fasudil has been researched along with Degenerative Diseases, Central Nervous System in 3 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fasudil is a Rho kinase inhibitor and has been reported to have neuroprotective effects." | 1.39 | Rho kinase inhibitor fasudil protects against β-amyloid-induced hippocampal neurodegeneration in rats. ( Chen, X; Gao, W; Song, Y; Wang, LY; Zhu, MJ, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 2 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Killick, R | 1 |
| Elliott, C | 1 |
| Ribe, E | 1 |
| Broadstock, M | 1 |
| Ballard, C | 1 |
| Aarsland, D | 1 |
| Williams, G | 1 |
| Lingli, C | 1 |
| Hongmei, N | 1 |
| Penghuan, J | 1 |
| Hongli, Z | 1 |
| Yuye, L | 1 |
| Rui, W | 1 |
| Fei, R | 1 |
| Zhihong, Y | 1 |
| Dongfang, H | 1 |
| Yaming, G | 1 |
| Song, Y | 1 |
| Chen, X | 1 |
| Wang, LY | 1 |
| Gao, W | 1 |
| Zhu, MJ | 1 |
1 review available for fasudil and Degenerative Diseases, Central Nervous System
| Article | Year |
|---|---|
Neurodegenerative Disease Associated Pathways in the Brains of Triple Transgenic Alzheimer's Model Mice Are Reversed Following Two Weeks of Peripheral Administration of Fasudil.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alzheimer Disease; Animals; Brain; Mice; Mice, Transg | 2023 |
2 other studies available for fasudil and Degenerative Diseases, Central Nervous System
| Article | Year |
|---|---|
Inhibition of RhoA/ROCK signalling pathway activity improves neural damage and cognitive deficits in the fluorosis model.
Topics: Animals; Cognition; Cognitive Dysfunction; Fluorides; Humans; Mice; Mice, Inbred ICR; Neurodegenerat | 2023 |
Rho kinase inhibitor fasudil protects against β-amyloid-induced hippocampal neurodegeneration in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amyloid beta-Peptides; Animals; Hippocampus; Male; Ne | 2013 |