Page last updated: 2024-10-28

fasudil and Cirrhosis, Liver

fasudil has been researched along with Cirrhosis, Liver in 7 studies

fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.

Research Excerpts

ExcerptRelevanceReference
"Fasudil has the potential to prevent liver fibrosis by activating natural killer cells and inhibiting the proliferation of hepatic stellate cells."1.62Therapeutic potentials of fasudil in liver fibrosis. ( Xi, Y; Xu, PF, 2021)
"Fasudil inhibits liver fibrosis by activating NK cells and blocking hepatic stellate cell activation, thereby providing a feasible solution for the clinical treatment of liver fibrosis."1.62Fasudil prevents liver fibrosis ( Guo, QJ; Han, QJ; Mu, YL; Su, YH; Zhang, J; Zhao, HJ; Zhao, RR, 2021)
"Ursolic acid (UA) is a traditional Chinese medicine with anti-fibrotic effects, but the molecular mechanism underlying these effects is still unclear."1.56Ursolic acid reverses liver fibrosis by inhibiting interactive NOX4/ROS and RhoA/ROCK1 signalling pathways. ( Huang, C; Liu, C; Luo, F; Luo, Q; Wan, S; Zhu, X, 2020)
"Treatment with fasudil or captopril suppressed not only the inflammation reaction but also the accumulation of the extracellular matrix due to the downregulation of TGF-β1 and MMP-9/TIMP-1, which induces the amelioration of the liver fibrosis with diabetes."1.48Fasudil alleviates hepatic fibrosis in type 1 diabetic rats: involvement of the inflammation and RhoA/ROCK pathway. ( Chu, L; Huo, M; Ma, ZH; Song, T; Wang, N; Xie, Y; Zhang, JP; Zhang, Y; Zhang, YY, 2018)
"A rat model of type 2 diabetes was established by high fat diet combined with streptozotocin (30 mg/kg, intraperitoneal injection)."1.40Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, ameliorates hepatic fibrosis in rats with type 2 diabetes. ( Deng, Y; Fang, C; Meng, F; Wang, M; Zhang, L; Zhou, H, 2014)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (57.14)24.3611
2020's3 (42.86)2.80

Authors

AuthorsStudies
Xi, Y1
Xu, PF1
Zhou, W1
Yang, Y1
Mei, C1
Dong, P1
Mu, S1
Wu, H1
Zhou, Y1
Zheng, Y1
Guo, F1
Yang, JQ1
Wan, S1
Luo, F1
Huang, C1
Liu, C1
Luo, Q1
Zhu, X1
Han, QJ1
Mu, YL1
Zhao, HJ1
Zhao, RR1
Guo, QJ1
Su, YH1
Zhang, J1
Xie, Y1
Song, T1
Huo, M1
Zhang, Y1
Zhang, YY1
Ma, ZH1
Wang, N1
Zhang, JP1
Chu, L1
Fukuda, T1
Narahara, Y1
Kanazawa, H1
Matsushita, Y1
Kidokoro, H1
Itokawa, N1
Kondo, C1
Atsukawa, M1
Nakatsuka, K1
Sakamoto, C1
Zhou, H1
Fang, C1
Zhang, L1
Deng, Y1
Wang, M1
Meng, F1

Other Studies

7 other studies available for fasudil and Cirrhosis, Liver

ArticleYear
Therapeutic potentials of fasudil in liver fibrosis.
    World journal of gastroenterology, 2021, Dec-07, Volume: 27, Issue:45

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Hepatic Stellate Cells; Humans; Killer Cells, Natural

2021
Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by
    Cells, 2019, 10-16, Volume: 8, Issue:10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Differentiation; Collagen Type I; Femal

2019
Ursolic acid reverses liver fibrosis by inhibiting interactive NOX4/ROS and RhoA/ROCK1 signalling pathways.
    Aging, 2020, 06-03, Volume: 12, Issue:11

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Animals; Carbon Tetrachloride; Disease

2020
Fasudil prevents liver fibrosis
    World journal of gastroenterology, 2021, Jun-28, Volume: 27, Issue:24

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Hepatic Stellate Cells; Killer Cells, Natura

2021
Fasudil alleviates hepatic fibrosis in type 1 diabetic rats: involvement of the inflammation and RhoA/ROCK pathway.
    European review for medical and pharmacological sciences, 2018, Volume: 22, Issue:17

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Diabetes Mellitus, Experimental; Diabetes Me

2018
Effects of fasudil on the portal and systemic hemodynamics of patients with cirrhosis.
    Journal of gastroenterology and hepatology, 2014, Volume: 29, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Animals; Arterial Pressure; Female; Hear

2014
Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, ameliorates hepatic fibrosis in rats with type 2 diabetes.
    Chinese medical journal, 2014, Volume: 127, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Connective Tissue Growth Factor; Diabetes Me

2014