fasudil has been researched along with Kidney Diseases in 9 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Renal fibrosis is the major cause of chronic kidney disease, and the Rho/Rho-associated coiled-coil kinase (ROCK) signaling cascade is involved in the renal fibrotic processes." | 5.42 | Inhibitory effects of fasudil on renal interstitial fibrosis induced by unilateral ureteral obstruction. ( Baba, I; Egi, Y; Kakimoto, T; Suzuki, K; Utsumi, H, 2015) |
| " A selective Rho-kinase inhibitor, fasudil, has recently been shown to improve renal damage resulting from hypertensive glomerulosclerosis, unilateral ureteral obstruction (for interstitial renal fibrosis) and subtotal nephrectomy." | 4.83 | Molecular mechanisms and therapeutic strategies of chronic renal injury: role of rho-kinase in the development of renal injury. ( Hayashi, K; Homma, K; Kanda, T; Saruta, T; Sugano, N; Wakino, S, 2006) |
| "Renal fibrosis is the major cause of chronic kidney disease, and the Rho/Rho-associated coiled-coil kinase (ROCK) signaling cascade is involved in the renal fibrotic processes." | 1.42 | Inhibitory effects of fasudil on renal interstitial fibrosis induced by unilateral ureteral obstruction. ( Baba, I; Egi, Y; Kakimoto, T; Suzuki, K; Utsumi, H, 2015) |
| "Fasudil cotreatment ameliorated CsA-induced changes and restored renal function." | 1.37 | Rho kinase inhibition by fasudil attenuates cyclosporine-induced kidney injury. ( Bae, EH; Kim, IJ; Kim, SW; Lee, JU; Ma, SK; Park, CH; Park, JW, 2011) |
| "Treatment with fasudil or gefitinib completely inhibited glomerular cell proliferation without changing the BP." | 1.37 | Comparison of ROCK and EGFR activation pathways in the progression of glomerular injuries in AngII-infused rats. ( Eguchi, S; Fujigaki, Y; Hishida, A; Suzuki, H; Yamamoto, T, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Gómez, GI | 1 |
| Velarde, V | 1 |
| Sáez, JC | 1 |
| Han, Z | 1 |
| Wang, Z | 1 |
| Song, C | 1 |
| Sheng, J | 1 |
| Niu, X | 1 |
| Qi, P | 1 |
| Baba, I | 1 |
| Egi, Y | 1 |
| Utsumi, H | 1 |
| Kakimoto, T | 1 |
| Suzuki, K | 1 |
| Park, JW | 1 |
| Park, CH | 1 |
| Kim, IJ | 1 |
| Bae, EH | 1 |
| Ma, SK | 1 |
| Lee, JU | 1 |
| Kim, SW | 1 |
| Suzuki, H | 1 |
| Yamamoto, T | 1 |
| Fujigaki, Y | 1 |
| Eguchi, S | 1 |
| Hishida, A | 1 |
| Williams, JM | 1 |
| Johnson, AC | 1 |
| Stelloh, C | 1 |
| Dreisbach, AW | 1 |
| Franceschini, N | 1 |
| Regner, KR | 1 |
| Townsend, RR | 1 |
| Roman, RJ | 1 |
| Garrett, MR | 1 |
| Kanda, T | 3 |
| Wakino, S | 3 |
| Hayashi, K | 3 |
| Homma, K | 2 |
| Ozawa, Y | 1 |
| Saruta, T | 2 |
| Sugano, N | 1 |
2 reviews available for fasudil and Kidney Diseases
| Article | Year |
|---|---|
Molecular mechanisms and therapeutic strategies of chronic renal injury: role of rho-kinase in the development of renal injury.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Cyclin-Dependent Kinase Inhi | 2006 |
Rho/Rho kinase as a potential target for the treatment of renal disease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Disease Models, Animal; Enzyme Inhib | 2005 |
7 other studies available for fasudil and Kidney Diseases
| Article | Year |
|---|---|
Role of a RhoA/ROCK-Dependent Pathway on Renal Connexin43 Regulation in the Angiotensin II-Induced Renal Damage.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Connexin 43; Creatinine; Dis | 2019 |
Fasudil suppresses renal fibrosis in diabetic rats through PI3K/AKT signaling pathway.
Topics: Animals; Diabetes Mellitus, Experimental; Fibrosis; Kidney Diseases; Phosphatidylinositol 3-Kinases; | 2023 |
Inhibitory effects of fasudil on renal interstitial fibrosis induced by unilateral ureteral obstruction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Cell Line; Cell Movement; Collagen T | 2015 |
Rho kinase inhibition by fasudil attenuates cyclosporine-induced kidney injury.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Cyclosporine; Kidney Cortex | 2011 |
Comparison of ROCK and EGFR activation pathways in the progression of glomerular injuries in AngII-infused rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Disease Progression; ErbB Re | 2011 |
Genetic variants in Arhgef11 are associated with kidney injury in the Dahl salt-sensitive rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Congenic; Blood Pressure; Blotting, | 2012 |
Effect of fasudil on Rho-kinase and nephropathy in subtotally nephrectomized spontaneously hypertensive rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Pressure; Cell Cycle Proteins; Cell Di | 2003 |