fasudil has been researched along with Diabetic Cardiomyopathies in 4 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
Diabetic Cardiomyopathies: Diabetes complications in which VENTRICULAR REMODELING in the absence of CORONARY ATHEROSCLEROSIS and hypertension results in cardiac dysfunctions, typically LEFT VENTRICULAR DYSFUNCTION. The changes also result in myocardial hypertrophy, myocardial necrosis and fibrosis, and collagen deposition due to impaired glucose tolerance.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with fasudil, a ROCK inhibitor, significantly protected against diabetes-induced myocardial hypertrophy, fibrosis and mitochondrial dysfunction." | 1.91 | Speckle-tracking echocardiography provides sensitive measurements of subtle early alterations associated with cardiac dysfunction in T2DM rats. ( Chen, Z; Guo, B; Li, Y; Liu, G; Liu, S; Liu, Z; Ma, M; Qi, Y; Wang, L; Xue, L; Yin, Y, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Qi, Y | 1 |
| Chen, Z | 1 |
| Guo, B | 1 |
| Liu, Z | 1 |
| Wang, L | 1 |
| Liu, S | 1 |
| Xue, L | 1 |
| Ma, M | 1 |
| Yin, Y | 1 |
| Li, Y | 1 |
| Liu, G | 1 |
| Waddingham, MT | 1 |
| Edgley, AJ | 1 |
| Astolfo, A | 1 |
| Inagaki, T | 1 |
| Fujii, Y | 1 |
| Du, CK | 1 |
| Zhan, DY | 1 |
| Tsuchimochi, H | 1 |
| Yagi, N | 1 |
| Kelly, DJ | 1 |
| Shirai, M | 1 |
| Pearson, JT | 1 |
| Gao, H | 1 |
| Hou, F | 1 |
| Dong, R | 1 |
| Wang, Z | 1 |
| Zhao, C | 1 |
| Tang, W | 1 |
| Wu, Y | 1 |
| Guan, SJ | 1 |
| Ma, ZH | 1 |
| Wu, YL | 1 |
| Zhang, JP | 1 |
| Liang, F | 1 |
| Weiss, JW | 1 |
| Guo, QY | 1 |
| Wang, JY | 1 |
| Ji, ES | 1 |
| Chu, L | 1 |
4 other studies available for fasudil and Diabetic Cardiomyopathies
| Article | Year |
|---|---|
Speckle-tracking echocardiography provides sensitive measurements of subtle early alterations associated with cardiac dysfunction in T2DM rats.
Topics: Animals; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Echocardiography; Rats; Ventricular D | 2023 |
Chronic Rho-kinase inhibition improves left ventricular contractile dysfunction in early type-1 diabetes by increasing myosin cross-bridge extension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Diabetes Mellitus, Experimental; Dia | 2015 |
Rho-Kinase inhibitor fasudil suppresses high glucose-induced H9c2 cell apoptosis through activation of autophagy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Au | 2016 |
Long-term administration of fasudil improves cardiomyopathy in streptozotocin-induced diabetic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin-Converting Enzyme Inhibitors; Animals; An | 2012 |