fasudil has been researched along with Muscle Relaxation in 6 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The Rho/Rho-kinase pathway might play an important role in the pathogenesis of LPS-induced endotoxemia, and fasudil could attenuate LPS-induced microvascular permeability, leading to inhibition of endotoxemia." | 7.78 | Fasudil, a Rho-kinase inhibitor, attenuates lipopolysaccharide-induced vascular hyperpermeability and colonic muscle relaxation in guinea pigs. ( Kubota, M; Kuno, M; Nemoto, K; Ninomiya, N; Suzuki, K; Yokota, H, 2012) |
| "Airway smooth muscle contraction is not caused by the increase in intracellular Ca(2+) ([Ca(2+)](i)) alone because agonist stimulation increases tension at the same [Ca(2+)](i) (increase in Ca(2+) sensitivity)." | 5.35 | Rho-kinase inhibitors augment the inhibitory effect of propofol on rat bronchial smooth muscle contraction. ( Chiba, Y; Hanazaki, M; Kohjitani, A; Misawa, M; Morita, K; Sakai, H; Yokoyama, M, 2008) |
| "The Rho/Rho-kinase pathway might play an important role in the pathogenesis of LPS-induced endotoxemia, and fasudil could attenuate LPS-induced microvascular permeability, leading to inhibition of endotoxemia." | 3.78 | Fasudil, a Rho-kinase inhibitor, attenuates lipopolysaccharide-induced vascular hyperpermeability and colonic muscle relaxation in guinea pigs. ( Kubota, M; Kuno, M; Nemoto, K; Ninomiya, N; Suzuki, K; Yokota, H, 2012) |
| "Adenosine (10 microM) was used as other contractile agent for comparison." | 1.35 | Contribution of RhoA kinase and protein kinase C to weak relaxant effect of pinacidil on carbachol-induced contractions in sensitized guinea-pig trachealis. ( Gok, S; Izanli-Paksoy, A; Vural, K, 2009) |
| "Airway smooth muscle contraction is not caused by the increase in intracellular Ca(2+) ([Ca(2+)](i)) alone because agonist stimulation increases tension at the same [Ca(2+)](i) (increase in Ca(2+) sensitivity)." | 1.35 | Rho-kinase inhibitors augment the inhibitory effect of propofol on rat bronchial smooth muscle contraction. ( Chiba, Y; Hanazaki, M; Kohjitani, A; Misawa, M; Morita, K; Sakai, H; Yokoyama, M, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (83.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gok, S | 1 |
| Izanli-Paksoy, A | 1 |
| Vural, K | 1 |
| Tatsumiya, K | 1 |
| Yamanishi, T | 1 |
| Watanabe, M | 1 |
| Masuda, A | 1 |
| Mizuno, T | 1 |
| Kamai, T | 1 |
| Yoshida, K | 1 |
| Suzuki, K | 1 |
| Nemoto, K | 1 |
| Ninomiya, N | 1 |
| Kuno, M | 1 |
| Kubota, M | 1 |
| Yokota, H | 1 |
| Büyükafşar, K | 1 |
| Un, I | 1 |
| Hanazaki, M | 1 |
| Yokoyama, M | 1 |
| Morita, K | 1 |
| Kohjitani, A | 1 |
| Sakai, H | 1 |
| Chiba, Y | 1 |
| Misawa, M | 1 |
| Nakamura, K | 1 |
| Nishimura, J | 1 |
| Hirano, K | 1 |
| Ibayashi, S | 1 |
| Fujishima, M | 1 |
| Kanaide, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Influence of Treatment With the HMG-CoA-Reductase Inhibitor Fluvastatin on Erectile Function in Patients With Cardiovascular Risk-Factors and Erectile Dysfunction[NCT00382161] | Phase 3 | 20 participants (Anticipated) | Interventional | 2006-10-31 | Withdrawn (stopped due to not enough patients meeting inclusion criteria) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 other studies available for fasudil and Muscle Relaxation
| Article | Year |
|---|---|
Contribution of RhoA kinase and protein kinase C to weak relaxant effect of pinacidil on carbachol-induced contractions in sensitized guinea-pig trachealis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Animals; Benzophenanthridines; Bronchodila | 2009 |
Effects of fasudil, a Rho-kinase inhibitor, on contraction of pig bladder tissues with or without urothelium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbachol; Cholinergic Agonists; Dose-Respon | 2009 |
Fasudil, a Rho-kinase inhibitor, attenuates lipopolysaccharide-induced vascular hyperpermeability and colonic muscle relaxation in guinea pigs.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Capillary Permeability; Colon; Coloring Agen | 2012 |
Effects of the Rho-kinase inhibitors, Y-27632 and fasudil, on the corpus cavernosum from diabetic mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Diabetes Mellitus, Experimental; Dos | 2003 |
Rho-kinase inhibitors augment the inhibitory effect of propofol on rat bronchial smooth muscle contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Amides; Animals; Bronchi; Bronchoconst | 2008 |
Hydroxyfasudil, an active metabolite of fasudil hydrochloride, relaxes the rabbit basilar artery by disinhibition of myosin light chain phosphatase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Basilar Artery; Calc | 2001 |