fasudil has been researched along with MS (Multiple Sclerosis) in 5 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fasudil has been confirmed to improve experimental autoimmune encephalomyelitis (EAE), an animal model of MS." | 1.91 | Hydroxyfasudil regulates immune balance and suppresses inflammatory responses in the treatment of experimental autoimmune encephalomyelitis. ( Chu, GG; Ding, ZB; Huang, JJ; Ma, CG; Song, LJ; Wang, J; Wang, Q; Xiao, BG; Yin, JZ, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chu, GG | 1 |
| Wang, J | 1 |
| Ding, ZB | 1 |
| Yin, JZ | 1 |
| Song, LJ | 1 |
| Wang, Q | 1 |
| Huang, JJ | 1 |
| Xiao, BG | 2 |
| Ma, CG | 3 |
| Yan, Y | 1 |
| Yu, J | 2 |
| Gao, Y | 1 |
| Kumar, G | 1 |
| Guo, M | 1 |
| Zhao, Y | 1 |
| Fang, Q | 1 |
| Zhang, H | 1 |
| Jiang, Y | 1 |
| Zhang, HT | 1 |
| Chen, C | 1 |
| Yu, JZ | 1 |
| Zhang, Q | 1 |
| Zhao, YF | 1 |
| Liu, CY | 1 |
| Li, YH | 1 |
| Yang, WF | 1 |
| LoGrasso, PV | 1 |
| Feng, Y | 1 |
| Huang, XN | 1 |
| Fu, J | 1 |
| Wang, WZ | 1 |
2 reviews available for fasudil and MS (Multiple Sclerosis)
| Article | Year |
|---|---|
Therapeutic potentials of the Rho kinase inhibitor Fasudil in experimental autoimmune encephalomyelitis and the related mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cytokines; Encephalomyelitis, Autoimmune, Ex | 2019 |
Rho kinase (ROCK) inhibitors and their application to inflammatory disorders.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anti-Inflammatory Agents; Asthma; Humans; In | 2009 |
3 other studies available for fasudil and MS (Multiple Sclerosis)
| Article | Year |
|---|---|
Hydroxyfasudil regulates immune balance and suppresses inflammatory responses in the treatment of experimental autoimmune encephalomyelitis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Encephalomyelitis, Autoimmune, Experimental; | 2023 |
Role of Rho Kinase and Fasudil on Synaptic Plasticity in Multiple Sclerosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adolescent; Adult; Animals; Cells, Cultured; Central | 2015 |
The effects of fasudil on the permeability of the rat blood-brain barrier and blood-spinal cord barrier following experimental autoimmune encephalomyelitis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood-Brain Barrier; Cell Membrane Permeabil | 2011 |