Page last updated: 2024-10-28

fasudil and Cardiomegaly

fasudil has been researched along with Cardiomegaly in 11 studies

fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.

Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.

Research Excerpts

ExcerptRelevanceReference
"Recent evidence indicates that the GTPase activated Rho/Rho-kinase pathway contributes angiotensin II-induced cardiac hypertrophy and vascular remodeling."7.73Inhibition of Rho-kinase by fasudil attenuated angiotensin II-induced cardiac hypertrophy in apolipoprotein E deficient mice. ( Choy, DF; da Cunha, V; Dole, WP; Halks-Miller, M; Johns, A; Li, W; Light, DR; Mahmoudi, M; Martin-McNulty, B; Schroeder, M; Vincelette, J; Wang, YX, 2005)
"In this study, the role of the RhoA/Rho-kinase (RhoA/ROCK)-signaling pathway in cardiovascular dysfunction associated with hyperthyroidism was examined with the use of fasudil, a Rho-kinase inhibitor."3.78RhoA/ROCK may involve in cardiac hypertrophy induced by experimental hyperthyroidism. ( Jianping, Z; Li, C; Na, W; Peng, G; Shengjiang, G; Yanzhong, C, 2012)
"Recent evidence indicates that the GTPase activated Rho/Rho-kinase pathway contributes angiotensin II-induced cardiac hypertrophy and vascular remodeling."3.73Inhibition of Rho-kinase by fasudil attenuated angiotensin II-induced cardiac hypertrophy in apolipoprotein E deficient mice. ( Choy, DF; da Cunha, V; Dole, WP; Halks-Miller, M; Johns, A; Li, W; Light, DR; Mahmoudi, M; Martin-McNulty, B; Schroeder, M; Vincelette, J; Wang, YX, 2005)
"The present study was undertaken to investigate the effect of fasudil, a specific Rho-kinase inhibitor, in pathological cardiac hypertrophy induced by partial abdominal aortic constriction (PAAC) for 4 weeks in comparison with physiological cardiac hypertrophy caused by chronic swimming training (CST) for 8 weeks in rats."3.73Differential role of rho-kinase in pathological and physiological cardiac hypertrophy in rats. ( Balakumar, P; Singh, M, 2006)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (36.36)29.6817
2010's7 (63.64)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zhuang, R1
Wu, J1
Lin, F1
Han, L1
Liang, X1
Meng, Q1
Jiang, Y1
Wang, Z1
Yue, A1
Gu, Y1
Fan, H1
Zhou, X1
Liu, Z1
Ocaranza, MP1
Fierro, C1
Jalil, JE1
Moya, J1
Gonzalez, L1
Molina, C1
Mancilla, C1
Yan, X1
Jiao, K1
Song, X1
Ying, Z1
Yue, P1
Xu, X1
Zhong, M1
Sun, Q1
Mikolaj, M1
Wang, A1
Brook, RD1
Chen, LC1
Rajagopalan, S1
Na, W1
Peng, G1
Jianping, Z1
Yanzhong, C1
Shengjiang, G1
Li, C1
Ho, TJ1
Huang, CC1
Huang, CY1
Lin, WT1
Satoh, S1
Kawasaki, K1
Ikegaki, I1
Asano, T1
Shimokawa, H1
Zhang, ZJ1
Fan, YF1
Zhang, ZY1
Xie, PY1
Fang, HC1
Su, YS1
Wang, YX1
da Cunha, V1
Martin-McNulty, B1
Vincelette, J1
Li, W1
Choy, DF1
Halks-Miller, M1
Mahmoudi, M1
Schroeder, M1
Johns, A1
Light, DR1
Dole, WP1
Balakumar, P1
Singh, M1
McKinsey, TA1
Kass, DA1

Reviews

1 review available for fasudil and Cardiomegaly

ArticleYear
Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface.
    Nature reviews. Drug discovery, 2007, Volume: 6, Issue:8

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cardiomegaly; Cardiovascular Agents;

2007

Other Studies

10 other studies available for fasudil and Cardiomegaly

ArticleYear
Fasudil preserves lung endothelial function and reduces pulmonary vascular remodeling in a rat model of end‑stage pulmonary hypertension with left heart disease.
    International journal of molecular medicine, 2018, Volume: 42, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cardiomegaly; Cell Line; Heart Diseases; Hum

2018
Rho kinase activation in circulating leukocytes is related to hypertensive myocardial remodeling.
    Clinical science (London, England : 1979), 2018, 08-31, Volume: 132, Issue:16

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Atrial Remodeling; Blood Pressure; Cardiomeg

2018
Shen'ge powder decreases the cardiomyocyte hypertrophy in chronic heart failure by activating the Rho protein/Rho-associated coiledcoil forming protein kinase signaling pathway.
    Journal of cellular biochemistry, 2019, Volume: 120, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Cardiomegaly; Cell Survival; Dise

2019
Air pollution and cardiac remodeling: a role for RhoA/Rho-kinase.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 296, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Atmosphere Exposure Chambers

2009
RhoA/ROCK may involve in cardiac hypertrophy induced by experimental hyperthyroidism.
    Toxicology and industrial health, 2012, Volume: 28, Issue:9

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; bcl-2-Associated X Protein; Cardi

2012
Fasudil, a Rho-kinase inhibitor, protects against excessive endurance exercise training-induced cardiac hypertrophy, apoptosis and fibrosis in rats.
    European journal of applied physiology, 2012, Volume: 112, Issue:8

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Bi

2012
Evidence of a direct cellular protective effect of Rho-kinase inhibitors on endothelin-induced cardiac myocyte hypertrophy.
    Biochemical and biophysical research communications, 2012, Jul-27, Volume: 424, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cardiomegaly; Cells, Cultured; Cytoprotectio

2012
[Effects of rho-kinase inhibitor on cardiac hypertrophy of left ventricle in spontaneously hypertensive rats].
    Zhonghua yi xue za zhi, 2012, Dec-25, Volume: 92, Issue:48

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cardiomegaly; Heart Ventricles; Male; Nifedi

2012
Inhibition of Rho-kinase by fasudil attenuated angiotensin II-induced cardiac hypertrophy in apolipoprotein E deficient mice.
    European journal of pharmacology, 2005, Apr-11, Volume: 512, Issue:2-3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Apolipoproteins E; Atrial Na

2005
Differential role of rho-kinase in pathological and physiological cardiac hypertrophy in rats.
    Pharmacology, 2006, Volume: 78, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adaptation, Physiological; Animals; Blood Pressure; C

2006