fasudil has been researched along with Endotoxemia in 4 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
Endotoxemia: A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The Rho/Rho-kinase pathway might play an important role in the pathogenesis of LPS-induced endotoxemia, and fasudil could attenuate LPS-induced microvascular permeability, leading to inhibition of endotoxemia." | 7.78 | Fasudil, a Rho-kinase inhibitor, attenuates lipopolysaccharide-induced vascular hyperpermeability and colonic muscle relaxation in guinea pigs. ( Kubota, M; Kuno, M; Nemoto, K; Ninomiya, N; Suzuki, K; Yokota, H, 2012) |
| "The Rho/Rho-kinase pathway might play an important role in the pathogenesis of LPS-induced endotoxemia, and fasudil could attenuate LPS-induced microvascular permeability, leading to inhibition of endotoxemia." | 3.78 | Fasudil, a Rho-kinase inhibitor, attenuates lipopolysaccharide-induced vascular hyperpermeability and colonic muscle relaxation in guinea pigs. ( Kubota, M; Kuno, M; Nemoto, K; Ninomiya, N; Suzuki, K; Yokota, H, 2012) |
| " This study aimed to determine whether the Rho kinase (ROCK) inhibitor fasudil protected against LPS-induced (endotoxemia) macromolecular leak and leukocyte adhesion via NOS pathways." | 3.77 | ROCK induced inflammation of the microcirculation during endotoxemia mediated by nitric oxide synthase. ( Brookes, ZL; Brown, NJ; Hellewell, PG; McGown, CC, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Preau, S | 1 |
| Delguste, F | 1 |
| Yu, Y | 1 |
| Remy-Jouet, I | 1 |
| Richard, V | 1 |
| Saulnier, F | 1 |
| Boulanger, E | 1 |
| Neviere, R | 1 |
| McGown, CC | 1 |
| Brown, NJ | 1 |
| Hellewell, PG | 1 |
| Brookes, ZL | 1 |
| Suzuki, K | 1 |
| Nemoto, K | 1 |
| Ninomiya, N | 1 |
| Kuno, M | 1 |
| Kubota, M | 1 |
| Yokota, H | 1 |
| Thorlacius, K | 1 |
| Slotta, JE | 1 |
| Laschke, MW | 1 |
| Wang, Y | 1 |
| Menger, MD | 1 |
| Jeppsson, B | 1 |
| Thorlacius, H | 1 |
4 other studies available for fasudil and Endotoxemia
| Article | Year |
|---|---|
Endotoxemia Engages the RhoA Kinase Pathway to Impair Cardiac Function By Altering Cytoskeleton, Mitochondrial Fission, and Autophagy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Depolymerizing Factors; Animals; Autophagy; Cal | 2016 |
ROCK induced inflammation of the microcirculation during endotoxemia mediated by nitric oxide synthase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Pressure; Capillary Permeability; Cell | 2011 |
Fasudil, a Rho-kinase inhibitor, attenuates lipopolysaccharide-induced vascular hyperpermeability and colonic muscle relaxation in guinea pigs.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Capillary Permeability; Colon; Coloring Agen | 2012 |
Protective effect of fasudil, a Rho-kinase inhibitor, on chemokine expression, leukocyte recruitment, and hepatocellular apoptosis in septic liver injury.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Apoptosis; Cell Communication; Chemo | 2006 |