fasudil has been researched along with Lung Injury, Acute in 5 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fasudil, which is primarily prescribed to treat cerebral vasospasm, may also inhibit systemic inflammation and prevent sepsis‑induced acute lung injury (ALI) in rats, although the mechanisms remain elusive." | 7.88 | Role of the Rho/ROCK signaling pathway in the protective effects of fasudil against acute lung injury in septic rats. ( Liu, W; Wang, X; Wang, Y; Zhang, L, 2018) |
| "The aim of this study is to evaluate the role of Rho-kinase in the pathogenesis of lung injury induced by intestinal ischemia/reperfusion (I/R) and the preconditioning effects of fasudil hydrochloride." | 7.77 | Inhibition of Rho kinase by fasudil hydrochloride attenuates lung injury induced by intestinal ischemia and reperfusion. ( Fan, Z; Hu, XW; Huang, L; Jing, HR; Li, Y; Liu, KX; Tian, XF; Yao, JH, 2011) |
| "Fasudil, a rock kinase inhibitor, can inhibit systemic inflammation and prevent paraquat (PQ)-induced acute lung injuries in rats; however, the mechanisms for these protective effects remain elusive." | 3.88 | Protective Effects of a Rho Kinase Inhibitor on Paraquat-Induced Acute Lung Injuries in Rats. ( Li, Q; Liu, W; Liu, Z; Zhang, L; Zhao, M, 2018) |
| "Fasudil, which is primarily prescribed to treat cerebral vasospasm, may also inhibit systemic inflammation and prevent sepsis‑induced acute lung injury (ALI) in rats, although the mechanisms remain elusive." | 3.88 | Role of the Rho/ROCK signaling pathway in the protective effects of fasudil against acute lung injury in septic rats. ( Liu, W; Wang, X; Wang, Y; Zhang, L, 2018) |
| "The aim of this study is to evaluate the role of Rho-kinase in the pathogenesis of lung injury induced by intestinal ischemia/reperfusion (I/R) and the preconditioning effects of fasudil hydrochloride." | 3.77 | Inhibition of Rho kinase by fasudil hydrochloride attenuates lung injury induced by intestinal ischemia and reperfusion. ( Fan, Z; Hu, XW; Huang, L; Jing, HR; Li, Y; Liu, KX; Tian, XF; Yao, JH, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wei, J | 1 |
| Wang, P | 1 |
| Li, Y | 2 |
| Dou, Q | 1 |
| Lin, J | 2 |
| Tao, W | 1 |
| Fu, X | 1 |
| Huang, Z | 1 |
| Zhang, W | 1 |
| Zhang, L | 2 |
| Li, Q | 1 |
| Liu, Z | 1 |
| Liu, W | 2 |
| Zhao, M | 1 |
| Wang, Y | 1 |
| Wang, X | 1 |
| Yao, JH | 1 |
| Hu, XW | 1 |
| Fan, Z | 1 |
| Huang, L | 1 |
| Jing, HR | 1 |
| Liu, KX | 1 |
| Tian, XF | 1 |
| Ding, RY | 1 |
| Zhao, DM | 1 |
| Zhang, ZD | 1 |
| Guo, RX | 1 |
| Ma, XC | 1 |
5 other studies available for fasudil and Lung Injury, Acute
| Article | Year |
|---|---|
Inhibition of RHO Kinase by Fasudil Attenuates Ischemic Lung Injury After Cardiac Arrest in Rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Lung Injury; Animals; Blotting, Western; Cytoki | 2018 |
Protective Effects of a Rho Kinase Inhibitor on Paraquat-Induced Acute Lung Injuries in Rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Lung Injury; Animals; Apoptosis; Endothelium, V | 2018 |
Role of the Rho/ROCK signaling pathway in the protective effects of fasudil against acute lung injury in septic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Lung Injury; Animals; Apoptosis; Bronchoalveola | 2018 |
Inhibition of Rho kinase by fasudil hydrochloride attenuates lung injury induced by intestinal ischemia and reperfusion.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Lung Injury; Animals; Interleukin-6; Intestines | 2011 |
Pretreatment of Rho kinase inhibitor inhibits systemic inflammation and prevents endotoxin-induced acute lung injury in mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Lung Injury; Animals; Disease Models, Animal; I | 2011 |