fasudil has been researched along with Carcinoma, Hepatocellular in 6 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fasudil plays an important role in interfering BTBD7-ROCK2 signaling pathway and suppressing the invasion and metastasis of hepatocellular carcinoma." | 7.80 | [Suppression of hepatocellular carcinoma invasion and metastasis by Rho-kinase inhibitor Fasudil through inhibition of BTBD7-ROCK2 signaling pathway]. ( Hu, K; Tao, Y; Wang, Z, 2014) |
| " We demonstrated that Rho kinase-associated coil-containing protein kinase (ROCK) is expressed in hepatic tissues in hepatocellular carcinoma (HCC) and confirmed its roles in cell survival in HCC cells using the ROCK inhibitor, fasudil." | 7.78 | The Rho kinase inhibitor fasudil is involved in p53-mediated apoptosis in human hepatocellular carcinoma cells. ( Asakura, T; Koizumi, S; Kumai, T; Matsumoto, N; Ohta, Y; Otsubo, T; Takagi, M; Takeba, Y; Takenoshita-Nakaya, S; Watanabe, M, 2012) |
| "Fasudil was loaded by ammonium sulfate-induced transmembrane electrochemical gradient and miR195 was condensed through electrostatic interaction." | 5.43 | Aptamer-functionalized peptide H3CR5C as a novel nanovehicle for codelivery of fasudil and miRNA-195 targeting hepatocellular carcinoma. ( Gao, Y; Gu, S; Li, X; Liu, G; Liu, Y; Wu, X; Zhang, D; Zhang, J; Zhu, G, 2016) |
| "Fasudil plays an important role in interfering BTBD7-ROCK2 signaling pathway and suppressing the invasion and metastasis of hepatocellular carcinoma." | 3.80 | [Suppression of hepatocellular carcinoma invasion and metastasis by Rho-kinase inhibitor Fasudil through inhibition of BTBD7-ROCK2 signaling pathway]. ( Hu, K; Tao, Y; Wang, Z, 2014) |
| " We demonstrated that Rho kinase-associated coil-containing protein kinase (ROCK) is expressed in hepatic tissues in hepatocellular carcinoma (HCC) and confirmed its roles in cell survival in HCC cells using the ROCK inhibitor, fasudil." | 3.78 | The Rho kinase inhibitor fasudil is involved in p53-mediated apoptosis in human hepatocellular carcinoma cells. ( Asakura, T; Koizumi, S; Kumai, T; Matsumoto, N; Ohta, Y; Otsubo, T; Takagi, M; Takeba, Y; Takenoshita-Nakaya, S; Watanabe, M, 2012) |
| "Fasudil was loaded by ammonium sulfate-induced transmembrane electrochemical gradient and miR195 was condensed through electrostatic interaction." | 1.43 | Aptamer-functionalized peptide H3CR5C as a novel nanovehicle for codelivery of fasudil and miRNA-195 targeting hepatocellular carcinoma. ( Gao, Y; Gu, S; Li, X; Liu, G; Liu, Y; Wu, X; Zhang, D; Zhang, J; Zhu, G, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, Y | 1 |
| Zhang, Y | 1 |
| Vazirinejad Mehdiabad, M | 1 |
| Zhou, K | 1 |
| Chen, Y | 2 |
| Li, L | 2 |
| Guo, J | 2 |
| Xu, C | 2 |
| Wu, H | 1 |
| Li, B | 1 |
| Li, C | 1 |
| You, J | 1 |
| Hu, X | 1 |
| Kuang, D | 1 |
| Qi, S | 1 |
| Liu, P | 1 |
| Hu, K | 1 |
| Wang, Z | 1 |
| Tao, Y | 1 |
| Liu, Y | 1 |
| Wu, X | 1 |
| Gao, Y | 1 |
| Zhang, J | 1 |
| Zhang, D | 1 |
| Gu, S | 1 |
| Zhu, G | 1 |
| Liu, G | 1 |
| Li, X | 1 |
| Grise, F | 1 |
| Bidaud, A | 1 |
| Moreau, V | 1 |
| Takeba, Y | 1 |
| Matsumoto, N | 1 |
| Watanabe, M | 1 |
| Takenoshita-Nakaya, S | 1 |
| Ohta, Y | 1 |
| Kumai, T | 1 |
| Takagi, M | 1 |
| Koizumi, S | 1 |
| Asakura, T | 1 |
| Otsubo, T | 1 |
1 review available for fasudil and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Rho GTPases in hepatocellular carcinoma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Carcinoma, Hepatocellular; Disease P | 2009 |
5 other studies available for fasudil and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Enhanced anti-tumor effect of liposomal Fasudil on hepatocellular carcinoma in vitro and in vivo.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antineoplastic Agents; Apoptosis; Apoptosis | 2019 |
Targeting ROCK1/2 blocks cell division and induces mitotic catastrophe in hepatocellular carcinoma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell D | 2021 |
[Suppression of hepatocellular carcinoma invasion and metastasis by Rho-kinase inhibitor Fasudil through inhibition of BTBD7-ROCK2 signaling pathway].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adaptor Proteins, Signal Transducing; Carcinoma, Hepa | 2014 |
Aptamer-functionalized peptide H3CR5C as a novel nanovehicle for codelivery of fasudil and miRNA-195 targeting hepatocellular carcinoma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Ammonium Sulfate; Angiogenesis Inhibitors; Animals; A | 2016 |
The Rho kinase inhibitor fasudil is involved in p53-mediated apoptosis in human hepatocellular carcinoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumo | 2012 |