fasudil has been researched along with Intracranial Aneurysm in 7 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
Intracranial Aneurysm: Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aims to systematically assess the efficacy and safety of fasudil for the treatment of aneurysmal subarachnoid hemorrhage (ASH)." | 9.01 | Efficacy of fasudil for the treatment of aneurysmal subarachnoid hemorrhage: A systematic review protocol of randomized controlled trial. ( Chang, XF; Shen, RB; Song, GF; Wang, HY; Yang, FY; Yang, HW, 2019) |
| " Since September 1995, the combination of fasudil hydrochloride and ozagrel sodium, an inhibitor of thromboxane A2 synthesis, has been used to treat 60 patients at risk of cerebral vasospasm after aneurysmal subarachnoid hemorrhage." | 7.70 | Combination therapy of fasudil hydrochloride and ozagrel sodium for cerebral vasospasm following aneurysmal subarachnoid hemorrhage. ( Abe, M; Fukuyama, K; Mineta, T; Nakashima, S; Shimokawa, S; Tabuchi, K, 1998) |
| "This study aims to systematically assess the efficacy and safety of fasudil for the treatment of aneurysmal subarachnoid hemorrhage (ASH)." | 5.01 | Efficacy of fasudil for the treatment of aneurysmal subarachnoid hemorrhage: A systematic review protocol of randomized controlled trial. ( Chang, XF; Shen, RB; Song, GF; Wang, HY; Yang, FY; Yang, HW, 2019) |
| " Since September 1995, the combination of fasudil hydrochloride and ozagrel sodium, an inhibitor of thromboxane A2 synthesis, has been used to treat 60 patients at risk of cerebral vasospasm after aneurysmal subarachnoid hemorrhage." | 3.70 | Combination therapy of fasudil hydrochloride and ozagrel sodium for cerebral vasospasm following aneurysmal subarachnoid hemorrhage. ( Abe, M; Fukuyama, K; Mineta, T; Nakashima, S; Shimokawa, S; Tabuchi, K, 1998) |
| "Groups 2-4 (n=15 each) were subjected to cerebral aneurysm induction procedures plus 1% NaCl in the drinking water." | 1.36 | Fasudil, a Rho-kinase inhibitor, attenuates induction and progression of cerebral aneurysms: experimental study in rats using vascular corrosion casts. ( Eldawoody, H; Kimura, N; Nakayama, T; Saito, A; Shimizu, H; Takahashi, A; Tominaga, T, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (71.43) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, HY | 1 |
| Song, GF | 1 |
| Yang, HW | 1 |
| Chang, XF | 1 |
| Shen, RB | 1 |
| Yang, FY | 1 |
| Eldawoody, H | 1 |
| Shimizu, H | 1 |
| Kimura, N | 1 |
| Saito, A | 1 |
| Nakayama, T | 1 |
| Takahashi, A | 1 |
| Tominaga, T | 1 |
| Feigin, VL | 1 |
| Rinkel, GJ | 1 |
| Algra, A | 1 |
| Vermeulen, M | 1 |
| van Gijn, J | 1 |
| Nakashima, S | 1 |
| Tabuchi, K | 1 |
| Shimokawa, S | 1 |
| Fukuyama, K | 1 |
| Mineta, T | 1 |
| Abe, M | 1 |
| Tachibana, E | 1 |
| Harada, T | 1 |
| Shibuya, M | 3 |
| Saito, K | 1 |
| Takayasu, M | 1 |
| Suzuki, Y | 3 |
| Yoshida, J | 1 |
| Sugita, K | 2 |
| Saito, I | 2 |
| Sasaki, T | 2 |
| Takakura, K | 2 |
| Nagata, I | 1 |
| Kikuchi, H | 2 |
| Takemae, T | 2 |
| Hidaka, H | 2 |
| Okamoto, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Safety of Cilostazol-Nimodipine Combined Therapy on Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage (aSAH): A Prospective, Randomized, Double-Blinded, Placebo-Controlled Trial[NCT04148105] | Phase 4 | 120 participants (Anticipated) | Interventional | 2019-11-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for fasudil and Intracranial Aneurysm
| Article | Year |
|---|---|
Efficacy of fasudil for the treatment of aneurysmal subarachnoid hemorrhage: A systematic review protocol of randomized controlled trial.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Humans; Intracranial Aneurysm; Randomized Controlled | 2019 |
Calcium antagonists in patients with aneurysmal subarachnoid hemorrhage: a systematic review.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium Channel Blockers; Humans; Intracranial Aneury | 1998 |
3 trials available for fasudil and Intracranial Aneurysm
| Article | Year |
|---|---|
Intra-arterial infusion of fasudil hydrochloride for treating vasospasm following subarachnoid haemorrhage.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Aneurysm, Ruptured; Female; Humans; Infu | 1999 |
Effect of AT877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Results of a prospective placebo-controlled double-blind trial.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Calcium; Cerebral Infarction; Double-Bli | 1992 |
Dose escalation trial of a novel calcium antagonist, AT877, in patients with aneurysmal subarachnoid haemorrhage.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Blood Pressure; Calcium Channel Blockers | 1990 |
2 other studies available for fasudil and Intracranial Aneurysm
| Article | Year |
|---|---|
Fasudil, a Rho-kinase inhibitor, attenuates induction and progression of cerebral aneurysms: experimental study in rats using vascular corrosion casts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Cerebral Arteries; Disease Models, An | 2010 |
Combination therapy of fasudil hydrochloride and ozagrel sodium for cerebral vasospasm following aneurysmal subarachnoid hemorrhage.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Aneurysm, Ruptured; Calcium Channel Bloc | 1998 |