fasudil has been researched along with Diabetes Mellitus in 5 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This research aimed to the study influence of fasudil (FAS) on myocardial fibrosis in rats with diabetes mellitus (DM) via the transforming growth factor-beta 1 (TGF-β1)/ small mothers against decapentaplegic (Smad) signaling pathway." | 8.31 | Fasudil attenuates myocardial fibrosis in rats with diabetes mellitus via TGF-β1/Smad signaling pathway. ( Liu, Y; Song, J; Su, F; Wang, F; Zhang, P, 2023) |
| "This study evaluates the effect of intravitreal injection of a Rho-associated protein kinase (ROCK) inhibitor, fasudil, on diabetic macular edema (DME) with an unfavorable response." | 8.12 | Intravitreal Fasudil for Treatment of Diabetic Macular Edema with an Unfavorable Response. ( Machida, S; Muto, T, 2022) |
| "This research aimed to the study influence of fasudil (FAS) on myocardial fibrosis in rats with diabetes mellitus (DM) via the transforming growth factor-beta 1 (TGF-β1)/ small mothers against decapentaplegic (Smad) signaling pathway." | 4.31 | Fasudil attenuates myocardial fibrosis in rats with diabetes mellitus via TGF-β1/Smad signaling pathway. ( Liu, Y; Song, J; Su, F; Wang, F; Zhang, P, 2023) |
| "This study evaluates the effect of intravitreal injection of a Rho-associated protein kinase (ROCK) inhibitor, fasudil, on diabetic macular edema (DME) with an unfavorable response." | 4.12 | Intravitreal Fasudil for Treatment of Diabetic Macular Edema with an Unfavorable Response. ( Machida, S; Muto, T, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, P | 1 |
| Wang, F | 1 |
| Song, J | 1 |
| Su, F | 1 |
| Liu, Y | 1 |
| Muto, T | 1 |
| Machida, S | 1 |
| Ding, R | 1 |
| Hu, DY | 1 |
| Xia, K | 1 |
| Yang, XC | 1 |
| Gurpinar, T | 1 |
| Gok, S | 1 |
| Li, H | 1 |
| Peng, W | 1 |
| Jian, W | 1 |
| Li, Y | 1 |
| Li, Q | 1 |
| Li, W | 1 |
| Xu, Y | 1 |
1 trial available for fasudil and Diabetes Mellitus
| Article | Year |
|---|---|
ROCK inhibitor fasudil attenuated high glucose-induced MCP-1 and VCAM-1 expression and monocyte-endothelial cell adhesion.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Anti-Inflammatory Agents; Blotting, Western; Ce | 2012 |
4 other studies available for fasudil and Diabetes Mellitus
| Article | Year |
|---|---|
Fasudil attenuates myocardial fibrosis in rats with diabetes mellitus via TGF-β1/Smad signaling pathway.
Topics: Animals; Cardiomyopathies; Collagen; Diabetes Mellitus; Fibrosis; Interleukin-1; Interleukin-6; Rats | 2023 |
Intravitreal Fasudil for Treatment of Diabetic Macular Edema with an Unfavorable Response.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Diabetes Mellitus; Diabetic Retinopathy; Humans | 2022 |
Increased RhoA/ROK mRNA expression and function in diabetic vein grafts compared with nondiabetic vein grafts and diabetic arterial grafts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Case-Control Studies; Coronary Artery By | 2010 |
Vasodilator effects of cromakalim and HA 1077 in diabetic rat aorta.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Cromakalim; Diabetes Mellitus; In Vit | 2012 |