fasudil has been researched along with Neoplasm Metastasis in 7 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Injected human leukemic and breast cancer cells exhibited cell-type specific patterns of intravascular distribution with leukemic cells moving faster than breast cancer cells." | 1.56 | Long-term in vivo imaging reveals tumor-specific dissemination and captures host tumor interaction in zebrafish xenografts. ( Asokan, N; Bernas, SN; Bornhäuser, M; Brand, M; Daetwyler, S; Huisken, J; Kempermann, G; Lambert, K; Schmied, C; Vogler, S; Wermke, M; Wobus, M, 2020) |
| "Pancreatic cancer development and metastasis occur in complex settings, with reciprocal feedback from microenvironmental cues influencing both disease progression and drug response." | 1.46 | Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis. ( Adam, AA; Allam, AH; Anderson, KI; Biankin, AV; Boulghourjian, A; Burgess, A; Chantrill, L; Chin, VT; Chou, A; Conway, JR; Cox, TR; Currey, N; Del Monte-Nieto, G; Drury, A; Evans, TR; Froio, D; Gallego-Ortega, D; Gill, AJ; Giry-Laterriere, M; Grey, ST; Harris, NL; Harvey, RP; Herrmann, D; Heu, C; Jain, R; Johns, AL; Kohonen-Corish, M; Lucas, MC; Magenau, A; McCloy, RA; McGhee, EJ; Melenec, P; Morton, JP; Nagrial, AM; Nobis, M; Ormandy, CJ; Pajic, M; Phan, T; Pinese, M; Samra, JS; Samuel, MS; Sansom, OJ; Steinmann, A; Timpson, P; Vennin, C; Walters, SN; Wang, Y; Warren, SC; Weninger, W; Whan, R; Zaratzian, A, 2017) |
| "After treatment to NCI-H446 small cell lung cancer cells with Fasudil, a Rho-kinase inhibitor, cell biological behaviors were observed." | 1.38 | The Rho-kinase inhibitor inhibits proliferation and metastasis of small cell lung cancer. ( Di, J; Liu, J; Lu, J; Shi, W; Yang, X; Zhang, S; Zhang, Y, 2012) |
| "Treatment with fasudil inhibited the growth of 95-D cells in a dose-dependent manner, and the IC50 of fasudil was approximately 0." | 1.36 | The Rho kinase inhibitor fasudil inhibits the migratory behaviour of 95-D lung carcinoma cells. ( Liu, Y; Tian, D; Yang, X; Zong, Z, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Asokan, N | 1 |
| Daetwyler, S | 1 |
| Bernas, SN | 1 |
| Schmied, C | 1 |
| Vogler, S | 1 |
| Lambert, K | 1 |
| Wobus, M | 1 |
| Wermke, M | 1 |
| Kempermann, G | 1 |
| Huisken, J | 1 |
| Brand, M | 1 |
| Bornhäuser, M | 1 |
| Vennin, C | 1 |
| Chin, VT | 1 |
| Warren, SC | 1 |
| Lucas, MC | 1 |
| Herrmann, D | 1 |
| Magenau, A | 1 |
| Melenec, P | 1 |
| Walters, SN | 1 |
| Del Monte-Nieto, G | 1 |
| Conway, JR | 1 |
| Nobis, M | 1 |
| Allam, AH | 1 |
| McCloy, RA | 1 |
| Currey, N | 1 |
| Pinese, M | 1 |
| Boulghourjian, A | 1 |
| Zaratzian, A | 1 |
| Adam, AA | 1 |
| Heu, C | 1 |
| Nagrial, AM | 1 |
| Chou, A | 1 |
| Steinmann, A | 1 |
| Drury, A | 1 |
| Froio, D | 1 |
| Giry-Laterriere, M | 1 |
| Harris, NL | 1 |
| Phan, T | 1 |
| Jain, R | 1 |
| Weninger, W | 1 |
| McGhee, EJ | 1 |
| Whan, R | 1 |
| Johns, AL | 1 |
| Samra, JS | 1 |
| Chantrill, L | 1 |
| Gill, AJ | 1 |
| Kohonen-Corish, M | 1 |
| Harvey, RP | 1 |
| Biankin, AV | 1 |
| Evans, TR | 1 |
| Anderson, KI | 1 |
| Grey, ST | 1 |
| Ormandy, CJ | 1 |
| Gallego-Ortega, D | 1 |
| Wang, Y | 1 |
| Samuel, MS | 1 |
| Sansom, OJ | 1 |
| Burgess, A | 1 |
| Cox, TR | 1 |
| Morton, JP | 1 |
| Pajic, M | 1 |
| Timpson, P | 1 |
| Guerra, FS | 1 |
| Oliveira, RG | 1 |
| Fraga, CAM | 1 |
| Mermelstein, CDS | 1 |
| Fernandes, PD | 1 |
| Woldu, SL | 1 |
| Hutchinson, RC | 1 |
| Krabbe, LM | 1 |
| Sanli, O | 1 |
| Margulis, V | 1 |
| Grise, F | 1 |
| Bidaud, A | 1 |
| Moreau, V | 1 |
| Yang, X | 2 |
| Liu, Y | 1 |
| Zong, Z | 1 |
| Tian, D | 1 |
| Di, J | 1 |
| Zhang, Y | 1 |
| Zhang, S | 1 |
| Lu, J | 1 |
| Liu, J | 1 |
| Shi, W | 1 |
2 reviews available for fasudil and Neoplasm Metastasis
| Article | Year |
|---|---|
The Rho GTPase signalling pathway in urothelial carcinoma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Camellia sinensis; Carcinoma, Transitional Ce | 2018 |
Rho GTPases in hepatocellular carcinoma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Carcinoma, Hepatocellular; Disease P | 2009 |
5 other studies available for fasudil and Neoplasm Metastasis
| Article | Year |
|---|---|
Long-term in vivo imaging reveals tumor-specific dissemination and captures host tumor interaction in zebrafish xenografts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Tra | 2020 |
Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Albumin-Bound Paclitaxel; Animals | 2017 |
ROCK inhibition with Fasudil induces beta-catenin nuclear translocation and inhibits cell migration of MDA-MB 231 human breast cancer cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antineoplastic Agents; beta Catenin; Carcinoma; Cell | 2017 |
The Rho kinase inhibitor fasudil inhibits the migratory behaviour of 95-D lung carcinoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; ATP-Binding Cassette Transporters; Cell Line, Tumor; | 2010 |
The Rho-kinase inhibitor inhibits proliferation and metastasis of small cell lung cancer.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Caspase 3; Cell Adhesion; Cell Line, Tumor | 2012 |