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fasudil and Chronic Disease

fasudil has been researched along with Chronic Disease in 15 studies

fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.

Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).

Research Excerpts

ExcerptRelevanceReference
"To evaluate the effect of the novel intracellular calcium antagonist fasudil hydrochloride, cerebral blood flow (CBF) was measured quantitatively with positron emission tomography following the intravenous administration of fasudil in five patients with chronic cerebral infarction."9.07Effects of fasudil hydrochloride on cerebral blood flow in patients with chronic cerebral infarction. ( Hatazawa, J; Hirata, Y; Kanno, I; Kondoh, Y; Nagata, K; Satoh, Y; Shishido, F; Watahiki, Y; Yokoyama, E; Yuya, H, 1993)
"To evaluate the effect of the novel intracellular calcium antagonist fasudil hydrochloride, cerebral blood flow (CBF) was measured quantitatively with positron emission tomography following the intravenous administration of fasudil in five patients with chronic cerebral infarction."5.07Effects of fasudil hydrochloride on cerebral blood flow in patients with chronic cerebral infarction. ( Hatazawa, J; Hirata, Y; Kanno, I; Kondoh, Y; Nagata, K; Satoh, Y; Shishido, F; Watahiki, Y; Yokoyama, E; Yuya, H, 1993)
"To investigate the effect of fasudil, a Rho-kinase inhibitor, on chronic ischemia-related bladder dysfunction."3.88Protective Effect of a Rho-kinase Inhibitor on Bladder Dysfunction in a Rat Model of Chronic Bladder Ischemia. ( Aikawa, K; Akaihata, H; Haga, N; Hata, J; Ishibashi, K; Koguchi, T; Kojima, Y; Kushida, N; Matsuoka, K; Nomiya, M, 2018)
"Fasudil treatment notably ameliorated ADR-induced cardiac damage, restored heart function, suppressed cell apoptosis and senescence, ameliorated redox imbalance, and DNA damage."1.56Rho Kinase Inhibition by Fasudil Attenuates Adriamycin-Induced Chronic Heart Injury. ( Miao, D; Xiang, C; Yan, Y; Yang, Z; Zhang, D, 2020)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19901 (6.67)18.7374
1990's1 (6.67)18.2507
2000's4 (26.67)29.6817
2010's7 (46.67)24.3611
2020's2 (13.33)2.80

Authors

AuthorsStudies
Yan, Y1
Xiang, C1
Yang, Z1
Miao, D1
Zhang, D2
Detter, MR1
Shenkar, R1
Benavides, CR1
Neilson, CA1
Moore, T1
Lightle, R1
Hobson, N1
Shen, L1
Cao, Y1
Girard, R1
Griffin, E1
Gallione, CJ1
Awad, IA1
Marchuk, DA1
Chan, SL1
Cipolla, MJ1
Akaihata, H1
Nomiya, M1
Matsuoka, K1
Koguchi, T1
Hata, J1
Haga, N1
Kushida, N1
Ishibashi, K1
Aikawa, K1
Kojima, Y1
Jawad, E1
Arora, R1
Ziino, AJ1
Ivanovska, J2
Belcastro, R1
Kantores, C2
Xu, EZ2
Lau, M1
McNamara, PJ2
Tanswell, AK1
Jankov, RP2
Yoshimi, E1
Kumakura, F1
Hatori, C1
Hamachi, E1
Iwashita, A1
Ishii, N1
Terasawa, T1
Shimizu, Y1
Takeshita, N1
Engelberts, D1
Kavanagh, BP1
Blood, AB1
Terry, MH1
Merritt, TA1
Papamatheakis, DG1
Blood, Q1
Ross, JM1
Power, GG1
Longo, LD1
Wilson, SM1
Haack, KK1
Gao, L1
Schiller, AM1
Curry, PL1
Pellegrino, PR1
Zucker, IH1
Satoh, Si1
Ikegaki, I2
Toshima, Y1
Watanabe, A1
Asano, T2
Shimokawa, H2
Nagaoka, T1
Fagan, KA1
Gebb, SA1
Morris, KG1
Suzuki, T1
McMurtry, IF1
Oka, M1
Guilluy, C1
Sauzeau, V1
Rolli-Derkinderen, M1
Guérin, P1
Sagan, C1
Pacaud, P1
Loirand, G1
Nagata, K1
Kondoh, Y1
Satoh, Y1
Watahiki, Y1
Yokoyama, E1
Yuya, H1
Hirata, Y1
Shishido, F1
Hatazawa, J1
Kanno, I1
Shibuya, M1
Suzuki, Y1
Takayasu, M1
Harada, T1
Satoh, S1
Hidaka, H1

Reviews

1 review available for fasudil and Chronic Disease

ArticleYear
Chronic stable angina pectoris.
    Disease-a-month : DM, 2008, Volume: 54, Issue:9

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetanilides; Angina Pectoris; Antihypertensive Agent

2008

Trials

1 trial available for fasudil and Chronic Disease

ArticleYear
Effects of fasudil hydrochloride on cerebral blood flow in patients with chronic cerebral infarction.
    Clinical neuropharmacology, 1993, Volume: 16, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Blood Pressure; Calcium Channel Blockers; Cereb

1993

Other Studies

13 other studies available for fasudil and Chronic Disease

ArticleYear
Rho Kinase Inhibition by Fasudil Attenuates Adriamycin-Induced Chronic Heart Injury.
    Cardiovascular toxicology, 2020, Volume: 20, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Apoptosis; Biomarkers; Cardiot

2020
Novel Murine Models of Cerebral Cavernous Malformations.
    Angiogenesis, 2020, Volume: 23, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Disease; Animals; Apoptosis Regulatory Proteins

2020
Treatment with low dose fasudil for acute ischemic stroke in chronic hypertension.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017, Volume: 37, Issue:9

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cerebrovascular Circulation; Chronic Disease

2017
Protective Effect of a Rho-kinase Inhibitor on Bladder Dysfunction in a Rat Model of Chronic Bladder Ischemia.
    Urology, 2018, Volume: 111

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Chronic Disease; Disease Models, Animal; Isc

2018
Effects of rho-kinase inhibition on pulmonary hypertension, lung growth, and structure in neonatal rats chronically exposed to hypoxia.
    Pediatric research, 2010, Volume: 67, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Airway Remodeling; Amides; Animals; Animals, Newborn;

2010
Antinociceptive effects of AS1892802, a novel Rho kinase inhibitor, in rat models of inflammatory and noninflammatory arthritis.
    The Journal of pharmacology and experimental therapeutics, 2010, Sep-01, Volume: 334, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analgesics; Analgesics, Opioid; Animals; Anti-Inflamm

2010
Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension.
    American journal of physiology. Heart and circulatory physiology, 2010, Volume: 299, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Age Factors; Aging; Amides; Animals; Apoptosis; Cell

2010
Effect of chronic perinatal hypoxia on the role of rho-kinase in pulmonary artery contraction in newborn lambs.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2013, Jan-15, Volume: 304, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Altitude; Animals; Animals, Newborn; Arterial Pressur

2013
Central Rho kinase inhibition restores baroreflex sensitivity and angiotensin II type 1 receptor protein imbalance in conscious rabbits with chronic heart failure.
    Hypertension (Dallas, Tex. : 1979), 2013, Volume: 61, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Baroreflex; Brain Stem; Chronic Disease; Con

2013
Effects of Rho-kinase inhibitor on vasopressin-induced chronic myocardial damage in rats.
    Life sciences, 2002, Nov-22, Volume: 72, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cardiomyopathies; Chronic Disease; Disease M

2002
Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension.
    American journal of respiratory and critical care medicine, 2005, Mar-01, Volume: 171, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Inhalation; Administration, Oral; Ami

2005
Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension.
    British journal of pharmacology, 2005, Volume: 146, Issue:7

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Carrier Proteins; Chronic Disease; C

2005
The effects of an intracellular calcium antagonist HA 1077 on delayed cerebral vasospasm in dogs.
    Acta neurochirurgica, 1988, Volume: 90, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arteries; Calcium Channel Blockers; Cerebral

1988