Page last updated: 2024-10-28

fasudil and Neoplasms

fasudil has been researched along with Neoplasms in 4 studies

fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
" All 21 drugs are orally bioavailable or topically effective."3.01Small molecule protein kinase inhibitors approved by regulatory agencies outside of the United States. ( Roskoski, R, 2023)
"Approximately 30% of human cancers harbor oncogenic gain-of-function mutations in KRAS."1.38STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability. ( Carr, SA; Fröhling, S; Golub, TR; Jaffe, JD; Luo, T; Masson, K; Ross, NT; Scherer, CA; Scholl, C; Schreiber, SL; Silkworth, W; Stern, AM, 2012)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's2 (50.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Roskoski, R1
Lu, Q1
Longo, FM1
Zhou, H1
Massa, SM1
Chen, YH1
Iorio, F1
Bosotti, R1
Scacheri, E1
Belcastro, V1
Mithbaokar, P1
Ferriero, R1
Murino, L1
Tagliaferri, R1
Brunetti-Pierri, N1
Isacchi, A1
di Bernardo, D1
Luo, T1
Masson, K1
Jaffe, JD1
Silkworth, W1
Ross, NT1
Scherer, CA1
Scholl, C1
Fröhling, S1
Carr, SA1
Stern, AM1
Schreiber, SL1
Golub, TR1

Reviews

1 review available for fasudil and Neoplasms

ArticleYear
Small molecule protein kinase inhibitors approved by regulatory agencies outside of the United States.
    Pharmacological research, 2023, Volume: 194

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antineoplastic Agents; Humans; Neoplasms; Protein Kin

2023

Other Studies

3 other studies available for fasudil and Neoplasms

ArticleYear
Signaling through Rho GTPase pathway as viable drug target.
    Current medicinal chemistry, 2009, Volume: 16, Issue:11

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Aminoquinolines; Anilides; Animals; Benzamide

2009
Discovery of drug mode of action and drug repositioning from transcriptional responses.
    Proceedings of the National Academy of Sciences of the United States of America, 2010, Aug-17, Volume: 107, Issue:33

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Algorithms; Antineoplastic Agents; Autophagy; Blottin

2010
STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability.
    Proceedings of the National Academy of Sciences of the United States of America, 2012, Feb-21, Volume: 109, Issue:8

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Biological Assay; Biomarkers, Tumor; Cell Line, Tumor

2012