fasudil has been researched along with Elevated Cholesterol in 6 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The current study was designed to investigate the potential beneficial therapeutic outcome of Rho kinase inhibitor (fasudil) against hypercholesterolemia-induced myocardial and vascular injury in rabbits together with diet modification." | 7.85 | Rho kinase inhibitor fasudil mitigates high-cholesterol diet-induced hypercholesterolemia and vascular damage. ( Abdali, NT; Ibrahim, TM; Said, E; Yaseen, AH, 2017) |
| "The current study was designed to investigate the potential beneficial therapeutic outcome of Rho kinase inhibitor (fasudil) against hypercholesterolemia-induced myocardial and vascular injury in rabbits together with diet modification." | 3.85 | Rho kinase inhibitor fasudil mitigates high-cholesterol diet-induced hypercholesterolemia and vascular damage. ( Abdali, NT; Ibrahim, TM; Said, E; Yaseen, AH, 2017) |
| "Fasudil may induce preconditioning and postconditioning against myocardial ischemia‑reperfusion injury in normal rats, however, their effectivenesses in hypercholesterolemia remains to be determined." | 3.80 | High‑dose fasudil preconditioning and postconditioning attenuate myocardial ischemia‑reperfusion injury in hypercholesterolemic rats. ( Jia, D; Wu, N; Zhang, X, 2014) |
| " We compared the therapeutic effects of fasudil on the spontaneously hypercholesterolemic (SHC) rat, a model of chronic kidney disease (CKD) with proteinuria, with those of the angiotensin receptor blocker olmesartan (OL) by paying attention to the proteinuria and the macrophage phenotype." | 3.79 | Protective effects of Rho kinase inhibitor fasudil on rats with chronic kidney disease. ( Higashi, K; Kumagai, H; Kushiyama, T; Miura, S; Oda, T; Oshima, N; Sakurai, Y; Takechi, H; Uchida, T; Watanabe, A; Yamamoto, K, 2013) |
| "Fasudil was administered 15 min prior to ischemia, and wortmannin and L‑NAME were administered following IPoC." | 1.40 | Inhibition of Rho-kinase by fasudil restores the cardioprotection of ischemic postconditioninng in hypercholesterolemic rat heart. ( Jia, D; Li, W; Lv, Y; Shu, W; Wu, N, 2014) |
| "2." | 1.37 | Rho kinase inhibition by fasudil exerts antioxidant effects in hypercholesterolemic rats. ( Cao, G; Chu, L; Ji, E; Li, G; Ma, Z; Zhang, J, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kushiyama, T | 1 |
| Oda, T | 1 |
| Yamamoto, K | 1 |
| Higashi, K | 1 |
| Watanabe, A | 1 |
| Takechi, H | 1 |
| Uchida, T | 1 |
| Oshima, N | 1 |
| Sakurai, Y | 1 |
| Miura, S | 1 |
| Kumagai, H | 1 |
| Wu, N | 2 |
| Zhang, X | 1 |
| Jia, D | 2 |
| Li, W | 1 |
| Shu, W | 1 |
| Lv, Y | 1 |
| Abdali, NT | 1 |
| Yaseen, AH | 1 |
| Said, E | 1 |
| Ibrahim, TM | 1 |
| Ma, Z | 2 |
| Zhang, J | 2 |
| Ji, E | 2 |
| Cao, G | 1 |
| Li, G | 1 |
| Chu, L | 2 |
| Du, R | 1 |
6 other studies available for fasudil and Elevated Cholesterol
| Article | Year |
|---|---|
Protective effects of Rho kinase inhibitor fasudil on rats with chronic kidney disease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Angiotensin II Type 1 Receptor Blockers; Anim | 2013 |
High‑dose fasudil preconditioning and postconditioning attenuate myocardial ischemia‑reperfusion injury in hypercholesterolemic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Heart; Humans; Hypercholesterolemia; KATP Ch | 2014 |
Inhibition of Rho-kinase by fasudil restores the cardioprotection of ischemic postconditioninng in hypercholesterolemic rat heart.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Androstadienes; Animals; Apoptosis; Cholesterol; Coro | 2014 |
Rho kinase inhibitor fasudil mitigates high-cholesterol diet-induced hypercholesterolemia and vascular damage.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alanine Transaminase; Animals; Aorta; Aspartate Amino | 2017 |
Rho kinase inhibition by fasudil exerts antioxidant effects in hypercholesterolemic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Cholesterol, Dietary; Disease | 2011 |
Rho kinase inhibition by fasudil has anti-inflammatory effects in hypercholesterolemic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anti-Inflammatory Agents; Aorta, Thoracic; H | 2011 |