fasudil has been researched along with Cavernous Angioma, Central Nervous System in 3 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Familial cerebral cavernous malformations (CCMs) in humans result from mutations of CCM2 (malcavernin, OSM, MGC4607), PDCD10 (CCM3), or KRIT1 (CCM1), a Rap1 effector which stabilizes endothelial cell-cell junctions." | 1.36 | Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity. ( Awad, IA; Ginsberg, MH; Shenkar, R; Stockton, RA, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Detter, MR | 1 |
| Shenkar, R | 3 |
| Benavides, CR | 1 |
| Neilson, CA | 1 |
| Moore, T | 2 |
| Lightle, R | 2 |
| Hobson, N | 1 |
| Shen, L | 1 |
| Cao, Y | 2 |
| Girard, R | 2 |
| Zhang, D | 1 |
| Griffin, E | 1 |
| Gallione, CJ | 1 |
| Awad, IA | 3 |
| Marchuk, DA | 2 |
| Shi, C | 1 |
| Austin, C | 1 |
| Zhang, L | 1 |
| Wu, M | 1 |
| Zeineddine, HA | 1 |
| McDonald, DA | 1 |
| Rorrer, A | 1 |
| Gallione, C | 1 |
| Pytel, P | 1 |
| Liao, JK | 1 |
| Stockton, RA | 1 |
| Ginsberg, MH | 1 |
3 other studies available for fasudil and Cavernous Angioma, Central Nervous System
| Article | Year |
|---|---|
Novel Murine Models of Cerebral Cavernous Malformations.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Disease; Animals; Apoptosis Regulatory Proteins | 2020 |
RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Neoplasms; Disease Models, Animal; Fem | 2017 |
Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animal Structures; Animals; Brain Edema; Capillary Pe | 2010 |