Page last updated: 2024-10-28

fasudil and Degenerative Diseases, Central Nervous System

fasudil has been researched along with Degenerative Diseases, Central Nervous System in 3 studies

fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.

Research Excerpts

ExcerptRelevanceReference
"Fasudil is a Rho kinase inhibitor and has been reported to have neuroprotective effects."1.39Rho kinase inhibitor fasudil protects against β-amyloid-induced hippocampal neurodegeneration in rats. ( Chen, X; Gao, W; Song, Y; Wang, LY; Zhu, MJ, 2013)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (33.33)24.3611
2020's2 (66.67)2.80

Authors

AuthorsStudies
Killick, R1
Elliott, C1
Ribe, E1
Broadstock, M1
Ballard, C1
Aarsland, D1
Williams, G1
Lingli, C1
Hongmei, N1
Penghuan, J1
Hongli, Z1
Yuye, L1
Rui, W1
Fei, R1
Zhihong, Y1
Dongfang, H1
Yaming, G1
Song, Y1
Chen, X1
Wang, LY1
Gao, W1
Zhu, MJ1

Reviews

1 review available for fasudil and Degenerative Diseases, Central Nervous System

ArticleYear
Neurodegenerative Disease Associated Pathways in the Brains of Triple Transgenic Alzheimer's Model Mice Are Reversed Following Two Weeks of Peripheral Administration of Fasudil.
    International journal of molecular sciences, 2023, Jul-07, Volume: 24, Issue:13

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alzheimer Disease; Animals; Brain; Mice; Mice, Transg

2023

Other Studies

2 other studies available for fasudil and Degenerative Diseases, Central Nervous System

ArticleYear
Inhibition of RhoA/ROCK signalling pathway activity improves neural damage and cognitive deficits in the fluorosis model.
    Ecotoxicology and environmental safety, 2023, Nov-01, Volume: 266

    Topics: Animals; Cognition; Cognitive Dysfunction; Fluorides; Humans; Mice; Mice, Inbred ICR; Neurodegenerat

2023
Rho kinase inhibitor fasudil protects against β-amyloid-induced hippocampal neurodegeneration in rats.
    CNS neuroscience & therapeutics, 2013, Volume: 19, Issue:8

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amyloid beta-Peptides; Animals; Hippocampus; Male; Ne

2013