behavior, Animal | 2007 |