fasudil has been researched along with Chemical and Drug Induced Liver Injury in 4 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fasudil is an inhibitor of Rhoa/ROCK signaling, which is involved in anti-inflammatory and anti-injury effects." | 1.62 | Fasudil alleviates acetaminophen-induced liver injury via targeting Rhoa/ROCK signal pathway. ( Li, X; Lu, L; Meng, T; Ren, X, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Namba, N | 1 |
| Kuwahara, T | 1 |
| Kondo, Y | 1 |
| Fukusaki, K | 1 |
| Miyata, K | 1 |
| Oike, Y | 1 |
| Irie, T | 1 |
| Ishitsuka, Y | 1 |
| Ren, X | 2 |
| Meng, T | 1 |
| Li, X | 1 |
| Lu, L | 1 |
| Ikeda, H | 1 |
| Kume, Y | 1 |
| Tejima, K | 1 |
| Tomiya, T | 1 |
| Nishikawa, T | 1 |
| Watanabe, N | 1 |
| Ohtomo, N | 1 |
| Arai, M | 1 |
| Arai, C | 1 |
| Omata, M | 1 |
| Fujiwara, K | 1 |
| Yatomi, Y | 1 |
4 other studies available for fasudil and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Fasudil inhibits the expression of C/EBP homologous protein to protect against liver injury in acetaminophen-overdosed mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Fasudil alleviates acetaminophen-induced liver injury via targeting Rhoa/ROCK signal pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetaminophen; Animals; Chemical and Drug Induced Liv | 2021 |
Rho-kinase inhibitor prevents hepatocyte damage in acute liver injury induced by carbon tetrachloride in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Androstadienes; Animals; Apoptosis; Carbon Tetrachlor | 2007 |