fasudil has been researched along with Cardiovascular Stroke in 18 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We hypothesis that Rho kinase inhibitor fasudil ameliorates osteoporosis following myocardial infarction (MI) by regulating cardiac calcitonin secretion." | 8.12 | Fasudil Ameliorates Osteoporosis Following Myocardial Infarction by Regulating Cardiac Calcitonin Secretion. ( Xiang, C; Xu, M; Zhang, D; Zhu, Y, 2022) |
| "Myocardial infarction was produced in rats with 85 mgkg(-1) isoproterenol administered subcutaneously twice at an interval of 24 h." | 7.78 | Coptisine exert cardioprotective effect through anti-oxidative and inhibition of RhoA/Rho kinase pathway on isoproterenol-induced myocardial infarction in rats. ( Du, GH; Fang, LH; Gong, LL; Li, XX; Qin, HL; Sun, JL; Wang, SB, 2012) |
| "The current study was carried out to determine whether fasudil hydrochloride (fasudil), a Rho-kinase inhibitor, has myocardial postconditioning (PostC) activity under hyperglycemia as well as normoglycemia, and if so, whether the effects could be mediated by mitochondrial ATP-sensitive potassium (m-KATP) channels." | 7.78 | High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels. ( Cho, S; Higashijima, U; Ichinomiya, T; Maekawa, T; Matsumoto, S; Sumikawa, K, 2012) |
| "We hypothesis that Rho kinase inhibitor fasudil ameliorates osteoporosis following myocardial infarction (MI) by regulating cardiac calcitonin secretion." | 4.12 | Fasudil Ameliorates Osteoporosis Following Myocardial Infarction by Regulating Cardiac Calcitonin Secretion. ( Xiang, C; Xu, M; Zhang, D; Zhu, Y, 2022) |
| "Fasudil may induce preconditioning and postconditioning against myocardial ischemia‑reperfusion injury in normal rats, however, their effectivenesses in hypercholesterolemia remains to be determined." | 3.80 | High‑dose fasudil preconditioning and postconditioning attenuate myocardial ischemia‑reperfusion injury in hypercholesterolemic rats. ( Jia, D; Wu, N; Zhang, X, 2014) |
| "Myocardial infarction was produced in rats with 85 mgkg(-1) isoproterenol administered subcutaneously twice at an interval of 24 h." | 3.78 | Coptisine exert cardioprotective effect through anti-oxidative and inhibition of RhoA/Rho kinase pathway on isoproterenol-induced myocardial infarction in rats. ( Du, GH; Fang, LH; Gong, LL; Li, XX; Qin, HL; Sun, JL; Wang, SB, 2012) |
| "The current study was carried out to determine whether fasudil hydrochloride (fasudil), a Rho-kinase inhibitor, has myocardial postconditioning (PostC) activity under hyperglycemia as well as normoglycemia, and if so, whether the effects could be mediated by mitochondrial ATP-sensitive potassium (m-KATP) channels." | 3.78 | High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels. ( Cho, S; Higashijima, U; Ichinomiya, T; Maekawa, T; Matsumoto, S; Sumikawa, K, 2012) |
| " The present study was designed to examine the effect of fasudil, a Rho-kinase (ROCK) inhibitor, on myocardial remodeling and underlying mechanisms in pressure overload and myocardial infarction (MI) mice." | 3.78 | Inhibition of Rho-kinase ameliorates myocardial remodeling and fibrosis in pressure overload and myocardial infarction: role of TGF-β1-TAK1. ( Guo, Y; Li, Q; Li, X; Liu, G; Xu, Y, 2012) |
| " Administration of fasudil, an inhibitor of Rho-kinase, decreased myocardial infarction size from 59." | 3.75 | Inhibition of the activity of Rho-kinase reduces cardiomyocyte apoptosis in heart ischemia/reperfusion via suppressing JNK-mediated AIF translocation. ( Bian, HJ; Ji, XP; Li, XX; Liu, XB; Zhang, J; Zhang, Y, 2009) |
| "Fasudil was administered 15 min prior to ischemia, and wortmannin and L‑NAME were administered following IPoC." | 1.40 | Inhibition of Rho-kinase by fasudil restores the cardioprotection of ischemic postconditioninng in hypercholesterolemic rat heart. ( Jia, D; Li, W; Lv, Y; Shu, W; Wu, N, 2014) |
| "The total number of ventricular ectopic beats was markedly augmented with fasudil at 0." | 1.33 | Effects of fasudil, a Rho-kinase inhibitor, on myocardial preconditioning in anesthetized rats. ( Babül, A; Celik, A; Demiryürek, AT; Demiryürek, S; Kara, AF; Tarakçioglu, M, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (27.78) | 29.6817 |
| 2010's | 10 (55.56) | 24.3611 |
| 2020's | 3 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Xiang, C | 1 |
| Zhu, Y | 1 |
| Xu, M | 1 |
| Zhang, D | 1 |
| Miyahara, S | 1 |
| Jenke, A | 1 |
| Yazdanyar, M | 1 |
| Kistner, J | 1 |
| Immohr, MB | 1 |
| Sugimura, Y | 1 |
| Aubin, H | 1 |
| Kamiya, H | 1 |
| Okita, Y | 1 |
| Lichtenberg, A | 1 |
| Akhyari, P | 1 |
| Zhou, FT | 1 |
| Ma, K | 1 |
| Jiang, ZH | 1 |
| Zhang, TT | 1 |
| Zhang, JF | 1 |
| Wu, N | 3 |
| Zhang, X | 1 |
| Jia, D | 3 |
| Kitano, K | 1 |
| Usui, S | 1 |
| Ootsuji, H | 1 |
| Takashima, S | 1 |
| Kobayashi, D | 1 |
| Murai, H | 1 |
| Furusho, H | 1 |
| Nomura, A | 1 |
| Kaneko, S | 1 |
| Takamura, M | 1 |
| Li, W | 2 |
| Shu, W | 2 |
| Lv, Y | 2 |
| Cheng, YT | 1 |
| Yeih, DF | 1 |
| Liang, SM | 1 |
| Chien, CY | 1 |
| Yu, YL | 1 |
| Ko, BS | 1 |
| Jan, YJ | 1 |
| Kuo, CC | 1 |
| Sung, LY | 1 |
| Shyue, SK | 1 |
| Chen, MF | 1 |
| Yet, SF | 1 |
| Wu, KK | 1 |
| Liou, JY | 1 |
| Mera, C | 1 |
| Godoy, I | 1 |
| Ramírez, R | 1 |
| Moya, J | 1 |
| Ocaranza, MP | 1 |
| Jalil, JE | 1 |
| Zhang, J | 1 |
| Li, XX | 2 |
| Bian, HJ | 1 |
| Liu, XB | 1 |
| Ji, XP | 1 |
| Zhang, Y | 1 |
| Gong, LL | 1 |
| Fang, LH | 1 |
| Wang, SB | 2 |
| Sun, JL | 1 |
| Qin, HL | 1 |
| Du, GH | 1 |
| Ichinomiya, T | 1 |
| Cho, S | 1 |
| Higashijima, U | 1 |
| Matsumoto, S | 1 |
| Maekawa, T | 1 |
| Sumikawa, K | 1 |
| Li, Q | 1 |
| Xu, Y | 1 |
| Li, X | 1 |
| Guo, Y | 1 |
| Liu, G | 1 |
| Hattori, T | 1 |
| Shimokawa, H | 1 |
| Higashi, M | 1 |
| Hiroki, J | 1 |
| Mukai, Y | 1 |
| Tsutsui, H | 1 |
| Kaibuchi, K | 1 |
| Takeshita, A | 1 |
| Demiryürek, S | 1 |
| Kara, AF | 1 |
| Celik, A | 1 |
| Babül, A | 1 |
| Tarakçioglu, M | 1 |
| Demiryürek, AT | 1 |
| Hamid, SA | 1 |
| Bower, HS | 1 |
| Baxter, GF | 1 |
| Manintveld, OC | 1 |
| Verdouw, PD | 1 |
| Duncker, DJ | 1 |
18 other studies available for fasudil and Cardiovascular Stroke
| Article | Year |
|---|---|
Fasudil Ameliorates Osteoporosis Following Myocardial Infarction by Regulating Cardiac Calcitonin Secretion.
Topics: Animals; Calcitonin; Fibrosis; Mice; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Osteoporo | 2022 |
The combination approach with Rhokinase inhibition and mechanical circulatory support in myocardial ischemia-reperfusion injury: Rho-kinase inhibition and ventricular unloading.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Coronary Artery Disease; Humans; Male; Myoca | 2022 |
Fasudil protects against isoproterenol-induced myocardial infarction in mice via inhibiting Rho/ROCK signaling pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Dose-Response Relationship, Drug; Injections | 2020 |
Protective effects of fasudil hydrochloride post-conditioning on acute myocardial ischemia/reperfusion injury in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; bcl-2-Associated X Protein; Caspa | 2013 |
High‑dose fasudil preconditioning and postconditioning attenuate myocardial ischemia‑reperfusion injury in hypercholesterolemic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Heart; Humans; Hypercholesterolemia; KATP Ch | 2014 |
Rho-kinase activation in leukocytes plays a pivotal role in myocardial ischemia/reperfusion injury.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Cytokines; Enzyme Activation; Inf | 2014 |
Inhibition of Rho-kinase by fasudil restores the cardioprotection of ischemic postconditioninng in hypercholesterolemic rat heart.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Androstadienes; Animals; Apoptosis; Cholesterol; Coro | 2014 |
Cardioprotective effects of low-dose combination therapy with rosuvastatin and fasudil in the isolated rat heart.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Calcium Channel Blockers; Cardiot | 2014 |
Rho-associated kinase inhibitors promote the cardiac differentiation of embryonic and induced pluripotent stem cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Basic Helix-Loop-Helix Transcription | 2015 |
Mechanisms of favorable effects of Rho kinase inhibition on myocardial remodeling and systolic function after experimental myocardial infarction in the rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Disease Models, Animal; Extracellular Signal | 2016 |
Inhibition of the activity of Rho-kinase reduces cardiomyocyte apoptosis in heart ischemia/reperfusion via suppressing JNK-mediated AIF translocation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anthracenes; Apoptosis; Apoptosis Inducing F | 2009 |
Coptisine exert cardioprotective effect through anti-oxidative and inhibition of RhoA/Rho kinase pathway on isoproterenol-induced myocardial infarction in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Apoptosis; Berberine; Cardioto | 2012 |
High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Glucose; Decanoic Acids; Diazoxide; Do | 2012 |
Inhibition of Rho-kinase ameliorates myocardial remodeling and fibrosis in pressure overload and myocardial infarction: role of TGF-β1-TAK1.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Atrial Natriuretic Factor; Blotting, Western | 2012 |
Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; DNA-Binding Proteins; Drug Administration Sc | 2004 |
Effects of fasudil, a Rho-kinase inhibitor, on myocardial preconditioning in anesthetized rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Anesthesia; Animals; Blood Pressure; Carbachol; Cardi | 2005 |
Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Androstadienes; Animals; Apoptosis; Cardioton | 2007 |
The RISK of ROCK.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Apoptosis; Cardiotonic Agents; Coron | 2007 |