fasudil has been researched along with Memory Disorders in 2 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
Memory Disorders: Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fasudil is a Rho-kinase inhibitor that has shown therapeutic benefits in brain disorders." | 1.48 | Fasudil hydrochloride ameliorates memory deficits in rat model of streptozotocin-induced Alzheimer's disease: Involvement of PI3-kinase, eNOS and NFκB. ( Bansal, N; Kumar, M, 2018) |
| "Fasudil treatment ameliorated learning and memory deficits, accompanied by reduced Aβ deposition, Tau protein phosphorylation, and BACE expression, as well as increased PSD-95 expression in hippocampus." | 1.46 | Multitarget Therapeutic Effect of Fasudil in APP/PS1transgenic Mice. ( Gu, QF; Li, YH; Liu, CY; Ma, CG; Wang, HQ; Wang, Q; Xiao, BG; Yu, JZ; Zhang, GX, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kumar, M | 1 |
| Bansal, N | 1 |
| Yu, JZ | 1 |
| Li, YH | 1 |
| Liu, CY | 1 |
| Wang, Q | 1 |
| Gu, QF | 1 |
| Wang, HQ | 1 |
| Zhang, GX | 1 |
| Xiao, BG | 1 |
| Ma, CG | 1 |
2 other studies available for fasudil and Memory Disorders
| Article | Year |
|---|---|
Fasudil hydrochloride ameliorates memory deficits in rat model of streptozotocin-induced Alzheimer's disease: Involvement of PI3-kinase, eNOS and NFκB.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alzheimer Disease; Animals; Disease Models, Animal; E | 2018 |
Multitarget Therapeutic Effect of Fasudil in APP/PS1transgenic Mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alzheimer Disease; Amyloid beta-Protein Precursor; Am | 2017 |