fasudil has been researched along with Diabetes Mellitus, Type 2 in 7 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with fasudil, a ROCK inhibitor, significantly protected against diabetes-induced myocardial hypertrophy, fibrosis and mitochondrial dysfunction." | 1.91 | Speckle-tracking echocardiography provides sensitive measurements of subtle early alterations associated with cardiac dysfunction in T2DM rats. ( Chen, Z; Guo, B; Li, Y; Liu, G; Liu, S; Liu, Z; Ma, M; Qi, Y; Wang, L; Xue, L; Yin, Y, 2023) |
| "Non-alcoholic fatty liver disease (NAFLD) is linked to type 2 diabetes mellitus (T2DM), obesity, and insulin resistance." | 1.72 | Rho-kinase inhibition ameliorates non-alcoholic fatty liver disease in type 2 diabetic rats. ( Abdullah, DM; Al-Zahaby, SA; Ebrahim, HA; Elkattawy, HA; Elsherbini, DM; Hassan, AE; Noser, Y, 2022) |
| "A rat model of type 2 diabetes was established by high fat diet combined with streptozotocin (30 mg/kg, intraperitoneal injection)." | 1.40 | Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, ameliorates hepatic fibrosis in rats with type 2 diabetes. ( Deng, Y; Fang, C; Meng, F; Wang, M; Zhang, L; Zhou, H, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Elkattawy, HA | 1 |
| Elsherbini, DM | 1 |
| Ebrahim, HA | 1 |
| Abdullah, DM | 1 |
| Al-Zahaby, SA | 1 |
| Noser, Y | 1 |
| Hassan, AE | 1 |
| Qi, Y | 1 |
| Chen, Z | 1 |
| Guo, B | 1 |
| Liu, Z | 1 |
| Wang, L | 1 |
| Liu, S | 1 |
| Xue, L | 1 |
| Ma, M | 1 |
| Yin, Y | 1 |
| Li, Y | 1 |
| Liu, G | 1 |
| Rothschild, PR | 1 |
| Salah, S | 1 |
| Berdugo, M | 1 |
| Gélizé, E | 1 |
| Delaunay, K | 1 |
| Naud, MC | 1 |
| Klein, C | 1 |
| Moulin, A | 1 |
| Savoldelli, M | 1 |
| Bergin, C | 1 |
| Jeanny, JC | 1 |
| Jonet, L | 1 |
| Arsenijevic, Y | 1 |
| Behar-Cohen, F | 1 |
| Crisanti, P | 1 |
| Matoba, K | 1 |
| Kawanami, D | 1 |
| Okada, R | 1 |
| Tsukamoto, M | 1 |
| Kinoshita, J | 1 |
| Ito, T | 1 |
| Ishizawa, S | 1 |
| Kanazawa, Y | 1 |
| Yokota, T | 1 |
| Murai, N | 1 |
| Matsufuji, S | 1 |
| Takahashi-Fujigasaki, J | 1 |
| Utsunomiya, K | 1 |
| Guo, R | 2 |
| Liu, B | 1 |
| Zhou, S | 1 |
| Zhang, B | 1 |
| Xu, Y | 2 |
| Su, Y | 1 |
| Yan, J | 1 |
| Sun, H | 1 |
| Wu, J | 1 |
| Liu, W | 1 |
| Zhou, H | 1 |
| Fang, C | 1 |
| Zhang, L | 1 |
| Deng, Y | 1 |
| Wang, M | 1 |
| Meng, F | 1 |
1 trial available for fasudil and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Fasudil improves short-term echocardiographic parameters of diastolic function in patients with type 2 diabetes with preserved left ventricular ejection fraction: a pilot study.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Diabetes Mellitus, Type 2; Diastole; Echocardio | 2015 |
6 other studies available for fasudil and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Rho-kinase inhibition ameliorates non-alcoholic fatty liver disease in type 2 diabetic rats.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; In | 2022 |
Speckle-tracking echocardiography provides sensitive measurements of subtle early alterations associated with cardiac dysfunction in T2DM rats.
Topics: Animals; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Echocardiography; Rats; Ventricular D | 2023 |
ROCK-1 mediates diabetes-induced retinal pigment epithelial and endothelial cell blebbing: Contribution to diabetic retinopathy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Animals; Biomarkers; Case-Control Studies; Cyto | 2017 |
Rho-kinase inhibition prevents the progression of diabetic nephropathy by downregulating hypoxia-inducible factor 1α.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Albuminuria; Animals; Diabetes Mellitus, Type 2; Diab | 2013 |
The protective effect of fasudil on the structure and function of cardiac mitochondria from rats with type 2 diabetes induced by streptozotocin with a high-fat diet is mediated by the attenuation of oxidative stress.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Biomarkers; Cardiotonic Agents; Diabetes Mel | 2013 |
Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, ameliorates hepatic fibrosis in rats with type 2 diabetes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Connective Tissue Growth Factor; Diabetes Me | 2014 |