fasudil has been researched along with Muscle Contraction in 45 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Airway smooth muscle contraction is not caused by the increase in intracellular Ca(2+) ([Ca(2+)](i)) alone because agonist stimulation increases tension at the same [Ca(2+)](i) (increase in Ca(2+) sensitivity)." | 5.35 | Rho-kinase inhibitors augment the inhibitory effect of propofol on rat bronchial smooth muscle contraction. ( Chiba, Y; Hanazaki, M; Kohjitani, A; Misawa, M; Morita, K; Sakai, H; Yokoyama, M, 2008) |
| " Fasudil, a selective Rho-kinase inhibitor developed in Japan, is effective for the treatment of a wide range of cardiovascular diseases, with reasonable safety." | 4.84 | Progress of the study of rho-kinase and future perspective of the inhibitor. ( Shimokawa, H; Tawara, S, 2007) |
| "Fasudil treated SJL/J mice showed increased body weight, but decreased grip strength, horizontal activity, and soleus muscle force, compared to untreated SJL/J controls." | 1.36 | Characterization of dysferlin deficient SJL/J mice to assess preclinical drug efficacy: fasudil exacerbates muscle disease phenotype. ( Gordish-Dressman, H; Hoffman, EP; Knoblach, SM; Nagaraju, K; Rayavarapu, S; Van der Meulen, JH, 2010) |
| "Adenosine (10 microM) was used as other contractile agent for comparison." | 1.35 | Contribution of RhoA kinase and protein kinase C to weak relaxant effect of pinacidil on carbachol-induced contractions in sensitized guinea-pig trachealis. ( Gok, S; Izanli-Paksoy, A; Vural, K, 2009) |
| "Airway smooth muscle contraction is not caused by the increase in intracellular Ca(2+) ([Ca(2+)](i)) alone because agonist stimulation increases tension at the same [Ca(2+)](i) (increase in Ca(2+) sensitivity)." | 1.35 | Rho-kinase inhibitors augment the inhibitory effect of propofol on rat bronchial smooth muscle contraction. ( Chiba, Y; Hanazaki, M; Kohjitani, A; Misawa, M; Morita, K; Sakai, H; Yokoyama, M, 2008) |
| "Delayed cerebral vasospasm after subarachnoid hemorrhage (SAH) may be due, in part, to altered regulation of arterial smooth muscle contraction." | 1.33 | Activation of Rho-associated kinase during augmented contraction of the basilar artery to serotonin after subarachnoid hemorrhage. ( Faraci, FM; Heistad, DD; Watanabe, Y, 2005) |
| "When fasudil was combined with ONO-RS-082, fasudil exerted additional inhibition of the tension without further inhibition of the Ser19 phosphorylation." | 1.32 | Inhibition of protein kinase C-mediated contraction by Rho kinase inhibitor fasudil in rabbit aorta. ( Ikeda, M; Ito, K; Iwanaga, T; Sasaki, Y; Seto, M; Shimomura, E; Shiraishi, M, 2004) |
| " The dose-response curve of HA1077 for MLC20 phosphorylation was to the left of the tension curve produced by 40 mM K+." | 1.28 | Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle. ( Hidaka, H; Sasaki, Y; Seto, M, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (11.11) | 18.2507 |
| 2000's | 29 (64.44) | 29.6817 |
| 2010's | 11 (24.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Domokos, D | 1 |
| Ducza, E | 1 |
| Gáspár, R | 1 |
| Porras-González, C | 2 |
| González-Rodríguez, P | 1 |
| Calderón-Sánchez, E | 1 |
| López-Barneo, J | 1 |
| Ureña, J | 2 |
| Egea-Guerrero, JJ | 1 |
| Murillo-Cabezas, F | 1 |
| Muñoz-Sánchez, MÁ | 1 |
| Vilches-Arenas, A | 1 |
| Castellano, A | 1 |
| González-Montelongo, Mdel C | 1 |
| Wang, B | 1 |
| Ding, YM | 1 |
| Wang, CT | 1 |
| Wang, WX | 1 |
| Aydinoglu, F | 1 |
| Ergurhan Kiroglu, O | 1 |
| Astarci, E | 1 |
| Balli, E | 1 |
| Ogulener, N | 1 |
| Behuliak, M | 1 |
| Vavřínová, A | 1 |
| Bencze, M | 1 |
| Polgárová, K | 1 |
| Ergang, P | 1 |
| Kuneš, J | 1 |
| Vaněčková, I | 1 |
| Zicha, J | 1 |
| Sims, SM | 1 |
| Chrones, T | 1 |
| Preiksaitis, HG | 1 |
| Gok, S | 1 |
| Izanli-Paksoy, A | 1 |
| Vural, K | 1 |
| Tatsumiya, K | 1 |
| Yamanishi, T | 1 |
| Watanabe, M | 1 |
| Masuda, A | 1 |
| Mizuno, T | 1 |
| Kamai, T | 1 |
| Yoshida, K | 1 |
| Kizub, IV | 1 |
| Pavlova, OO | 1 |
| Johnson, CD | 1 |
| Soloviev, AI | 1 |
| Zholos, AV | 1 |
| Rayavarapu, S | 1 |
| Van der Meulen, JH | 1 |
| Gordish-Dressman, H | 1 |
| Hoffman, EP | 1 |
| Nagaraju, K | 1 |
| Knoblach, SM | 1 |
| Saito, M | 3 |
| Ohmasa, F | 1 |
| Shomori, K | 1 |
| Dimitriadis, F | 1 |
| Ohiwa, H | 1 |
| Shimizu, S | 1 |
| Tsounapi, P | 1 |
| Kinoshita, Y | 1 |
| Satoh, K | 1 |
| Alford, PW | 2 |
| Dabiri, BE | 1 |
| Goss, JA | 1 |
| Hemphill, MA | 1 |
| Brigham, MD | 1 |
| Parker, KK | 2 |
| Nesmith, AP | 1 |
| Seywerd, JN | 1 |
| Grosberg, A | 1 |
| Ratz, PH | 2 |
| Meehl, JT | 1 |
| Eddinger, TJ | 1 |
| Hoka, S | 1 |
| Shimokawa, H | 2 |
| Büyükafşar, K | 3 |
| Levent, A | 3 |
| Ark, M | 1 |
| Breitenlechner, C | 1 |
| Gassel, M | 1 |
| Hidaka, H | 3 |
| Kinzel, V | 1 |
| Huber, R | 1 |
| Engh, RA | 1 |
| Bossemeyer, D | 1 |
| Nakayama, M | 1 |
| Amano, M | 1 |
| Kawabata, S | 1 |
| Kaibuchi, K | 1 |
| Takefuji, M | 1 |
| Smith, NC | 1 |
| Burnstock, G | 1 |
| Shimomura, E | 1 |
| Shiraishi, M | 1 |
| Iwanaga, T | 1 |
| Seto, M | 4 |
| Sasaki, Y | 6 |
| Ikeda, M | 1 |
| Ito, K | 1 |
| Watanabe, Y | 1 |
| Faraci, FM | 1 |
| Heistad, DD | 1 |
| Amobi, NI | 1 |
| Chung, IP | 1 |
| Smith, IC | 1 |
| Takahashi, R | 1 |
| Nishimura, J | 2 |
| Seki, N | 1 |
| Yunoki, T | 1 |
| Tomoda, T | 1 |
| Kanaide, H | 2 |
| Naito, S | 1 |
| Tawara, S | 1 |
| Teixeira, CE | 1 |
| Jin, L | 1 |
| Priviero, FB | 1 |
| Ying, Z | 1 |
| Webb, RC | 1 |
| Hanazaki, M | 1 |
| Yokoyama, M | 1 |
| Morita, K | 1 |
| Kohjitani, A | 1 |
| Sakai, H | 1 |
| Chiba, Y | 1 |
| Misawa, M | 1 |
| Takizawa, S | 1 |
| Hori, M | 1 |
| Ozaki, H | 1 |
| Karaki, H | 1 |
| Nagumo, H | 2 |
| Sakurada, K | 1 |
| Walsh, MP | 3 |
| Swärd, K | 1 |
| Dreja, K | 1 |
| Susnjar, M | 1 |
| Hellstrand, P | 1 |
| Hartshorne, DJ | 1 |
| Ono, Y | 1 |
| Okamoto, H | 1 |
| Takuwa, Y | 1 |
| Masumoto, N | 1 |
| Tanabe, Y | 1 |
| Nakayama, K | 1 |
| Nakamura, K | 1 |
| Hirano, K | 1 |
| Ibayashi, S | 1 |
| Fujishima, M | 1 |
| Honjo, M | 1 |
| Inatani, M | 1 |
| Kido, N | 1 |
| Sawamura, T | 1 |
| Yue, BY | 1 |
| Honda, Y | 1 |
| Tanihara, H | 1 |
| Zhang, D | 1 |
| Wang, Z | 1 |
| Jin, N | 1 |
| Li, L | 1 |
| Rhoades, RA | 1 |
| Yancey, KW | 1 |
| Swartz, DR | 1 |
| Jezior, JR | 1 |
| Brady, JD | 1 |
| Rosenstein, DI | 1 |
| McCammon, KA | 1 |
| Miner, AS | 1 |
| Satoh, S | 2 |
| Utsunomiya, T | 1 |
| Tsurui, K | 1 |
| Kobayashi, T | 1 |
| Ikegaki, I | 2 |
| Asano, T | 2 |
| Lamping, KG | 1 |
| Rattan, S | 1 |
| Fan, YP | 1 |
| Puri, RN | 1 |
| Mita, M | 1 |
| Yanagihara, H | 1 |
| Hishinuma, S | 1 |
| Shirotani, M | 1 |
| Yui, Y | 1 |
| Hattori, R | 1 |
| Kawai, C | 1 |
| Suzuki, Y | 1 |
| Shibuya, M | 1 |
| Sugita, K | 1 |
3 reviews available for fasudil and Muscle Contraction
| Article | Year |
|---|---|
[Basic and clinical studies on coronary vasospasm].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium Channel Blockers; Coronary Artery Disease; Co | 2002 |
[Involvement of small GTPase Rho and Rho-kinase in the pathogenesis of hypertension and hypertensive target organ damage].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Angina Pectoris; Animals; Arteriosclerosis; C | 2004 |
Progress of the study of rho-kinase and future perspective of the inhibitor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cardiovascular Diseases; Cell Proliferation; | 2007 |
42 other studies available for fasudil and Muscle Contraction
| Article | Year |
|---|---|
RhoA and Rho-kinase inhibitors modulate cervical resistance: The possible role of RhoA/Rho-kinase signalling pathway in cervical ripening and contractility.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cervical Ripening; Cervix Uteri; Fem | 2019 |
Low-dose combination of Rho kinase and L-type Ca(2+) channel antagonists for selective inhibition of depolarization-induced sustained arterial contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arteries; Calcium; Calcium Channel Blockers; | 2014 |
Role of L-type Ca(2+) channels, sarcoplasmic reticulum and Rho kinase in rat basilar artery contractile properties in a new model of subarachnoid hemorrhage.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Calcium; Calcium Channel Blo | 2015 |
Role of ROCK expression in gallbladder smooth muscle contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bile; Cholesterol; Disease Models, Animal; G | 2015 |
Effects of ethanol on RhoA/Rho-kinase-mediated calcium sensitization in mouse lung parenchymal tissue.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Calcium; Ethanol; Lung; Male; Mice; | 2015 |
Ontogenetic changes in contribution of calcium sensitization and calcium entry to blood pressure maintenance of Wistar-Kyoto and spontaneously hypertensive rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arteries; Blood Pressure; Calcium; Calcium C | 2015 |
Calcium sensitization in human esophageal muscle: role for RhoA kinase in maintenance of lower esophageal sphincter tone.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Benzophenanthridines; Calcium; Electric Stimu | 2008 |
Contribution of RhoA kinase and protein kinase C to weak relaxant effect of pinacidil on carbachol-induced contractions in sensitized guinea-pig trachealis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Animals; Benzophenanthridines; Bronchodila | 2009 |
Effects of fasudil, a Rho-kinase inhibitor, on contraction of pig bladder tissues with or without urothelium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbachol; Cholinergic Agonists; Dose-Respon | 2009 |
Rho kinase and protein kinase C involvement in vascular smooth muscle myofilament calcium sensitization in arteries from diabetic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arteries; Benzophenanthridines; Calcium; Dia | 2010 |
Characterization of dysferlin deficient SJL/J mice to assess preclinical drug efficacy: fasudil exacerbates muscle disease phenotype.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Disease Models, Animal; Drug Evaluation, Pre | 2010 |
Rhos and Rho kinases in the rat prostate: their possible functional roles and distributions.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbachol; Immunoblotting; Immunohistochemis | 2011 |
Blast-induced phenotypic switching in cerebral vasospasm.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Algorithms; Arteries; Blast Injuries; Blotting, Weste | 2011 |
Vascular smooth muscle contractility depends on cell shape.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Cell Nucleus; Cell Shape; Cells, | 2011 |
RhoA kinase and protein kinase C participate in regulation of rabbit stomach fundus smooth muscle contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Amides; Animals; Carbachol | 2002 |
Involvement of Rho/Rho-kinase signalling in the contractile activity and acetylcholine release in the mouse gastric fundus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Amides; Animals; Carbachol; Electric S | 2003 |
Expression of Rho-kinase and its functional role in the contractile activity of the mouse vas deferens.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Animals; Blotting, We | 2003 |
Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Amino Acid Sequence; | 2003 |
Expression of Rho-kinase (ROCK-1 and ROCK-2) and its substantial role in the contractile activity of the sheep ureter.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Aorta; Atropine; Blotting, Western; | 2004 |
Mechanisms underlying postjunctional synergism between responses of the vas deferens to noradrenaline and ATP.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adrenergic alpha-Antagonists; | 2004 |
Inhibition of protein kinase C-mediated contraction by Rho kinase inhibitor fasudil in rabbit aorta.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta, Thoracic; Enzyme Activation; In Vitro | 2004 |
Activation of Rho-associated kinase during augmented contraction of the basilar artery to serotonin after subarachnoid hemorrhage.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Disease Models, Animal; Enzy | 2005 |
Attenuation of contractility in rat epididymal vas deferens by Rho kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Animals; Azepines; Ca | 2006 |
RhoA/Rho kinase-mediated Ca2+ sensitization in the contraction of human prostate.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Blotting, Western; Calcium; Cells, Cultured; | 2007 |
Comparative pharmacological analysis of Rho-kinase inhibitors and identification of molecular components of Ca2+ sensitization in the rat lower urinary tract.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Animals; Atropine; Bl | 2007 |
Rho-kinase inhibitors augment the inhibitory effect of propofol on rat bronchial smooth muscle contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Amides; Animals; Bronchi; Bronchoconst | 2008 |
Effects of isoquinoline derivatives, HA1077 and H-7, on cytosolic Ca2+ level and contraction in vascular smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Calcium; Cytosol; Isoquinolines; Male | 1993 |
HA1077, a protein kinase inhibitor, inhibits calponin phosphorylation on Ser175 in porcine coronary artery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arteries; Calcium-Binding Proteins; Calponin | 1998 |
Inhibition of Rho-associated kinase blocks agonist-induced Ca2+ sensitization of myosin phosphorylation and force in guinea-pig ileum.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Carbachol; Cholinergic Agonists; En | 2000 |
Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Blood Proteins; Calcium; Cells, Cultu | 2000 |
Attenuation of pressure-induced myogenic contraction and tyrosine phosphorylation by fasudil, a cerebral vasodilator, in rat cerebral artery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cell-Free System; Cerebral Arteries | 2000 |
Hydroxyfasudil, an active metabolite of fasudil hydrochloride, relaxes the rabbit basilar artery by disinhibition of myosin light chain phosphatase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Basilar Artery; Calc | 2001 |
Effects of protein kinase inhibitor, HA1077, on intraocular pressure and outflow facility in rabbit eyes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Aqueous Humor; Blotting, Western; Ca | 2001 |
Microtubule disruption modulates the Rho-kinase pathway in vascular smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Antineoplastic Agents; Aorta; Azepin | 2001 |
Dependency of detrusor contractions on calcium sensitization and calcium entry through LOE-908-sensitive channels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetamides; Amides; Animals; Bethanechol; Calcium; Ca | 2001 |
Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Brain Ischemia; Cerebral Arteries; Do | 2001 |
Enhanced contractile mechanisms in vasospasm: is endothelial dysfunction the whole story?
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Coronary Vasospasm; Endothelium, Va | 2002 |
Comparison of angiotensin II (Ang II) effects in the internal anal sphincter (IAS) and lower esophageal sphincter smooth muscles.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Anal Canal; Angiotensin II; Animals; Dose-Response Re | 2002 |
Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Arteries; Enzyme Inhibitors; In Vitr | 2002 |
Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta, Thoracic; Dinoprost; In Vitro Techniq | 1991 |
A new type of vasodilator, HA1077, an isoquinoline derivative, inhibits proliferation of bovine vascular smooth muscle cells in culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Calcium; Cattle; Cell Cycle; Cell Div | 1991 |
Endothelin: a potential modulator of cerebral vasospasm.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cerebral Arteries; Dogs; Endothelin | 1990 |