Page last updated: 2024-10-28

fasudil and Intellectual Disability

fasudil has been researched along with Intellectual Disability in 3 studies

fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.

Intellectual Disability: Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)

Research Excerpts

ExcerptRelevanceReference

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (33.33)24.3611
2020's2 (66.67)2.80

Authors

AuthorsStudies
Busti, I1
Allegra, M1
Spalletti, C1
Panzi, C1
Restani, L1
Billuart, P2
Caleo, M1
Martin Lorenzo, S1
Nalesso, V1
Chevalier, C1
Birling, MC1
Herault, Y2
Meziane, H1
Khelfaoui, M1
Morello, N1
Hiba, B1
Calcagno, E1
Reibel-Foisset, S1
Selloum, M1
Chelly, J1
Humeau, Y1
Riet, F1
Zanni, G1
Bienvenu, T1
Giustetto, M1

Other Studies

3 other studies available for fasudil and Intellectual Disability

ArticleYear
ROCK/PKA Inhibition Rescues Hippocampal Hyperexcitability and GABAergic Neuron Alterations in a Oligophrenin-1 Knock-Out Mouse Model of X-Linked Intellectual Disability.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020, 03-25, Volume: 40, Issue:13

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cyclic AMP-Dependent Protein Kinases; Cytosk

2020
Targeting the RHOA pathway improves learning and memory in adult Kctd13 and 16p11.2 deletion mouse models.
    Molecular autism, 2021, 01-13, Volume: 12, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alleles; Animals; Autism Spectrum Disorder; Autistic

2021
Fasudil treatment in adult reverses behavioural changes and brain ventricular enlargement in Oligophrenin-1 mouse model of intellectual disability.
    Human molecular genetics, 2016, 06-01, Volume: 25, Issue:11

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Animals; Autism Spectrum Disorder; Behavior, A

2016