fasudil has been researched along with Injuries, Spinal Cord in 8 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The treatment with fasudil significantly decreased 1) histological damage; 2) motor recovery; 3) nuclear factor-κB (NF-κB) expression; 4) ROK activity; 5) inflammasome activation (caspase-1 and NOD-like receptor family, pyrin domain-containing 3 expression); 6) production of proinflammatory cytokine such as tumor necrosis factor and interleukin-1β (IL-1β); 7) neutrophil infiltration; 8) nitrotyrosine and poly-ADP-ribose formation; 9) glial fibrillary acidic protein expression; 10) apoptosis (terminal deoxynucleotidyl transferase dUTP nick-end labeling staining, FAS ligand expression, and Bax and Bcl-2 expression); and 11) mitogen-activated protein kinase activation (phospho-extracellular signal-regulated kinase and phospho-c-Jun NH(2)-terminal kinase expression)." | 1.38 | Effect of fasudil, a selective inhibitor of Rho kinase activity, in the secondary injury associated with the experimental model of spinal cord trauma. ( Cuzzocrea, S; Esposito, E; Impellizzeri, D; Mazzon, E; Paterniti, I, 2012) |
| "Fasudil treatment also improved axonal continuity, but did not promote functional recovery." | 1.36 | Synergistic effects of bone marrow stromal cells and a Rho kinase (ROCK) inhibitor, fasudil on axon regeneration in rat spinal cord injury. ( Chiba, Y; Hida, K; Hokari, M; Iwasaki, Y; Kuroda, S; Maruichi, K; Osanai, T; Shichinohe, H; Yano, S, 2010) |
| "Spinal cord contusion was induced in rats by applying an aneurysm clip extradurally to the spinal cord at T-3 for 1 minute." | 1.31 | Protein kinase inhibition by fasudil hydrochloride promotes neurological recovery after spinal cord injury in rats. ( Hara, M; Noda, A; Suzuki, Y; Takagi, T; Takayasu, M; Watanabe, K; Yoshida, J, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fu, PC | 1 |
| Tang, RH | 1 |
| Wan, Y | 1 |
| Xie, MJ | 1 |
| Wang, W | 1 |
| Luo, X | 1 |
| Yu, ZY | 1 |
| Furuya, T | 1 |
| Hashimoto, M | 1 |
| Koda, M | 2 |
| Okawa, A | 1 |
| Murata, A | 1 |
| Takahashi, K | 1 |
| Yamashita, T | 2 |
| Yamazaki, M | 1 |
| Chiba, Y | 1 |
| Kuroda, S | 1 |
| Shichinohe, H | 1 |
| Hokari, M | 1 |
| Osanai, T | 1 |
| Maruichi, K | 1 |
| Yano, S | 1 |
| Hida, K | 1 |
| Iwasaki, Y | 1 |
| Baba, H | 1 |
| Tanoue, Y | 1 |
| Maeda, T | 1 |
| Kobayashi, M | 1 |
| Oda, S | 1 |
| Tominaga, R | 1 |
| Impellizzeri, D | 1 |
| Mazzon, E | 1 |
| Paterniti, I | 1 |
| Esposito, E | 1 |
| Cuzzocrea, S | 1 |
| Sung, JK | 1 |
| Miao, L | 1 |
| Calvert, JW | 1 |
| Huang, L | 1 |
| Louis Harkey, H | 1 |
| Zhang, JH | 1 |
| Nishio, Y | 1 |
| Kitajo, K | 1 |
| Seto, M | 1 |
| Hata, K | 1 |
| Taniguchi, J | 1 |
| Moriya, H | 1 |
| Fujitani, M | 1 |
| Kubo, T | 1 |
| Hara, M | 1 |
| Takayasu, M | 1 |
| Watanabe, K | 1 |
| Noda, A | 1 |
| Takagi, T | 1 |
| Suzuki, Y | 1 |
| Yoshida, J | 1 |
8 other studies available for fasudil and Injuries, Spinal Cord
| Article | Year |
|---|---|
ROCK inhibition with fasudil promotes early functional recovery of spinal cord injury in rats by enhancing microglia phagocytosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Male; Microglia; Myelin Basic Pro | 2016 |
Treatment of rat spinal cord injury with a Rho-kinase inhibitor and bone marrow stromal cell transplantation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Bone Marrow Cells; Bon | 2009 |
Synergistic effects of bone marrow stromal cells and a Rho kinase (ROCK) inhibitor, fasudil on axon regeneration in rat spinal cord injury.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Axons; Bone Marrow Transplantation; Combined | 2010 |
Protective effects of cold spinoplegia with fasudil against ischemic spinal cord injury in rabbits.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anterior Horn Cells; Aorta; Constriction; Di | 2010 |
Effect of fasudil, a selective inhibitor of Rho kinase activity, in the secondary injury associated with the experimental model of spinal cord trauma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Disease Models, Animal; Male; Mice; Protein | 2012 |
A possible role of RhoA/Rho-kinase in experimental spinal cord injury in rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; ADP Ribose Transferases; Amides; Animals; Blotting, W | 2003 |
Delayed treatment with Rho-kinase inhibitor does not enhance axonal regeneration or functional recovery after spinal cord injury in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Behavior, Animal; Biotin; Dextrans; Disease | 2006 |
Protein kinase inhibition by fasudil hydrochloride promotes neurological recovery after spinal cord injury in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Behavior, Animal; Cont | 2000 |